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    eamA cysteine/O-acetylserine exporter EamA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946081, updated on 3-Dec-2024

    Summary

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    Official Symbol
    eamA
    Official Full Name
    cysteine/O-acetylserine exporter EamA
    Primary source
    ECOCYC:EG11639
    Locus tag
    b1533
    See related
    ASAP:ABE-0005116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1526; ydeD
    Summary
    EamA belongs to the EamA/RhaT transporter family, DMT superfamily. [More information is available at EcoGene: EG11639]. YdeD is a major facilitator superfamily transporter involved in the efflux of O-acetylserine and Cysteine (metabolites of the Cysteine pathway). [More information is available at EcoCyc: EG11639].
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    Genomic context

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    Sequence:
    NC_000913.3 (1620238..1621137, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator MarA Neighboring gene multiple antibiotic resistance protein MarB Neighboring gene dipeptide exporter Neighboring gene small protein MgtS Neighboring gene protein MgtT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The L-cysteine/L-cystine shuttle system provides reducing equivalents to the periplasm in Escherichia coli. Ohtsu I, et al. J Biol Chem, 2010 Jun 4. PMID 20351115, Free PMC Article
    2. Identification of a major facilitator protein from Escherichia coli involved in efflux of metabolites of the cysteine pathway. Dassler T, et al. Mol Microbiol, 2000 Jun. PMID 10844694
    3. YfiK from Escherichia coli promotes export of O-acetylserine and cysteine. Franke I, et al. J Bacteriol, 2003 Feb. PMID 12562784, Free PMC Article
    4. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. Cohen SP, et al. J Bacteriol, 1993 Mar. PMID 8383113, Free PMC Article
    5. Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Yamada S, et al. Appl Environ Microbiol, 2006 Jul. PMID 16820466, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cysteine export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine/O-acetylserine exporter EamA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1620238..1621137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416050.4 cysteine/O-acetylserine exporter EamA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416050.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JZ21
      Conserved Domains (1) summary
      PRK11453
      Location:1 → 297
      PRK11453; O-acetylserine/cysteine exporter
    Nucleotide Protein
    Heading Accession and Version

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