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    holA DNA polymerase III subunit delta [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947573, updated on 3-Dec-2024

    Summary

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    Official Symbol
    holA
    Official Full Name
    DNA polymerase III subunit delta
    Primary source
    ECOCYC:EG11412
    Locus tag
    b0640
    See related
    ASAP:ABE-0002192
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0633
    Summary
    Some delta exists independent of the preinitiation complex, possibly playing a role in stripping beta clamps from DNA in the absence of replication initiation . [More information is available at EcoCyc: EG11412].
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    Genomic context

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    Sequence:
    NC_000913.3 (670574..671605, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase Neighboring gene nicotinate-nucleotide adenylyltransferase Neighboring gene lipopolysaccharide assembly protein LptE Neighboring gene leucine--tRNA ligase Neighboring gene DUF1451 domain-containing protein YbeL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme. Carter JR, et al. J Bacteriol, 1992 Nov. PMID 1400251, Free PMC Article
    2. Cost of rNTP/dNTP pool imbalance at the replication fork. Yao NY, et al. Proc Natl Acad Sci U S A, 2013 Aug 6. PMID 23882084, Free PMC Article
    3. Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly. Chen S, et al. Nucleic Acids Res, 2008 Jun. PMID 18424802, Free PMC Article
    4. A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of deltadelta' with DnaX(4) forms DnaX(3)deltadelta'. Pritchard AE, et al. EMBO J, 2000 Dec 1. PMID 11101526, Free PMC Article
    5. The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation. Song MS, et al. J Biol Chem, 2001 Sep 14. PMID 11432857

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that rNTPs decrease replication fork rate by competing with dNTPs at the active site of the C-family Pol III replicase at a step that does not require correct base-pairing.
      Title: Cost of rNTP/dNTP pool imbalance at the replication fork.
    2. Enterobacteria Gp8 inhibits the DNAP III of Escherichia coli by targeting the delta subunit of the DNAP III clamp loader.
      Title: A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader.
    3. N-terminus verified by Edman degradation on complete protein
      Title: DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of DNA polymerase III complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of DNA polymerase III, clamp loader complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of replisome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase III subunit delta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      670574..671605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415173.1 DNA polymerase III subunit delta [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415173.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3T932
      Conserved Domains (1) summary
      PRK05574
      Location:2 → 334
      holA; DNA polymerase III subunit delta; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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