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Items: 1 to 20 of 3524

1.

rs1491564683 [Homo sapiens]
    Variant type:
    DELINS
    Alleles:
    ->CAGCCCGGGGGGTG [Show Flanks]
    Chromosome:
    19:49861566 (GRCh38)
    19:50364824 (GRCh37)
    Canonical SPDI:
    NC_000019.10:49861566:GGGGGTGCAGCCCGGGGGGTG:GGGGGTGCAGCCCGGGGGGTGCAGCCCGGGGGGTG
    Gene:
    PNKP (Varview)
    Functional Consequence:
    intron_variant
    HGVS:
    2.

    rs1491474502 has merged into rs749242089 [Homo sapiens]
      Variant type:
      DELINS
      Alleles:
      TTTTTTTTTTTTTTTTT>-,TTT,TTTT,TTTTT,TTTTTT,TTTTTTT,TTTTTTTT,TTTTTTTTT,TTTTTTTTTT,TTTTTTTTTTT,TTTTTTTTTTTT,TTTTTTTTTTTTT,TTTTTTTTTTTTTT,TTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT,TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT [Show Flanks]
      Chromosome:
      19:49865609 (GRCh38)
      19:50368866 (GRCh37)
      Canonical SPDI:
      NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT,NC_000019.10:49865601:TTTTTTTTTTTTTTTTTTTTTTTT:TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
      Gene:
      PNKP (Varview)
      Functional Consequence:
      intron_variant
      Clinical significance:
      likely-benign
      Validated:
      by frequency,by alfa,by cluster
      MAF:
      TTTTTTT=0./0 (ALFA)
      -=0.125/5 (GENOME_DK)
      HGVS:
      NC_000019.10:g.49865609_49865625del, NC_000019.10:g.49865612_49865625del, NC_000019.10:g.49865613_49865625del, NC_000019.10:g.49865614_49865625del, NC_000019.10:g.49865615_49865625del, NC_000019.10:g.49865616_49865625del, NC_000019.10:g.49865617_49865625del, NC_000019.10:g.49865618_49865625del, NC_000019.10:g.49865619_49865625del, NC_000019.10:g.49865620_49865625del, NC_000019.10:g.49865621_49865625del, NC_000019.10:g.49865622_49865625del, NC_000019.10:g.49865623_49865625del, NC_000019.10:g.49865624_49865625del, NC_000019.10:g.49865625del, NC_000019.10:g.49865625dup, NC_000019.10:g.49865624_49865625dup, NC_000019.10:g.49865623_49865625dup, NC_000019.10:g.49865622_49865625dup, NC_000019.10:g.49865621_49865625dup, NC_000019.10:g.49865620_49865625dup, NC_000019.10:g.49865625_49865626insTTTTTTTTTTTTTTTTTTTTTTTTTT, NC_000019.10:g.49865625_49865626insTTTTTTTTTTTTTTTTTTTTTTTTTTTT, NC_000019.10:g.49865625_49865626insTTTTTTTTTTTTTTTTTTTTTTTTTTTTT, NC_000019.9:g.50368866_50368882del, NC_000019.9:g.50368869_50368882del, NC_000019.9:g.50368870_50368882del, NC_000019.9:g.50368871_50368882del, NC_000019.9:g.50368872_50368882del, NC_000019.9:g.50368873_50368882del, NC_000019.9:g.50368874_50368882del, NC_000019.9:g.50368875_50368882del, NC_000019.9:g.50368876_50368882del, NC_000019.9:g.50368877_50368882del, NC_000019.9:g.50368878_50368882del, NC_000019.9:g.50368879_50368882del, NC_000019.9:g.50368880_50368882del, NC_000019.9:g.50368881_50368882del, NC_000019.9:g.50368882del, NC_000019.9:g.50368882dup, NC_000019.9:g.50368881_50368882dup, NC_000019.9:g.50368880_50368882dup, NC_000019.9:g.50368879_50368882dup, NC_000019.9:g.50368878_50368882dup, NC_000019.9:g.50368877_50368882dup, NC_000019.9:g.50368882_50368883insTTTTTTTTTTTTTTTTTTTTTTTTTT, NC_000019.9:g.50368882_50368883insTTTTTTTTTTTTTTTTTTTTTTTTTTTT, NC_000019.9:g.50368882_50368883insTTTTTTTTTTTTTTTTTTTTTTTTTTTTT, NG_027717.1:g.6948_6964del, NG_027717.1:g.6951_6964del, NG_027717.1:g.6952_6964del, NG_027717.1:g.6953_6964del, NG_027717.1:g.6954_6964del, NG_027717.1:g.6955_6964del, NG_027717.1:g.6956_6964del, NG_027717.1:g.6957_6964del, NG_027717.1:g.6958_6964del, NG_027717.1:g.6959_6964del, NG_027717.1:g.6960_6964del, NG_027717.1:g.6961_6964del, NG_027717.1:g.6962_6964del, NG_027717.1:g.6963_6964del, NG_027717.1:g.6964del, NG_027717.1:g.6964dup, NG_027717.1:g.6963_6964dup, NG_027717.1:g.6962_6964dup, NG_027717.1:g.6961_6964dup, NG_027717.1:g.6960_6964dup, NG_027717.1:g.6959_6964dup, NG_027717.1:g.6964_6965insAAAAAAAAAAAAAAAAAAAAAAAAAA, NG_027717.1:g.6964_6965insAAAAAAAAAAAAAAAAAAAAAAAAAAAA, NG_027717.1:g.6964_6965insAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
      3.

      rs1491450722 [Homo sapiens]
        Variant type:
        SNV:
        Alleles:
        ->AA
        Chromosome:
        no mapping
        Canonical SPDI:
        4.

        rs1491307538 [Homo sapiens]
          Variant type:
          DELINS
          Alleles:
          ->G [Show Flanks]
          Chromosome:
          19:49860934 (GRCh38)
          19:50364192 (GRCh37)
          Canonical SPDI:
          NC_000019.10:49860934:GGGG:GGGGG
          Gene:
          PNKP (Varview), PTOV1 (Varview), PTOV1-AS2 (Varview)
          Functional Consequence:
          2KB_upstream_variant,downstream_transcript_variant,upstream_transcript_variant,500B_downstream_variant
          Validated:
          by frequency,by alfa,by cluster
          MAF:
          GGGGG=0./0 (ALFA)
          G=0.00003/8 (TOPMED)
          G=0.000036/5 (GnomAD)
          G=0.000156/1 (1000Genomes)
          HGVS:
          5.

          rs1491203401 [Homo sapiens]
            Variant type:
            DELINS
            Alleles:
            ->A [Show Flanks]
            Chromosome:
            19:49869383 (GRCh38)
            19:50372641 (GRCh37)
            Canonical SPDI:
            NC_000019.10:49869383:AAA:AAAA
            Gene:
            PNKP (Varview), AKT1S1 (Varview)
            Functional Consequence:
            2KB_upstream_variant,upstream_transcript_variant,3_prime_UTR_variant
            Validated:
            by frequency,by alfa,by cluster
            MAF:
            AAAA=0./0 (ALFA)
            A=0.000007/1 (GnomAD)
            A=0.000011/3 (TOPMED)
            HGVS:
            6.

            rs1490864164 [Homo sapiens]
              Variant type:
              SNV
              Alleles:
              C>T [Show Flanks]
              Chromosome:
              19:49861504 (GRCh38)
              19:50364761 (GRCh37)
              Canonical SPDI:
              NC_000019.10:49861503:C:T
              Gene:
              PNKP (Varview)
              Functional Consequence:
              missense_variant,coding_sequence_variant
              Validated:
              by frequency,by alfa,by cluster
              MAF:
              T=0./0 (ALFA)
              T=0.000004/1 (GnomAD_exomes)
              T=0.000004/1 (TOPMED)
              T=0.000007/1 (GnomAD)
              HGVS:
              7.

              rs1490857641 [Homo sapiens]
                Variant type:
                SNV
                Alleles:
                G>A,T [Show Flanks]
                Chromosome:
                19:49862494 (GRCh38)
                19:50365751 (GRCh37)
                Canonical SPDI:
                NC_000019.10:49862493:G:A,NC_000019.10:49862493:G:T
                Gene:
                PNKP (Varview)
                Functional Consequence:
                intron_variant
                Validated:
                by frequency,by alfa
                MAF:
                T=0./0 (ALFA)
                HGVS:
                8.

                rs1490718251 [Homo sapiens]
                  Variant type:
                  SNV
                  Alleles:
                  G>A,T [Show Flanks]
                  Chromosome:
                  19:49867906 (GRCh38)
                  19:50371163 (GRCh37)
                  Canonical SPDI:
                  NC_000019.10:49867905:G:A,NC_000019.10:49867905:G:T
                  Gene:
                  PNKP (Varview)
                  Functional Consequence:
                  2KB_upstream_variant,upstream_transcript_variant
                  Validated:
                  by frequency,by alfa,by cluster
                  MAF:
                  T=0./0 (ALFA)
                  A=0.000004/1 (TOPMED)
                  T=0.000007/1 (GnomAD)
                  HGVS:
                  9.

                  rs1490712809 [Homo sapiens]
                    Variant type:
                    SNV
                    Alleles:
                    C>A [Show Flanks]
                    Chromosome:
                    19:49868668 (GRCh38)
                    19:50371925 (GRCh37)
                    Canonical SPDI:
                    NC_000019.10:49868667:C:A
                    Gene:
                    PNKP (Varview), AKT1S1 (Varview)
                    Functional Consequence:
                    2KB_upstream_variant,downstream_transcript_variant,upstream_transcript_variant,500B_downstream_variant
                    Validated:
                    by frequency,by alfa,by cluster
                    MAF:
                    A=0./0 (ALFA)
                    A=0.000004/1 (TOPMED)
                    A=0.000007/1 (GnomAD)
                    HGVS:
                    10.

                    rs1489897200 [Homo sapiens]
                      Variant type:
                      SNV
                      Alleles:
                      A>G [Show Flanks]
                      Chromosome:
                      19:49869120 (GRCh38)
                      19:50372377 (GRCh37)
                      Canonical SPDI:
                      NC_000019.10:49869119:A:G
                      Gene:
                      PNKP (Varview), AKT1S1 (Varview)
                      Functional Consequence:
                      2KB_upstream_variant,upstream_transcript_variant,3_prime_UTR_variant
                      Validated:
                      by frequency,by alfa
                      MAF:
                      G=0./0 (ALFA)
                      G=0.000004/1 (TOPMED)
                      HGVS:
                      11.

                      rs1489804605 [Homo sapiens]
                        Variant type:
                        SNV
                        Alleles:
                        G>A,T [Show Flanks]
                        Chromosome:
                        19:49862984 (GRCh38)
                        19:50366241 (GRCh37)
                        Canonical SPDI:
                        NC_000019.10:49862983:G:A,NC_000019.10:49862983:G:T
                        Gene:
                        PNKP (Varview)
                        Functional Consequence:
                        intron_variant
                        Validated:
                        by frequency,by alfa,by cluster
                        MAF:
                        T=0./0 (ALFA)
                        A=0.00006/1 (TOMMO)
                        HGVS:
                        12.

                        rs1489414430 [Homo sapiens]
                          Variant type:
                          SNV
                          Alleles:
                          G>C,T [Show Flanks]
                          Chromosome:
                          19:49866307 (GRCh38)
                          19:50369564 (GRCh37)
                          Canonical SPDI:
                          NC_000019.10:49866306:G:C,NC_000019.10:49866306:G:T
                          Gene:
                          PNKP (Varview)
                          Functional Consequence:
                          intron_variant
                          Validated:
                          by frequency,by alfa,by cluster
                          MAF:
                          T=0./0 (ALFA)
                          T=0.000007/1 (GnomAD)
                          HGVS:
                          13.

                          rs1488738147 [Homo sapiens]
                            Variant type:
                            SNV
                            Alleles:
                            G>A [Show Flanks]
                            Chromosome:
                            19:49869126 (GRCh38)
                            19:50372383 (GRCh37)
                            Canonical SPDI:
                            NC_000019.10:49869125:G:A
                            Gene:
                            PNKP (Varview), AKT1S1 (Varview)
                            Functional Consequence:
                            2KB_upstream_variant,upstream_transcript_variant,3_prime_UTR_variant
                            Validated:
                            by frequency,by alfa
                            MAF:
                            A=0./0 (ALFA)
                            A=0.000008/2 (TOPMED)
                            HGVS:
                            14.

                            rs1488715255 [Homo sapiens]
                              Variant type:
                              SNV
                              Alleles:
                              C>T [Show Flanks]
                              Chromosome:
                              19:49869376 (GRCh38)
                              19:50372633 (GRCh37)
                              Canonical SPDI:
                              NC_000019.10:49869375:C:T
                              Gene:
                              PNKP (Varview), AKT1S1 (Varview)
                              Functional Consequence:
                              2KB_upstream_variant,upstream_transcript_variant,3_prime_UTR_variant
                              Validated:
                              by frequency,by alfa,by cluster
                              MAF:
                              T=0.000285/4 (ALFA)
                              T=0.000029/4 (GnomAD)
                              T=0.000045/12 (TOPMED)
                              HGVS:
                              15.

                              rs1488660891 [Homo sapiens]
                                Variant type:
                                SNV
                                Alleles:
                                C>T [Show Flanks]
                                Chromosome:
                                19:49861831 (GRCh38)
                                19:50365088 (GRCh37)
                                Canonical SPDI:
                                NC_000019.10:49861830:C:T
                                Gene:
                                PNKP (Varview)
                                Functional Consequence:
                                synonymous_variant,coding_sequence_variant
                                Clinical significance:
                                likely-benign
                                Validated:
                                by frequency,by alfa,by cluster
                                MAF:
                                T=0./0 (ALFA)
                                T=0.000004/1 (TOPMED)
                                T=0.000005/1 (GnomAD_exomes)
                                T=0.000007/1 (GnomAD)
                                HGVS:
                                16.

                                rs1488577824 [Homo sapiens]
                                  Variant type:
                                  SNV
                                  Alleles:
                                  C>T [Show Flanks]
                                  Chromosome:
                                  19:49861337 (GRCh38)
                                  19:50364594 (GRCh37)
                                  Canonical SPDI:
                                  NC_000019.10:49861336:C:T
                                  Gene:
                                  PNKP (Varview)
                                  Functional Consequence:
                                  missense_variant,coding_sequence_variant
                                  Clinical significance:
                                  uncertain-significance
                                  Validated:
                                  by frequency,by alfa,by cluster
                                  MAF:
                                  T=0./0 (ALFA)
                                  T=0.000014/2 (GnomAD)
                                  T=0.000015/4 (TOPMED)
                                  HGVS:
                                  17.

                                  rs1488381495 [Homo sapiens]
                                    Variant type:
                                    SNV
                                    Alleles:
                                    C>A,T [Show Flanks]
                                    Chromosome:
                                    19:49868552 (GRCh38)
                                    19:50371809 (GRCh37)
                                    Canonical SPDI:
                                    NC_000019.10:49868551:C:A,NC_000019.10:49868551:C:T
                                    Gene:
                                    PNKP (Varview), AKT1S1 (Varview)
                                    Functional Consequence:
                                    2KB_upstream_variant,downstream_transcript_variant,upstream_transcript_variant,500B_downstream_variant
                                    Validated:
                                    by frequency,by alfa,by cluster
                                    MAF:
                                    A=0./0 (ALFA)
                                    A=0.000004/1 (TOPMED)
                                    A=0.000014/2 (GnomAD)
                                    T=0.000035/1 (TOMMO)
                                    HGVS:
                                    18.

                                    rs1488369728 [Homo sapiens]
                                      Variant type:
                                      SNV
                                      Alleles:
                                      G>A [Show Flanks]
                                      Chromosome:
                                      19:49869440 (GRCh38)
                                      19:50372697 (GRCh37)
                                      Canonical SPDI:
                                      NC_000019.10:49869439:G:A
                                      Gene:
                                      PNKP (Varview), AKT1S1 (Varview)
                                      Functional Consequence:
                                      2KB_upstream_variant,upstream_transcript_variant,3_prime_UTR_variant
                                      Validated:
                                      by frequency,by alfa,by cluster
                                      MAF:
                                      A=0./0 (ALFA)
                                      A=0.000004/1 (TOPMED)
                                      A=0.000007/1 (GnomAD)
                                      HGVS:
                                      19.

                                      rs1488274497 [Homo sapiens]
                                        Variant type:
                                        SNV
                                        Alleles:
                                        T>C,G [Show Flanks]
                                        Chromosome:
                                        19:49865638 (GRCh38)
                                        19:50368895 (GRCh37)
                                        Canonical SPDI:
                                        NC_000019.10:49865637:T:C,NC_000019.10:49865637:T:G
                                        Gene:
                                        PNKP (Varview)
                                        Functional Consequence:
                                        intron_variant
                                        Validated:
                                        by frequency,by alfa,by cluster
                                        MAF:
                                        C=0.000071/1 (ALFA)
                                        C=0.000008/1 (GnomAD)
                                        HGVS:
                                        20.

                                        rs1488138163 [Homo sapiens]
                                          Variant type:
                                          SNV
                                          Alleles:
                                          C>T [Show Flanks]
                                          Chromosome:
                                          19:49861539 (GRCh38)
                                          19:50364796 (GRCh37)
                                          Canonical SPDI:
                                          NC_000019.10:49861538:C:T
                                          Gene:
                                          PNKP (Varview)
                                          Functional Consequence:
                                          intron_variant
                                          Validated:
                                          by frequency
                                          MAF:
                                          T=0.000004/1 (GnomAD_exomes)
                                          HGVS:

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