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    ihfB integration host factor subunit beta [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945533, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ihfB
    Official Full Name
    integration host factor subunit beta
    Primary source
    ECOCYC:EG10441
    Locus tag
    b0912
    See related
    ASAP:ABE-0003107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0903; himD; hip
    Summary
    [More information is available at EcoCyc: EG10441].
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    Genomic context

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    Sequence:
    NC_000913.3 (963828..964112)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytidylate kinase Neighboring gene 30S ribosomal subunit protein S1 Neighboring gene metallo-beta-lactamase superfamily inner membrane protein YcaI Neighboring gene ATP-binding lipopolysaccharide transport protein Neighboring gene tetraacyldisaccharide 4'-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Escherichia coli mutant unable to support site-specific recombination of bacteriophage lambda. Kikuchi A, et al. J Mol Biol, 1985 May 25. PMID 3159904
    2. Genes coding for integration host factor are conserved in gram-negative bacteria. Haluzi H, et al. J Bacteriol, 1991 Oct. PMID 1917861, Free PMC Article
    3. Expression of the genes coding for the Escherichia coli integration host factor are controlled by growth phase, rpoS, ppGpp and by autoregulation. Aviv M, et al. Mol Microbiol, 1994 Dec. PMID 7715442
    4. Integration host factor (IHF) binds to many sites in the A + T-rich b2 region of phage lambda DNA. Kur J, et al. Gene, 1992 Feb 1. PMID 1532160
    5. Bacteriophage lambda gpNu1 and Escherichia coli IHF proteins cooperatively bind and bend viral DNA: implications for the assembly of a genome-packaging motor. Ortega ME, et al. Biochemistry, 2006 Apr 25. PMID 16618107

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cas1-Cas2-mediated spacer integration requires IHF-induced target DNA bending and explain the elusive role of CRISPR leader sequences during spacer acquisition and immunologic memory.
      Title: CRISPR Immunological Memory Requires a Host Factor for Specificity.
    2. Data show that environment dependent selection between integration host factors (IHF) and DNA-binding proteins from starved cells (Dps) results in different physical organizations of DNA.
      Title: Regulation of Bacterial DNA Packaging in Early Stationary Phase by Competitive DNA Binding of Dps and IHF.
    3. These results indicate that by combined transcriptional and translational controls of gene expression, Integration host factor activates expression of a specific set of genes required for survival at extremely acidic pH.
      Title: Integration host factor is required for the induction of acid resistance in Escherichia coli.
    4. By performing ChIP-seq experiments of each subunit of IHF in the absence of the other subunit, genome-wide maps of DNA binding of the proteins in their hetero- and homodimeric forms were defined.
      Title: Genomic analysis of DNA binding and gene regulation by homologous nucleoid-associated proteins IHF and HU in Escherichia coli K12.
    5. Activity of TraI was enhanced by the relaxosome components TraM and integration host factor. The magnitude of stimulation depended on the proximity of the specific protein binding sites to the position of open DNA.
      Title: Protein and DNA effectors control the TraI conjugative helicase of plasmid R1.
    6. In the absence of TrwA, binding of integration host factor (IHF) to the oriT keeps the recombination levels low
      Title: TrwC-mediated site-specific recombination is controlled by host factors altering local DNA topology.
    7. N-terminus verified by Edman degradation on complete protein
      Title: Small genes/gene-products in Escherichia coli K-12.
    8. analysis of the role of DNA deformation energy in sequence-specific DNA binding by Escherichia coli integration host factor
      Title: Indirect recognition in sequence-specific DNA binding by Escherichia coli integration host factor: the role of DNA deformation energy.
    9. inactivation of IHF in vivo abolishes the sigma (S)-dependent transcription initiation of the pst operon, indicating that both -13C residue and IHF are required to confer on pst the ability to be transcribed by Esigma D
      Title: The effect of IHF on sigmaS selectivity of the phoA and pst promoters of Escherichia coli.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IHF-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integration host factor subunit beta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      963828..964112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415432.1 integration host factor subunit beta [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415432.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FZ77
      Conserved Domains (1) summary
      PRK00199
      Location:1 → 94
      ihfB; integration host factor subunit beta; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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