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    aroE shikimate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947776, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aroE
    Official Full Name
    shikimate dehydrogenase
    Primary source
    ECOCYC:EG10077
    Locus tag
    b3281
    See related
    ASAP:ABE-0010763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3268
    Summary
    Also called dehydroshikimate reductase. [More information is available at EcoGene: EG10077].
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    Genomic context

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    Sequence:
    NC_000913.3 (3430020..3430838, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S ribosomal RNA Neighboring gene hexapeptide repeat-containing protein YrdA Neighboring gene DUF1488 domain-containing protein YrdB Neighboring gene L-threonylcarbamoyladenylate synthase Neighboring gene putative DNA topoisomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass. Singh S, et al. Mol Biol Evol, 2008 Oct. PMID 18669580
    2. The purification of shikimate dehydrogenase from Escherichia coli. Chaudhuri S, et al. Biochem J, 1985 Feb 15. PMID 3883995, Free PMC Article
    3. The shikimate pathway : II. Stereospecificity of hydrogen transfer catalyzed by NADPH-dehydroshikimate reductase of E. coli. Dansette P, et al. Biochimie, 1974. PMID 4155957
    4. Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme. Lamb HK, et al. Biochem J, 1996 Feb 1. PMID 8611179, Free PMC Article
    5. Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Escherichia coli. Schmitz M, et al. Biotechnol Prog, 2002 Sep-Oct. PMID 12363343

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables shikimate 3-dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables shikimate 3-dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables shikimate 3-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aromatic amino acid family biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorismate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chorismate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in shikimate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in shikimate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in shikimate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shikimate dehydrogenase
    NP_417740.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3430020..3430838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417740.1 shikimate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417740.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1F5D2
      Conserved Domains (1) summary
      TIGR00507
      Location:2 → 271
      aroE; shikimate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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