Literature
PubMed
PubMed® comprises more than 38 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Featured Bookshelf titles
Browse the Bookshelf
Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
Study Reveals a Cell-Eat-Cell World
From normal vertebrate development to tumor cell cannibalism, cell-in-cell events occur in many different contexts across the tree of life
Researchers Bioengin-Ear Tissue Scaffolds to Human Scale
A new approach to sculpting human-like ears merges 3D printing, xenografts, and tissue engineering.
Do cats experience grief? New research suggests they might
Researchers from Oakland University surveyed hundreds of cat caregivers and found that cats exhibited behaviors associated with grief after a fellow cat or dog in the household died.
Recent blog posts
A Cross-Continent Commitment: NLM and the Africa CDC are Advancing Global Genomic Data
NLM recently brought together 25 researchers from across Africa to the Africa Centres for Disease Control and Prevention, for a hands-on workshop focused on curating high-quality genomic data for submission to repositories, enhancing research collaboration, and supporting public health efforts.
Explore 3D Molecular Structures with iCn3D
Do you want to analyze three-dimensional structures and highlight important features like active site residues, point mutations, and binding partners? Check out NCBI’s “I see in 3D” (iCn3D) – a free, web-based tool that allows you to explore the structure of a biomolecule at an atomistic level. Features & Benefits Interactively view 3D structure and … Continue reading Explore 3D Molecular Structures with iCn3D
Human Tumor Atlases Provide Important Insights into How Cancer Tumors Develop and Spread
In 2018, NIH’s National Cancer Institute launched a research initiative called the Human Tumor Atlas Network (HTAN) to construct detailed, three-dimensional maps of human tumors including their underlying cellular, molecular, and spatial features to better understand cancer biology. I’m pleased to share progress toward this goal through an impressive collection of HTAN studies that elucidate how tumors of various types develop, respond to treatment, and recur. Several of these studies, reported in the Nature portfolio of journals, offer key insights into the role of a tumor’s immediate surroundings and the immune system in encouraging cancer’s spread and resistance to treatment. They map the molecular and cellular features underlying the transformation of precancerous lesions into cancerous tumors and other important cancer transitions. Other studies describe innovative technologies and analytical tools that may be applied to the new findings, as well as many other datasets and studies.