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    uraA uracil:H(+) symporter UraA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946978, updated on 17-Dec-2024

    Summary

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    Official Symbol
    uraA
    Official Full Name
    uracil:H(+) symporter UraA
    Primary source
    ECOCYC:EG12129
    Locus tag
    b2497
    See related
    ASAP:ABE-0008219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2493
    Summary
    UraA is a probable high affinity uracil transporter, responsible for the uptake of uracil. [More information is available at EcoCyc: EG12129].
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    Genomic context

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    Sequence:
    NC_000913.3 (2618871..2620160, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase YfgD Neighboring gene inibitor of reinitiation of DNA replication Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin. Kalli AC, et al. PLoS Comput Biol, 2015 Mar. PMID 25729859, Free PMC Article
    2. Structure and mechanism of the uracil transporter UraA. Lu F, et al. Nature, 2011 Apr 14. PMID 21423164
    3. Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters. Yu X, et al. Cell Res, 2017 Aug. PMID 28621327, Free PMC Article
    4. Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli. Botou M, et al. Mol Microbiol, 2018 Apr. PMID 29437264
    5. Regulation of upp expression in Escherichia coli by UTP-sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription. Tu AH, et al. J Bacteriol, 1997 Nov. PMID 9352914, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UraA are permeases specific for uracil and 5-fluorouracil.
      Title: Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.
    2. Used molecular dynamics simulations to study the bacterial UraA H+-uracil symporter in lipid bilayers.
      Title: Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables nucleobase transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil:monoatomic cation symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil:monoatomic cation symporter activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uracil import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within uracil import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within uracil import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uracil transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uracil:H(+) symporter UraA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2618871..2620160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416992.1 uracil:H(+) symporter UraA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416992.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GGN1, A0A2X1NMM9
      Conserved Domains (1) summary
      PRK10720
      Location:2 → 429
      PRK10720; uracil transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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