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    acrE multidrug efflux pump membrane fusion lipoprotein AcrE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947706, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acrE
    Official Full Name
    multidrug efflux pump membrane fusion lipoprotein AcrE
    Primary source
    ECOCYC:EG10266
    Locus tag
    b3265
    See related
    ASAP:ABE-0010722
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3252; envC
    Summary
    AcrE is attached to the inner membrane. [More information is available at EcoGene: EG10266]. AcrEF is a multidrug efflux system in Escherichia coli that is highly homologous to the AcrAB multidrug efflux system . [More information is available at EcoCyc: EG10266].
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    Genomic context

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    Sequence:
    NC_000913.3 (3413864..3415021)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2556 domain-containing protein YhdU Neighboring gene DNA-binding transcriptional repressor EnvR Neighboring gene multidrug efflux pump RND permease AcrF Neighboring gene lipoprotein YhdV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locations of the envCD genes on the physical map of the Escherichia coli chromosome. Klein JR, et al. J Bacteriol, 1992 Jun. PMID 1592834, Free PMC Article
    2. EnvC, a new lipoprotein of the cytoplasmic membrane of Escherichia coli. Seiffer D, et al. FEMS Microbiol Lett, 1993 Mar 1. PMID 8472900
    3. Morphological mutants of Escherichia coli K12. Mapping of the env C mutation. Rodolakis A, et al. Mol Gen Genet, 1974 May 21. PMID 4600017
    4. Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure. Lu WC, et al. Proteins, 2006 Jan 1. PMID 16288462, Free PMC Article
    5. Role of multiple efflux pumps in Escherichia coli in indole expulsion. Kawamura-Sato K, et al. FEMS Microbiol Lett, 1999 Oct 15. PMID 10518736

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that the E. coli AcrEF transporter is expressed under standard laboratory conditions and plays an important role in the normal maintenance of cell division.
      Title: Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC.
    2. normal mode analyses to study important regions for drug recognition and extrusion in this transporter
      Title: Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to antibiotic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug efflux pump membrane fusion lipoprotein AcrE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3413864..3415021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417731.1 multidrug efflux pump membrane fusion lipoprotein AcrE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417731.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9X1W5
      Conserved Domains (1) summary
      PRK15030
      Location:1 → 384
      PRK15030; multidrug efflux RND transporter periplasmic adaptor subunit AcrA
    Nucleotide Protein
    Heading Accession and Version

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