MTSS1 MTSS I-BAR domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MTSS1provided by HGNC
Official Full Name: MTSS I-BAR domain containing 1provided by HGNC
Primary source: HGNC:HGNC:20443
See related: Ensembl:ENSG00000170873 MIM:608486; AllianceGenome:HGNC:20443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIM; MIMA; MIMB
Summary: Enables actin monomer binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and renal tubule development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (124550784..124728473, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (125683798..125861532, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (125563025..125740714, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
Title: The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
Title: Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis.
Title: Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
Title: MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
Title: Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
Title: Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
Title: Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
Title: A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
Title: MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
Title: miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46386 (e-PCR)
- UniSTS:18189

RH18269 (e-PCR)
- UniSTS:44045

A008N08 (e-PCR)
- UniSTS:5903

SHGC-150814 (e-PCR)
- UniSTS:173329

RH129192 (e-PCR)
- UniSTS:212500

SGC30260 (e-PCR)
- UniSTS:81488

D17S825E (e-PCR)
- UniSTS:1110

G32763 (e-PCR)
- UniSTS:117344

D8S2132 (e-PCR)
- UniSTS:68204

D8S58 (e-PCR)
- UniSTS:148595

RH46986 (e-PCR)
- UniSTS:76438

STS-H91255 (e-PCR)
- UniSTS:49560

D8S1799 (e-PCR)
- UniSTS:64440

D8S1357E (e-PCR)
- UniSTS:69325

A009Q06 (e-PCR)
- UniSTS:83405

WI-21130 (e-PCR)
- UniSTS:50645

RH69480 (e-PCR)
- UniSTS:32982

RH80990 (e-PCR)
- UniSTS:83680

RH68595 (e-PCR)
- UniSTS:65278

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in adherens junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to fluid shear stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell proliferation involved in renal tubule morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerulus morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in microspike assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal tubule morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	TAS Traceable Author Statement more info	PubMed
located_in ruffle	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein MTSS 1

Names: MTSS1, I-BAR domain containing; metastasis suppressor 1; metastasis suppressor YGL-1; metastasis suppressor protein 1; missing in metastasis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282971.2 → NP_001269900.1 protein MTSS 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC090198, AJ710067, AK027015, DA790325

Consensus CDS

CCDS64969.1

UniProtKB/TrEMBL

A5YM41

Related

ENSP00000322804.5, ENST00000325064.9

Conserved Domains (3) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:330 → 729

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:728 → 758

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
NM_001282974.2 → NP_001269903.1 protein MTSS 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AC090198, AF086645, AJ710067, DA790325, EF560715

Consensus CDS

CCDS64968.1

UniProtKB/TrEMBL

A5YM41

Related

ENSP00000367256.3, ENST00000378017.7

Conserved Domains (3) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:400 → 700

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:699 → 729

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
NM_001363294.2 → NP_001350223.1 protein MTSS 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC090198, AF086645, AJ710067, CN348724, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (3) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam02205
Location:723 → 749

WH2; WH2 motif

cl26464
Location:325 → 724

Atrophin-1; Atrophin-1 family
NM_001363295.2 → NP_001350224.1 protein MTSS 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC090198, AF086645, AJ710067, DA447614, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (3) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:326 → 708

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:707 → 737

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
NM_001363296.2 → NP_001350225.1 protein MTSS 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (3) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:404 → 704

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:703 → 733

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
NM_001363297.2 → NP_001350226.1 protein MTSS 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (4) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:567 → 695

Gag_spuma; Spumavirus gag protein

pfam02205
Location:702 → 728

WH2; WH2 motif

cl26464
Location:403 → 703

Atrophin-1; Atrophin-1 family
NM_001363298.2 → NP_001350227.1 protein MTSS 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BY993850, DA225605, DA227466, DA785323, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (4) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:563 → 691

Gag_spuma; Spumavirus gag protein

pfam02205
Location:698 → 724

WH2; WH2 motif

cl26464
Location:399 → 699

Atrophin-1; Atrophin-1 family
NM_001363299.2 → NP_001350228.1 protein MTSS 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cl26464
Location:338 → 664

Atrophin-1; Atrophin-1 family
NM_001363300.2 → NP_001350229.1 protein MTSS 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cl26464
Location:334 → 660

Atrophin-1; Atrophin-1 family
NM_001363301.2 → NP_001350230.1 protein MTSS 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502

UniProtKB/TrEMBL

A5YM41

Conserved Domains (3) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam02205
Location:658 → 684

WH2; WH2 motif

cl26464
Location:333 → 659

Atrophin-1; Atrophin-1 family
NM_001363302.2 → NP_001350231.1 protein MTSS 1 isoform 12

Status: VALIDATED

Source sequence(s)

AC090198, AF086645, AJ710067, DA790325

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cl26464
Location:326 → 644

Atrophin-1; Atrophin-1 family
NM_014751.6 → NP_055566.3 protein MTSS 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC090198, AF086645, AJ710067, DA790325

Consensus CDS

CCDS6353.1

UniProtKB/Swiss-Prot

J3KNK6, O43312, Q8TCA2, Q96RX2

UniProtKB/TrEMBL

A5YM41

Related

ENSP00000429064.1, ENST00000518547.6

Conserved Domains (3) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:326 → 725

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:724 → 754

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

124550784..124728473 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422493.1 → XP_047278449.1 protein MTSS 1 isoform X22
XM_047422490.1 → XP_047278446.1 protein MTSS 1 isoform X18
XM_017014086.3 → XP_016869575.1 protein MTSS 1 isoform X4

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:697 → 825

Gag_spuma; Spumavirus gag protein
XM_017014089.3 → XP_016869578.1 protein MTSS 1 isoform X8

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:672 → 800

Gag_spuma; Spumavirus gag protein
XM_017014092.3 → XP_016869581.1 protein MTSS 1 isoform X13

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:633 → 761

Gag_spuma; Spumavirus gag protein
XM_006716701.3 → XP_006716764.1 protein MTSS 1 isoform X3

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:698 → 826

Gag_spuma; Spumavirus gag protein
XM_017014088.3 → XP_016869577.1 protein MTSS 1 isoform X7

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 237

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:673 → 801

Gag_spuma; Spumavirus gag protein
XM_047422492.1 → XP_047278448.1 protein MTSS 1 isoform X20
XM_006716704.3 → XP_006716767.1 protein MTSS 1 isoform X16

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:329 → 728

PHA03247; large tegument protein UL36; Provisional
XM_006716700.3 → XP_006716763.1 protein MTSS 1 isoform X2

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:701 → 829

Gag_spuma; Spumavirus gag protein
XM_006716706.3 → XP_006716769.1 protein MTSS 1 isoform X21

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:341 → 647

PHA03247; large tegument protein UL36; Provisional
XM_006716703.3 → XP_006716766.1 protein MTSS 1 isoform X15

Conserved Domains (3) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:330 → 756

PHA03247; large tegument protein UL36; Provisional

pfam03276
Location:620 → 748

Gag_spuma; Spumavirus gag protein
XM_005251113.3 → XP_005251170.1 protein MTSS 1 isoform X11

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:637 → 765

Gag_spuma; Spumavirus gag protein
XM_006716705.3 → XP_006716768.1 protein MTSS 1 isoform X17

UniProtKB/TrEMBL

A5YM41

Conserved Domains (3) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

PHA03247
Location:330 → 712

PHA03247; large tegument protein UL36; Provisional

cd22060
Location:711 → 741

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
XM_006716702.3 → XP_006716765.1 protein MTSS 1 isoform X5

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:685 → 813

Gag_spuma; Spumavirus gag protein
XM_005251111.3 → XP_005251168.1 protein MTSS 1 isoform X1

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:702 → 830

Gag_spuma; Spumavirus gag protein
XM_017014087.3 → XP_016869576.1 protein MTSS 1 isoform X6

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

cd07643
Location:7 → 241

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

pfam03276
Location:677 → 805

Gag_spuma; Spumavirus gag protein
XM_011517403.2 → XP_011515705.1 protein MTSS 1 isoform X12

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

pfam03276
Location:635 → 763

Gag_spuma; Spumavirus gag protein

cl12013
Location:1 → 174

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017014091.2 → XP_016869580.1 protein MTSS 1 isoform X10

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

pfam03276
Location:639 → 767

Gag_spuma; Spumavirus gag protein

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047422491.1 → XP_047278447.1 protein MTSS 1 isoform X19

Related

ENSP00000428319.1, ENST00000524090.5
XM_017014090.3 → XP_016869579.1 protein MTSS 1 isoform X9

UniProtKB/TrEMBL

A5YM41

Conserved Domains (2) summary

pfam03276
Location:647 → 775

Gag_spuma; Spumavirus gag protein

cl12013
Location:15 → 186

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047422488.1 → XP_047278444.1 protein MTSS 1 isoform X14