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    gadC L-glutamate:4-aminobutyrate antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946057, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gadC
    Official Full Name
    L-glutamate:4-aminobutyrate antiporter
    Primary source
    ECOCYC:G6786
    Locus tag
    b1492
    See related
    ASAP:ABE-0004973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    acsA; ECK1486; xasA
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG12456]. GadC, a glutamic acid:-aminobutyrate antiporter, is part of the glutamate-depenent acid resistance system 2 (AR2) which confers resistance to extreme acid conditions. [More information is available at EcoCyc: G6786].
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    Genomic context

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    Sequence:
    NC_000913.3 (1568954..1570489, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YddY Neighboring gene divisome localized glycosyl hydrolase Neighboring gene glutamate decarboxylase B Neighboring gene periplasmic metalloprotease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glutamate-dependent acid resistance gene in Escherichia coli. Hersh BM, et al. J Bacteriol, 1996 Jul. PMID 8682809, Free PMC Article
    2. The glutamate-dependent acid resistance system of Escherichia coli and Shigella flexneri is inhibited in vitro by L-trans-pyrrolidine-2,4-dicarboxylic acid. Waterman SR, et al. FEMS Microbiol Lett, 2003 Jul 15. PMID 12855178
    3. Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria. Tsai MF, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530225, Free PMC Article
    4. Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes. Castanie-Cornet MP, et al. Microbiology (Reading), 2001 Mar. PMID 11238978
    5. Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coli. Lin J, et al. J Bacteriol, 1995 Jul. PMID 7608084, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular pH elevation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-glutamate:4-aminobutyrate antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1568954..1570489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416009.1 L-glutamate:4-aminobutyrate antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416009.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JYS8
      Conserved Domains (1) summary
      TIGR00910
      Location:8 → 509
      2A0307_GadC; glutamate:gamma-aminobutyrate antiporter
    Nucleotide Protein
    Heading Accession and Version

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