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Items: 1 to 20 of 343

1.

rs1484397011 [Homo sapiens]
    Variant type:
    SNV
    Alleles:
    T>C [Show Flanks]
    Chromosome:
    6:154091237 (GRCh38)
    6:154412372 (GRCh37)
    Canonical SPDI:
    NC_000006.12:154091236:T:C
    Gene:
    OPRM1 (Varview)
    Functional Consequence:
    coding_sequence_variant,missense_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,intron_variant
    Validated:
    by frequency
    MAF:
    C=0.000004/1 (GnomAD_exomes)
    HGVS:
    NC_000006.12:g.154091237T>C, NC_000006.11:g.154412372T>C, NG_021208.2:g.85737T>C, NM_000914.5:c.929T>C, NM_000914.4:c.929T>C, NM_000914.3:c.929T>C, NM_001145279.4:c.1208T>C, NM_001145279.3:c.1208T>C, NM_001145279.2:c.1208T>C, NM_001145280.4:c.629T>C, NM_001145280.3:c.629T>C, NM_001145280.2:c.629T>C, NM_001008504.4:c.929T>C, NM_001008504.3:c.929T>C, NM_001008504.2:c.929T>C, NM_001145287.3:c.629T>C, NM_001145287.2:c.629T>C, NM_001145287.1:c.629T>C, NM_001145281.3:c.686T>C, NM_001145281.2:c.686T>C, NM_001145281.1:c.686T>C, NM_001145284.3:c.929T>C, NM_001145284.2:c.929T>C, NM_001145286.3:c.929T>C, NM_001145286.2:c.929T>C, NM_001145286.1:c.929T>C, NM_001008503.3:c.929T>C, NM_001008503.2:c.929T>C, NM_001008503.1:c.929T>C, NM_001285523.3:c.929T>C, NM_001285523.2:c.929T>C, NM_001285523.1:c.929T>C, NM_001145285.3:c.929T>C, NM_001145285.2:c.929T>C, NM_001145285.1:c.929T>C, NM_001285526.2:c.629T>C, NM_001285526.1:c.629T>C, NM_001145283.2:c.929T>C, NM_001145283.1:c.929T>C, NM_001008505.2:c.929T>C, NM_001008505.1:c.929T>C, NM_001145282.2:c.929T>C, NM_001145282.1:c.929T>C, NM_001285528.2:c.629T>C, NM_001285528.1:c.629T>C, NM_001285524.1:c.1208T>C, NR_104348.1:n.1063T>C, NR_104350.1:n.710T>C, NR_104351.1:n.1063T>C, NR_104349.1:n.1063T>C, NM_001285527.1:c.629T>C, XM_011535851.4:c.629T>C, XM_011535851.3:c.629T>C, XM_011535851.2:c.629T>C, XM_011535851.1:c.629T>C, XM_017010903.3:c.629T>C, XM_017010903.2:c.629T>C, XM_017010903.1:c.629T>C, XM_011535853.3:c.629T>C, XM_011535853.2:c.629T>C, XM_011535853.1:c.629T>C, XM_011535862.3:c.629T>C, XM_011535862.2:c.629T>C, XM_011535862.1:c.629T>C, XM_011535856.3:c.629T>C, XM_011535856.2:c.629T>C, XM_011535856.1:c.629T>C, XM_017010904.2:c.629T>C, XM_017010904.1:c.629T>C, NP_000905.3:p.Ile310Thr, NP_001138751.1:p.Ile403Thr, NP_001138752.1:p.Ile210Thr, NP_001008504.2:p.Ile310Thr, NP_001138759.1:p.Ile210Thr, NP_001138753.1:p.Ile229Thr, NP_001138756.1:p.Ile310Thr, NP_001138758.1:p.Ile310Thr, NP_001008503.2:p.Ile310Thr, NP_001272452.1:p.Ile310Thr, NP_001138757.1:p.Ile310Thr, NP_001272455.1:p.Ile210Thr, NP_001138755.1:p.Ile310Thr, NP_001008505.2:p.Ile310Thr, NP_001138754.1:p.Ile310Thr, NP_001272457.1:p.Ile210Thr, NP_001272453.1:p.Ile403Thr, NP_001272456.1:p.Ile210Thr, XP_011534153.1:p.Ile210Thr, XP_016866392.1:p.Ile210Thr, XP_011534155.1:p.Ile210Thr, XP_011534164.1:p.Ile210Thr, XP_011534158.1:p.Ile210Thr, XP_016866393.1:p.Ile210Thr

    2.

    rs1482798994 [Homo sapiens]
      Variant type:
      SNV
      Alleles:
      C>T [Show Flanks]
      Chromosome:
      6:154091103 (GRCh38)
      6:154412238 (GRCh37)
      Canonical SPDI:
      NC_000006.12:154091102:C:T
      Gene:
      OPRM1 (Varview)
      Functional Consequence:
      coding_sequence_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,synonymous_variant,intron_variant
      Validated:
      by frequency,by alfa,by cluster
      MAF:
      T=0./0 (ALFA)
      T=0.000007/1 (GnomAD)
      T=0.000008/2 (TOPMED)
      HGVS:
      NC_000006.12:g.154091103C>T, NC_000006.11:g.154412238C>T, NG_021208.2:g.85603C>T, NM_000914.5:c.795C>T, NM_000914.4:c.795C>T, NM_000914.3:c.795C>T, NM_001145279.4:c.1074C>T, NM_001145279.3:c.1074C>T, NM_001145279.2:c.1074C>T, NM_001145280.4:c.495C>T, NM_001145280.3:c.495C>T, NM_001145280.2:c.495C>T, NM_001008504.4:c.795C>T, NM_001008504.3:c.795C>T, NM_001008504.2:c.795C>T, NM_001145287.3:c.495C>T, NM_001145287.2:c.495C>T, NM_001145287.1:c.495C>T, NM_001145281.3:c.552C>T, NM_001145281.2:c.552C>T, NM_001145281.1:c.552C>T, NM_001145284.3:c.795C>T, NM_001145284.2:c.795C>T, NM_001145286.3:c.795C>T, NM_001145286.2:c.795C>T, NM_001145286.1:c.795C>T, NM_001008503.3:c.795C>T, NM_001008503.2:c.795C>T, NM_001008503.1:c.795C>T, NM_001285523.3:c.795C>T, NM_001285523.2:c.795C>T, NM_001285523.1:c.795C>T, NM_001145285.3:c.795C>T, NM_001145285.2:c.795C>T, NM_001145285.1:c.795C>T, NM_001285526.2:c.495C>T, NM_001285526.1:c.495C>T, NM_001145283.2:c.795C>T, NM_001145283.1:c.795C>T, NM_001008505.2:c.795C>T, NM_001008505.1:c.795C>T, NM_001145282.2:c.795C>T, NM_001145282.1:c.795C>T, NM_001285528.2:c.495C>T, NM_001285528.1:c.495C>T, NM_001285524.1:c.1074C>T, NR_104348.1:n.929C>T, NR_104350.1:n.576C>T, NR_104351.1:n.929C>T, NR_104349.1:n.929C>T, NM_001285527.1:c.495C>T, XM_011535851.4:c.495C>T, XM_011535851.3:c.495C>T, XM_011535851.2:c.495C>T, XM_011535851.1:c.495C>T, XM_017010903.3:c.495C>T, XM_017010903.2:c.495C>T, XM_017010903.1:c.495C>T, XM_011535853.3:c.495C>T, XM_011535853.2:c.495C>T, XM_011535853.1:c.495C>T, XM_011535862.3:c.495C>T, XM_011535862.2:c.495C>T, XM_011535862.1:c.495C>T, XM_011535856.3:c.495C>T, XM_011535856.2:c.495C>T, XM_011535856.1:c.495C>T, XM_017010904.2:c.495C>T, XM_017010904.1:c.495C>T

      3.

      rs1478259383 [Homo sapiens]
        Variant type:
        DELINS
        Alleles:
        TGGCACTTCT>- [Show Flanks]
        Chromosome:
        6:154091266 (GRCh38)
        6:154412401 (GRCh37)
        Canonical SPDI:
        NC_000006.12:154091261:TTCTTGGCACTTCT:TTCT
        Gene:
        OPRM1 (Varview)
        Functional Consequence:
        coding_sequence_variant,frameshift_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,intron_variant
        Validated:
        by frequency
        MAF:
        -=0.000004/1 (GnomAD_exomes)
        HGVS:
        NC_000006.12:g.154091266_154091275del, NC_000006.11:g.154412401_154412410del, NG_021208.2:g.85766_85775del, NM_000914.5:c.958_967del, NM_000914.4:c.958_967del, NM_000914.3:c.958_967del, NM_001145279.4:c.1237_1246del, NM_001145279.3:c.1237_1246del, NM_001145279.2:c.1237_1246del, NM_001145280.4:c.658_667del, NM_001145280.3:c.658_667del, NM_001145280.2:c.658_667del, NM_001008504.4:c.958_967del, NM_001008504.3:c.958_967del, NM_001008504.2:c.958_967del, NM_001145287.3:c.658_667del, NM_001145287.2:c.658_667del, NM_001145287.1:c.658_667del, NM_001145281.3:c.715_724del, NM_001145281.2:c.715_724del, NM_001145281.1:c.715_724del, NM_001145284.3:c.958_967del, NM_001145284.2:c.958_967del, NM_001145286.3:c.958_967del, NM_001145286.2:c.958_967del, NM_001145286.1:c.958_967del, NM_001008503.3:c.958_967del, NM_001008503.2:c.958_967del, NM_001008503.1:c.958_967del, NM_001285523.3:c.958_967del, NM_001285523.2:c.958_967del, NM_001285523.1:c.958_967del, NM_001145285.3:c.958_967del, NM_001145285.2:c.958_967del, NM_001145285.1:c.958_967del, NM_001285526.2:c.658_667del, NM_001285526.1:c.658_667del, NM_001145283.2:c.958_967del, NM_001145283.1:c.958_967del, NM_001008505.2:c.958_967del, NM_001008505.1:c.958_967del, NM_001145282.2:c.958_967del, NM_001145282.1:c.958_967del, NM_001285528.2:c.658_667del, NM_001285528.1:c.658_667del, NM_001285524.1:c.1237_1246del, NR_104348.1:n.1092_1101del, NR_104350.1:n.739_748del, NR_104351.1:n.1092_1101del, NR_104349.1:n.1092_1101del, NM_001285527.1:c.658_667del, XM_011535851.4:c.658_667del, XM_011535851.3:c.658_667del, XM_011535851.2:c.658_667del, XM_011535851.1:c.658_667del, XM_017010903.3:c.658_667del, XM_017010903.2:c.658_667del, XM_017010903.1:c.658_667del, XM_011535853.3:c.658_667del, XM_011535853.2:c.658_667del, XM_011535853.1:c.658_667del, XM_011535862.3:c.658_667del, XM_011535862.2:c.658_667del, XM_011535862.1:c.658_667del, XM_011535856.3:c.658_667del, XM_011535856.2:c.658_667del, XM_011535856.1:c.658_667del, XM_017010904.2:c.658_667del, XM_017010904.1:c.658_667del, NP_000905.3:p.Trp320fs, NP_001138751.1:p.Trp413fs, NP_001138752.1:p.Trp220fs, NP_001008504.2:p.Trp320fs, NP_001138759.1:p.Trp220fs, NP_001138753.1:p.Trp239fs, NP_001138756.1:p.Trp320fs, NP_001138758.1:p.Trp320fs, NP_001008503.2:p.Trp320fs, NP_001272452.1:p.Trp320fs, NP_001138757.1:p.Trp320fs, NP_001272455.1:p.Trp220fs, NP_001138755.1:p.Trp320fs, NP_001008505.2:p.Trp320fs, NP_001138754.1:p.Trp320fs, NP_001272457.1:p.Trp220fs, NP_001272453.1:p.Trp413fs, NP_001272456.1:p.Trp220fs, XP_011534153.1:p.Trp220fs, XP_016866392.1:p.Trp220fs, XP_011534155.1:p.Trp220fs, XP_011534164.1:p.Trp220fs, XP_011534158.1:p.Trp220fs, XP_016866393.1:p.Trp220fs

        4.

        rs1477995496 [Homo sapiens]
          Variant type:
          SNV
          Alleles:
          G>A [Show Flanks]
          Chromosome:
          6:154118694 (GRCh38)
          6:154439829 (GRCh37)
          Canonical SPDI:
          NC_000006.12:154118693:G:A
          Gene:
          OPRM1 (Varview)
          Functional Consequence:
          coding_sequence_variant,3_prime_UTR_variant,synonymous_variant,genic_downstream_transcript_variant,non_coding_transcript_variant,intron_variant
          Validated:
          by frequency,by alfa,by cluster
          MAF:
          A=0./0 (ALFA)
          A=0.000007/1 (GnomAD)
          HGVS:

          5.

          rs1475597866 [Homo sapiens]
            Variant type:
            SNV
            Alleles:
            A>G [Show Flanks]
            Chromosome:
            6:154091449 (GRCh38)
            6:154412584 (GRCh37)
            Canonical SPDI:
            NC_000006.12:154091448:A:G
            Gene:
            OPRM1 (Varview)
            Functional Consequence:
            missense_variant,coding_sequence_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,intron_variant
            Validated:
            by frequency
            MAF:
            G=0.000004/1 (GnomAD_exomes)
            HGVS:
            NC_000006.12:g.154091449A>G, NC_000006.11:g.154412584A>G, NG_021208.2:g.85949A>G, NM_000914.5:c.1141A>G, NM_000914.4:c.1141A>G, NM_000914.3:c.1141A>G, NM_001145279.4:c.1420A>G, NM_001145279.3:c.1420A>G, NM_001145279.2:c.1420A>G, NM_001145280.4:c.841A>G, NM_001145280.3:c.841A>G, NM_001145280.2:c.841A>G, NM_001008504.4:c.1141A>G, NM_001008504.3:c.1141A>G, NM_001008504.2:c.1141A>G, NM_001145287.3:c.841A>G, NM_001145287.2:c.841A>G, NM_001145287.1:c.841A>G, NM_001145281.3:c.898A>G, NM_001145281.2:c.898A>G, NM_001145281.1:c.898A>G, NM_001145284.3:c.1141A>G, NM_001145284.2:c.1141A>G, NM_001145286.3:c.1141A>G, NM_001145286.2:c.1141A>G, NM_001145286.1:c.1141A>G, NM_001008503.3:c.1141A>G, NM_001008503.2:c.1141A>G, NM_001008503.1:c.1141A>G, NM_001285523.3:c.1141A>G, NM_001285523.2:c.1141A>G, NM_001285523.1:c.1141A>G, NM_001145285.3:c.1141A>G, NM_001145285.2:c.1141A>G, NM_001145285.1:c.1141A>G, NM_001285526.2:c.841A>G, NM_001285526.1:c.841A>G, NM_001145283.2:c.1141A>G, NM_001145283.1:c.1141A>G, NM_001008505.2:c.1141A>G, NM_001008505.1:c.1141A>G, NM_001145282.2:c.1141A>G, NM_001145282.1:c.1141A>G, NM_001285528.2:c.841A>G, NM_001285528.1:c.841A>G, NM_001285524.1:c.1420A>G, NR_104348.1:n.1275A>G, NR_104350.1:n.922A>G, NR_104351.1:n.1275A>G, NR_104349.1:n.1275A>G, NM_001285527.1:c.841A>G, XM_011535851.4:c.841A>G, XM_011535851.3:c.841A>G, XM_011535851.2:c.841A>G, XM_011535851.1:c.841A>G, XM_017010903.3:c.841A>G, XM_017010903.2:c.841A>G, XM_017010903.1:c.841A>G, XM_011535853.3:c.841A>G, XM_011535853.2:c.841A>G, XM_011535853.1:c.841A>G, XM_011535862.3:c.841A>G, XM_011535862.2:c.841A>G, XM_011535862.1:c.841A>G, XM_011535856.3:c.841A>G, XM_011535856.2:c.841A>G, XM_011535856.1:c.841A>G, XM_017010904.2:c.841A>G, XM_017010904.1:c.841A>G, NP_000905.3:p.Thr381Ala, NP_001138751.1:p.Thr474Ala, NP_001138752.1:p.Thr281Ala, NP_001008504.2:p.Thr381Ala, NP_001138759.1:p.Thr281Ala, NP_001138753.1:p.Thr300Ala, NP_001138756.1:p.Thr381Ala, NP_001138758.1:p.Thr381Ala, NP_001008503.2:p.Thr381Ala, NP_001272452.1:p.Thr381Ala, NP_001138757.1:p.Thr381Ala, NP_001272455.1:p.Thr281Ala, NP_001138755.1:p.Thr381Ala, NP_001008505.2:p.Thr381Ala, NP_001138754.1:p.Thr381Ala, NP_001272457.1:p.Thr281Ala, NP_001272453.1:p.Thr474Ala, NP_001272456.1:p.Thr281Ala, XP_011534153.1:p.Thr281Ala, XP_016866392.1:p.Thr281Ala, XP_011534155.1:p.Thr281Ala, XP_011534164.1:p.Thr281Ala, XP_011534158.1:p.Thr281Ala, XP_016866393.1:p.Thr281Ala

            6.

            rs1474785806 [Homo sapiens]
              Variant type:
              SNV
              Alleles:
              A>C [Show Flanks]
              Chromosome:
              6:154091080 (GRCh38)
              6:154412215 (GRCh37)
              Canonical SPDI:
              NC_000006.12:154091079:A:C
              Gene:
              OPRM1 (Varview)
              Functional Consequence:
              missense_variant,coding_sequence_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,intron_variant
              Validated:
              by frequency
              MAF:
              C=0.000004/1 (GnomAD_exomes)
              HGVS:
              NC_000006.12:g.154091080A>C, NC_000006.11:g.154412215A>C, NG_021208.2:g.85580A>C, NM_000914.5:c.772A>C, NM_000914.4:c.772A>C, NM_000914.3:c.772A>C, NM_001145279.4:c.1051A>C, NM_001145279.3:c.1051A>C, NM_001145279.2:c.1051A>C, NM_001145280.4:c.472A>C, NM_001145280.3:c.472A>C, NM_001145280.2:c.472A>C, NM_001008504.4:c.772A>C, NM_001008504.3:c.772A>C, NM_001008504.2:c.772A>C, NM_001145287.3:c.472A>C, NM_001145287.2:c.472A>C, NM_001145287.1:c.472A>C, NM_001145281.3:c.529A>C, NM_001145281.2:c.529A>C, NM_001145281.1:c.529A>C, NM_001145284.3:c.772A>C, NM_001145284.2:c.772A>C, NM_001145286.3:c.772A>C, NM_001145286.2:c.772A>C, NM_001145286.1:c.772A>C, NM_001008503.3:c.772A>C, NM_001008503.2:c.772A>C, NM_001008503.1:c.772A>C, NM_001285523.3:c.772A>C, NM_001285523.2:c.772A>C, NM_001285523.1:c.772A>C, NM_001145285.3:c.772A>C, NM_001145285.2:c.772A>C, NM_001145285.1:c.772A>C, NM_001285526.2:c.472A>C, NM_001285526.1:c.472A>C, NM_001145283.2:c.772A>C, NM_001145283.1:c.772A>C, NM_001008505.2:c.772A>C, NM_001008505.1:c.772A>C, NM_001145282.2:c.772A>C, NM_001145282.1:c.772A>C, NM_001285528.2:c.472A>C, NM_001285528.1:c.472A>C, NM_001285524.1:c.1051A>C, NR_104348.1:n.906A>C, NR_104350.1:n.553A>C, NR_104351.1:n.906A>C, NR_104349.1:n.906A>C, NM_001285527.1:c.472A>C, XM_011535851.4:c.472A>C, XM_011535851.3:c.472A>C, XM_011535851.2:c.472A>C, XM_011535851.1:c.472A>C, XM_017010903.3:c.472A>C, XM_017010903.2:c.472A>C, XM_017010903.1:c.472A>C, XM_011535853.3:c.472A>C, XM_011535853.2:c.472A>C, XM_011535853.1:c.472A>C, XM_011535862.3:c.472A>C, XM_011535862.2:c.472A>C, XM_011535862.1:c.472A>C, XM_011535856.3:c.472A>C, XM_011535856.2:c.472A>C, XM_011535856.1:c.472A>C, XM_017010904.2:c.472A>C, XM_017010904.1:c.472A>C, NP_000905.3:p.Ile258Leu, NP_001138751.1:p.Ile351Leu, NP_001138752.1:p.Ile158Leu, NP_001008504.2:p.Ile258Leu, NP_001138759.1:p.Ile158Leu, NP_001138753.1:p.Ile177Leu, NP_001138756.1:p.Ile258Leu, NP_001138758.1:p.Ile258Leu, NP_001008503.2:p.Ile258Leu, NP_001272452.1:p.Ile258Leu, NP_001138757.1:p.Ile258Leu, NP_001272455.1:p.Ile158Leu, NP_001138755.1:p.Ile258Leu, NP_001008505.2:p.Ile258Leu, NP_001138754.1:p.Ile258Leu, NP_001272457.1:p.Ile158Leu, NP_001272453.1:p.Ile351Leu, NP_001272456.1:p.Ile158Leu, XP_011534153.1:p.Ile158Leu, XP_016866392.1:p.Ile158Leu, XP_011534155.1:p.Ile158Leu, XP_011534164.1:p.Ile158Leu, XP_011534158.1:p.Ile158Leu, XP_016866393.1:p.Ile158Leu

              7.

              rs1473998431 [Homo sapiens]
                Variant type:
                SNV
                Alleles:
                G>T [Show Flanks]
                Chromosome:
                6:154091154 (GRCh38)
                6:154412289 (GRCh37)
                Canonical SPDI:
                NC_000006.12:154091153:G:T
                Gene:
                OPRM1 (Varview)
                Functional Consequence:
                missense_variant,coding_sequence_variant,non_coding_transcript_variant,genic_downstream_transcript_variant,intron_variant
                Validated:
                by frequency
                MAF:
                T=0.000004/1 (GnomAD_exomes)
                HGVS:
                NC_000006.12:g.154091154G>T, NC_000006.11:g.154412289G>T, NG_021208.2:g.85654G>T, NM_000914.5:c.846G>T, NM_000914.4:c.846G>T, NM_000914.3:c.846G>T, NM_001145279.4:c.1125G>T, NM_001145279.3:c.1125G>T, NM_001145279.2:c.1125G>T, NM_001145280.4:c.546G>T, NM_001145280.3:c.546G>T, NM_001145280.2:c.546G>T, NM_001008504.4:c.846G>T, NM_001008504.3:c.846G>T, NM_001008504.2:c.846G>T, NM_001145287.3:c.546G>T, NM_001145287.2:c.546G>T, NM_001145287.1:c.546G>T, NM_001145281.3:c.603G>T, NM_001145281.2:c.603G>T, NM_001145281.1:c.603G>T, NM_001145284.3:c.846G>T, NM_001145284.2:c.846G>T, NM_001145286.3:c.846G>T, NM_001145286.2:c.846G>T, NM_001145286.1:c.846G>T, NM_001008503.3:c.846G>T, NM_001008503.2:c.846G>T, NM_001008503.1:c.846G>T, NM_001285523.3:c.846G>T, NM_001285523.2:c.846G>T, NM_001285523.1:c.846G>T, NM_001145285.3:c.846G>T, NM_001145285.2:c.846G>T, NM_001145285.1:c.846G>T, NM_001285526.2:c.546G>T, NM_001285526.1:c.546G>T, NM_001145283.2:c.846G>T, NM_001145283.1:c.846G>T, NM_001008505.2:c.846G>T, NM_001008505.1:c.846G>T, NM_001145282.2:c.846G>T, NM_001145282.1:c.846G>T, NM_001285528.2:c.546G>T, NM_001285528.1:c.546G>T, NM_001285524.1:c.1125G>T, NR_104348.1:n.980G>T, NR_104350.1:n.627G>T, NR_104351.1:n.980G>T, NR_104349.1:n.980G>T, NM_001285527.1:c.546G>T, XM_011535851.4:c.546G>T, XM_011535851.3:c.546G>T, XM_011535851.2:c.546G>T, XM_011535851.1:c.546G>T, XM_017010903.3:c.546G>T, XM_017010903.2:c.546G>T, XM_017010903.1:c.546G>T, XM_011535853.3:c.546G>T, XM_011535853.2:c.546G>T, XM_011535853.1:c.546G>T, XM_011535862.3:c.546G>T, XM_011535862.2:c.546G>T, XM_011535862.1:c.546G>T, XM_011535856.3:c.546G>T, XM_011535856.2:c.546G>T, XM_011535856.1:c.546G>T, XM_017010904.2:c.546G>T, XM_017010904.1:c.546G>T, NP_000905.3:p.Arg282Ser, NP_001138751.1:p.Arg375Ser, NP_001138752.1:p.Arg182Ser, NP_001008504.2:p.Arg282Ser, NP_001138759.1:p.Arg182Ser, NP_001138753.1:p.Arg201Ser, NP_001138756.1:p.Arg282Ser, NP_001138758.1:p.Arg282Ser, NP_001008503.2:p.Arg282Ser, NP_001272452.1:p.Arg282Ser, NP_001138757.1:p.Arg282Ser, NP_001272455.1:p.Arg182Ser, NP_001138755.1:p.Arg282Ser, NP_001008505.2:p.Arg282Ser, NP_001138754.1:p.Arg282Ser, NP_001272457.1:p.Arg182Ser, NP_001272453.1:p.Arg375Ser, NP_001272456.1:p.Arg182Ser, XP_011534153.1:p.Arg182Ser, XP_016866392.1:p.Arg182Ser, XP_011534155.1:p.Arg182Ser, XP_011534164.1:p.Arg182Ser, XP_011534158.1:p.Arg182Ser, XP_016866393.1:p.Arg182Ser

                8.

                rs1463986793 [Homo sapiens]
                  Variant type:
                  SNV
                  Alleles:
                  A>C [Show Flanks]
                  Chromosome:
                  6:154090096 (GRCh38)
                  6:154411231 (GRCh37)
                  Canonical SPDI:
                  NC_000006.12:154090095:A:C
                  Gene:
                  OPRM1 (Varview)
                  Functional Consequence:
                  non_coding_transcript_variant,3_prime_UTR_variant,missense_variant,intron_variant,genic_downstream_transcript_variant,coding_sequence_variant
                  Validated:
                  by frequency,by alfa
                  MAF:
                  C=0./0 (ALFA)
                  C=0.000004/1 (TOPMED)
                  HGVS:
                  NC_000006.12:g.154090096A>C, NC_000006.11:g.154411231A>C, NG_021208.2:g.84596A>C, NM_000914.5:c.561A>C, NM_000914.4:c.561A>C, NM_000914.3:c.561A>C, NM_001145279.4:c.840A>C, NM_001145279.3:c.840A>C, NM_001145279.2:c.840A>C, NM_001145280.4:c.261A>C, NM_001145280.3:c.261A>C, NM_001145280.2:c.261A>C, NM_001008504.4:c.561A>C, NM_001008504.3:c.561A>C, NM_001008504.2:c.561A>C, NM_001145287.3:c.261A>C, NM_001145287.2:c.261A>C, NM_001145287.1:c.261A>C, NM_001145281.3:c.318A>C, NM_001145281.2:c.318A>C, NM_001145281.1:c.318A>C, NM_001145284.3:c.561A>C, NM_001145284.2:c.561A>C, NM_001145286.3:c.561A>C, NM_001145286.2:c.561A>C, NM_001145286.1:c.561A>C, NM_001008503.3:c.561A>C, NM_001008503.2:c.561A>C, NM_001008503.1:c.561A>C, NM_001285523.3:c.561A>C, NM_001285523.2:c.561A>C, NM_001285523.1:c.561A>C, NM_001145285.3:c.561A>C, NM_001145285.2:c.561A>C, NM_001145285.1:c.561A>C, NM_001285526.2:c.261A>C, NM_001285526.1:c.261A>C, NM_001145283.2:c.561A>C, NM_001145283.1:c.561A>C, NM_001008505.2:c.561A>C, NM_001008505.1:c.561A>C, NM_001145282.2:c.561A>C, NM_001145282.1:c.561A>C, NM_001285528.2:c.261A>C, NM_001285528.1:c.261A>C, NM_001285524.1:c.840A>C, NR_104348.1:n.695A>C, NR_104351.1:n.695A>C, NR_104349.1:n.695A>C, NM_001285527.1:c.261A>C, XM_011535851.4:c.261A>C, XM_011535851.3:c.261A>C, XM_011535851.2:c.261A>C, XM_011535851.1:c.261A>C, XM_017010903.3:c.261A>C, XM_017010903.2:c.261A>C, XM_017010903.1:c.261A>C, XM_011535853.3:c.261A>C, XM_011535853.2:c.261A>C, XM_011535853.1:c.261A>C, XM_011535862.3:c.261A>C, XM_011535862.2:c.261A>C, XM_011535862.1:c.261A>C, XM_011535856.3:c.261A>C, XM_011535856.2:c.261A>C, XM_011535856.1:c.261A>C, XM_017010904.2:c.261A>C, XM_017010904.1:c.261A>C, XM_047418837.1:c.*106A>C, NP_000905.3:p.Lys187Asn, NP_001138751.1:p.Lys280Asn, NP_001138752.1:p.Lys87Asn, NP_001008504.2:p.Lys187Asn, NP_001138759.1:p.Lys87Asn, NP_001138753.1:p.Lys106Asn, NP_001138756.1:p.Lys187Asn, NP_001138758.1:p.Lys187Asn, NP_001008503.2:p.Lys187Asn, NP_001272452.1:p.Lys187Asn, NP_001138757.1:p.Lys187Asn, NP_001272455.1:p.Lys87Asn, NP_001138755.1:p.Lys187Asn, NP_001008505.2:p.Lys187Asn, NP_001138754.1:p.Lys187Asn, NP_001272457.1:p.Lys87Asn, NP_001272453.1:p.Lys280Asn, NP_001272456.1:p.Lys87Asn, XP_011534153.1:p.Lys87Asn, XP_016866392.1:p.Lys87Asn, XP_011534155.1:p.Lys87Asn, XP_011534164.1:p.Lys87Asn, XP_011534158.1:p.Lys87Asn, XP_016866393.1:p.Lys87Asn

                  9.

                  rs1463282853 [Homo sapiens]
                    Variant type:
                    SNV
                    Alleles:
                    C>A [Show Flanks]
                    Chromosome:
                    6:154090013 (GRCh38)
                    6:154411148 (GRCh37)
                    Canonical SPDI:
                    NC_000006.12:154090012:C:A
                    Gene:
                    OPRM1 (Varview)
                    Functional Consequence:
                    non_coding_transcript_variant,3_prime_UTR_variant,missense_variant,intron_variant,genic_downstream_transcript_variant,coding_sequence_variant
                    Validated:
                    by frequency,by alfa,by cluster
                    MAF:
                    A=0./0 (ALFA)
                    A=0.000004/1 (TOPMED)
                    A=0.000007/1 (GnomAD)
                    HGVS:
                    NC_000006.12:g.154090013C>A, NC_000006.11:g.154411148C>A, NG_021208.2:g.84513C>A, NM_000914.5:c.478C>A, NM_000914.4:c.478C>A, NM_000914.3:c.478C>A, NM_001145279.4:c.757C>A, NM_001145279.3:c.757C>A, NM_001145279.2:c.757C>A, NM_001145280.4:c.178C>A, NM_001145280.3:c.178C>A, NM_001145280.2:c.178C>A, NM_001008504.4:c.478C>A, NM_001008504.3:c.478C>A, NM_001008504.2:c.478C>A, NM_001145287.3:c.178C>A, NM_001145287.2:c.178C>A, NM_001145287.1:c.178C>A, NM_001145281.3:c.235C>A, NM_001145281.2:c.235C>A, NM_001145281.1:c.235C>A, NM_001145284.3:c.478C>A, NM_001145284.2:c.478C>A, NM_001145286.3:c.478C>A, NM_001145286.2:c.478C>A, NM_001145286.1:c.478C>A, NM_001008503.3:c.478C>A, NM_001008503.2:c.478C>A, NM_001008503.1:c.478C>A, NM_001285523.3:c.478C>A, NM_001285523.2:c.478C>A, NM_001285523.1:c.478C>A, NM_001145285.3:c.478C>A, NM_001145285.2:c.478C>A, NM_001145285.1:c.478C>A, NM_001285526.2:c.178C>A, NM_001285526.1:c.178C>A, NM_001145283.2:c.478C>A, NM_001145283.1:c.478C>A, NM_001008505.2:c.478C>A, NM_001008505.1:c.478C>A, NM_001145282.2:c.478C>A, NM_001145282.1:c.478C>A, NM_001285528.2:c.178C>A, NM_001285528.1:c.178C>A, NM_001285524.1:c.757C>A, NR_104348.1:n.612C>A, NR_104351.1:n.612C>A, NR_104349.1:n.612C>A, NM_001285527.1:c.178C>A, XM_011535851.4:c.178C>A, XM_011535851.3:c.178C>A, XM_011535851.2:c.178C>A, XM_011535851.1:c.178C>A, XM_017010903.3:c.178C>A, XM_017010903.2:c.178C>A, XM_017010903.1:c.178C>A, XM_011535853.3:c.178C>A, XM_011535853.2:c.178C>A, XM_011535853.1:c.178C>A, XM_011535862.3:c.178C>A, XM_011535862.2:c.178C>A, XM_011535862.1:c.178C>A, XM_011535856.3:c.178C>A, XM_011535856.2:c.178C>A, XM_011535856.1:c.178C>A, XM_017010904.2:c.178C>A, XM_017010904.1:c.178C>A, XM_047418837.1:c.*23C>A, NP_000905.3:p.Leu160Ile, NP_001138751.1:p.Leu253Ile, NP_001138752.1:p.Leu60Ile, NP_001008504.2:p.Leu160Ile, NP_001138759.1:p.Leu60Ile, NP_001138753.1:p.Leu79Ile, NP_001138756.1:p.Leu160Ile, NP_001138758.1:p.Leu160Ile, NP_001008503.2:p.Leu160Ile, NP_001272452.1:p.Leu160Ile, NP_001138757.1:p.Leu160Ile, NP_001272455.1:p.Leu60Ile, NP_001138755.1:p.Leu160Ile, NP_001008505.2:p.Leu160Ile, NP_001138754.1:p.Leu160Ile, NP_001272457.1:p.Leu60Ile, NP_001272453.1:p.Leu253Ile, NP_001272456.1:p.Leu60Ile, XP_011534153.1:p.Leu60Ile, XP_016866392.1:p.Leu60Ile, XP_011534155.1:p.Leu60Ile, XP_011534164.1:p.Leu60Ile, XP_011534158.1:p.Leu60Ile, XP_016866393.1:p.Leu60Ile

                    10.

                    rs1455793934 [Homo sapiens]
                      Variant type:
                      SNV
                      Alleles:
                      A>G [Show Flanks]
                      Chromosome:
                      6:154010531 (GRCh38)
                      6:154331666 (GRCh37)
                      Canonical SPDI:
                      NC_000006.12:154010530:A:G
                      Gene:
                      OPRM1 (Varview)
                      Functional Consequence:
                      genic_upstream_transcript_variant,coding_sequence_variant,missense_variant,5_prime_UTR_variant
                      HGVS:

                      11.

                      rs1454907521 [Homo sapiens]
                        Variant type:
                        SNV
                        Alleles:
                        G>A [Show Flanks]
                        Chromosome:
                        6:154010546 (GRCh38)
                        6:154331681 (GRCh37)
                        Canonical SPDI:
                        NC_000006.12:154010545:G:A
                        Gene:
                        OPRM1 (Varview)
                        Functional Consequence:
                        genic_upstream_transcript_variant,coding_sequence_variant,missense_variant,5_prime_UTR_variant
                        Validated:
                        by frequency,by alfa,by cluster
                        MAF:
                        A=0.00003/1 (ALFA)
                        A=0.000007/1 (GnomAD)
                        A=0.000007/1 (GnomAD_exomes)
                        HGVS:

                        12.

                        rs1451950575 [Homo sapiens]
                          Variant type:
                          SNV
                          Alleles:
                          T>A,C [Show Flanks]
                          Chromosome:
                          6:154091322 (GRCh38)
                          6:154412457 (GRCh37)
                          Canonical SPDI:
                          NC_000006.12:154091321:T:A,NC_000006.12:154091321:T:C
                          Gene:
                          OPRM1 (Varview)
                          Functional Consequence:
                          non_coding_transcript_variant,synonymous_variant,coding_sequence_variant,intron_variant,genic_downstream_transcript_variant,stop_gained
                          Validated:
                          by frequency,by alfa,by cluster
                          MAF:
                          C=0./0 (ALFA)
                          C=0.000004/1 (GnomAD_exomes)
                          HGVS:
                          NC_000006.12:g.154091322T>A, NC_000006.12:g.154091322T>C, NC_000006.11:g.154412457T>A, NC_000006.11:g.154412457T>C, NG_021208.2:g.85822T>A, NG_021208.2:g.85822T>C, NM_000914.5:c.1014T>A, NM_000914.5:c.1014T>C, NM_000914.4:c.1014T>A, NM_000914.4:c.1014T>C, NM_000914.3:c.1014T>A, NM_000914.3:c.1014T>C, NM_001145279.4:c.1293T>A, NM_001145279.4:c.1293T>C, NM_001145279.3:c.1293T>A, NM_001145279.3:c.1293T>C, NM_001145279.2:c.1293T>A, NM_001145279.2:c.1293T>C, NM_001145280.4:c.714T>A, NM_001145280.4:c.714T>C, NM_001145280.3:c.714T>A, NM_001145280.3:c.714T>C, NM_001145280.2:c.714T>A, NM_001145280.2:c.714T>C, NM_001008504.4:c.1014T>A, NM_001008504.4:c.1014T>C, NM_001008504.3:c.1014T>A, NM_001008504.3:c.1014T>C, NM_001008504.2:c.1014T>A, NM_001008504.2:c.1014T>C, NM_001145287.3:c.714T>A, NM_001145287.3:c.714T>C, NM_001145287.2:c.714T>A, NM_001145287.2:c.714T>C, NM_001145287.1:c.714T>A, NM_001145287.1:c.714T>C, NM_001145281.3:c.771T>A, NM_001145281.3:c.771T>C, NM_001145281.2:c.771T>A, NM_001145281.2:c.771T>C, NM_001145281.1:c.771T>A, NM_001145281.1:c.771T>C, NM_001145284.3:c.1014T>A, NM_001145284.3:c.1014T>C, NM_001145284.2:c.1014T>A, NM_001145284.2:c.1014T>C, NM_001145286.3:c.1014T>A, NM_001145286.3:c.1014T>C, NM_001145286.2:c.1014T>A, NM_001145286.2:c.1014T>C, NM_001145286.1:c.1014T>A, NM_001145286.1:c.1014T>C, NM_001008503.3:c.1014T>A, NM_001008503.3:c.1014T>C, NM_001008503.2:c.1014T>A, NM_001008503.2:c.1014T>C, NM_001008503.1:c.1014T>A, NM_001008503.1:c.1014T>C, NM_001285523.3:c.1014T>A, NM_001285523.3:c.1014T>C, NM_001285523.2:c.1014T>A, NM_001285523.2:c.1014T>C, NM_001285523.1:c.1014T>A, NM_001285523.1:c.1014T>C, NM_001145285.3:c.1014T>A, NM_001145285.3:c.1014T>C, NM_001145285.2:c.1014T>A, NM_001145285.2:c.1014T>C, NM_001145285.1:c.1014T>A, NM_001145285.1:c.1014T>C, NM_001285526.2:c.714T>A, NM_001285526.2:c.714T>C, NM_001285526.1:c.714T>A, NM_001285526.1:c.714T>C, NM_001145283.2:c.1014T>A, NM_001145283.2:c.1014T>C, NM_001145283.1:c.1014T>A, NM_001145283.1:c.1014T>C, NM_001008505.2:c.1014T>A, NM_001008505.2:c.1014T>C, NM_001008505.1:c.1014T>A, NM_001008505.1:c.1014T>C, NM_001145282.2:c.1014T>A, NM_001145282.2:c.1014T>C, NM_001145282.1:c.1014T>A, NM_001145282.1:c.1014T>C, NM_001285528.2:c.714T>A, NM_001285528.2:c.714T>C, NM_001285528.1:c.714T>A, NM_001285528.1:c.714T>C, NM_001285524.1:c.1293T>A, NM_001285524.1:c.1293T>C, NR_104348.1:n.1148T>A, NR_104348.1:n.1148T>C, NR_104350.1:n.795T>A, NR_104350.1:n.795T>C, NR_104351.1:n.1148T>A, NR_104351.1:n.1148T>C, NR_104349.1:n.1148T>A, NR_104349.1:n.1148T>C, NM_001285527.1:c.714T>A, NM_001285527.1:c.714T>C, XM_011535851.4:c.714T>A, XM_011535851.4:c.714T>C, XM_011535851.3:c.714T>A, XM_011535851.3:c.714T>C, XM_011535851.2:c.714T>A, XM_011535851.2:c.714T>C, XM_011535851.1:c.714T>A, XM_011535851.1:c.714T>C, XM_017010903.3:c.714T>A, XM_017010903.3:c.714T>C, XM_017010903.2:c.714T>A, XM_017010903.2:c.714T>C, XM_017010903.1:c.714T>A, XM_017010903.1:c.714T>C, XM_011535853.3:c.714T>A, XM_011535853.3:c.714T>C, XM_011535853.2:c.714T>A, XM_011535853.2:c.714T>C, XM_011535853.1:c.714T>A, XM_011535853.1:c.714T>C, XM_011535862.3:c.714T>A, XM_011535862.3:c.714T>C, XM_011535862.2:c.714T>A, XM_011535862.2:c.714T>C, XM_011535862.1:c.714T>A, XM_011535862.1:c.714T>C, XM_011535856.3:c.714T>A, XM_011535856.3:c.714T>C, XM_011535856.2:c.714T>A, XM_011535856.2:c.714T>C, XM_011535856.1:c.714T>A, XM_011535856.1:c.714T>C, XM_017010904.2:c.714T>A, XM_017010904.2:c.714T>C, XM_017010904.1:c.714T>A, XM_017010904.1:c.714T>C, NP_000905.3:p.Tyr338Ter, NP_001138751.1:p.Tyr431Ter, NP_001138752.1:p.Tyr238Ter, NP_001008504.2:p.Tyr338Ter, NP_001138759.1:p.Tyr238Ter, NP_001138753.1:p.Tyr257Ter, NP_001138756.1:p.Tyr338Ter, NP_001138758.1:p.Tyr338Ter, NP_001008503.2:p.Tyr338Ter, NP_001272452.1:p.Tyr338Ter, NP_001138757.1:p.Tyr338Ter, NP_001272455.1:p.Tyr238Ter, NP_001138755.1:p.Tyr338Ter, NP_001008505.2:p.Tyr338Ter, NP_001138754.1:p.Tyr338Ter, NP_001272457.1:p.Tyr238Ter, NP_001272453.1:p.Tyr431Ter, NP_001272456.1:p.Tyr238Ter, XP_011534153.1:p.Tyr238Ter, XP_016866392.1:p.Tyr238Ter, XP_011534155.1:p.Tyr238Ter, XP_011534164.1:p.Tyr238Ter, XP_011534158.1:p.Tyr238Ter, XP_016866393.1:p.Tyr238Ter

                          13.

                          rs1448672250 [Homo sapiens]
                            Variant type:
                            SNV
                            Alleles:
                            C>T [Show Flanks]
                            Chromosome:
                            6:154010533 (GRCh38)
                            6:154331668 (GRCh37)
                            Canonical SPDI:
                            NC_000006.12:154010532:C:T
                            Gene:
                            OPRM1 (Varview)
                            Functional Consequence:
                            coding_sequence_variant,synonymous_variant,5_prime_UTR_variant,genic_upstream_transcript_variant
                            Validated:
                            by frequency,by alfa,by cluster
                            MAF:
                            T=0.000071/1 (ALFA)
                            T=0.000004/1 (TOPMED)
                            HGVS:

                            14.

                            rs1442015751 [Homo sapiens]
                              Variant type:
                              SNV
                              Alleles:
                              A>G [Show Flanks]
                              Chromosome:
                              6:154091349 (GRCh38)
                              6:154412484 (GRCh37)
                              Canonical SPDI:
                              NC_000006.12:154091348:A:G
                              Gene:
                              OPRM1 (Varview)
                              Functional Consequence:
                              non_coding_transcript_variant,synonymous_variant,coding_sequence_variant,intron_variant,genic_downstream_transcript_variant
                              Validated:
                              by frequency
                              MAF:
                              G=0.000008/2 (GnomAD_exomes)
                              HGVS:
                              NC_000006.12:g.154091349A>G, NC_000006.11:g.154412484A>G, NG_021208.2:g.85849A>G, NM_000914.5:c.1041A>G, NM_000914.4:c.1041A>G, NM_000914.3:c.1041A>G, NM_001145279.4:c.1320A>G, NM_001145279.3:c.1320A>G, NM_001145279.2:c.1320A>G, NM_001145280.4:c.741A>G, NM_001145280.3:c.741A>G, NM_001145280.2:c.741A>G, NM_001008504.4:c.1041A>G, NM_001008504.3:c.1041A>G, NM_001008504.2:c.1041A>G, NM_001145287.3:c.741A>G, NM_001145287.2:c.741A>G, NM_001145287.1:c.741A>G, NM_001145281.3:c.798A>G, NM_001145281.2:c.798A>G, NM_001145281.1:c.798A>G, NM_001145284.3:c.1041A>G, NM_001145284.2:c.1041A>G, NM_001145286.3:c.1041A>G, NM_001145286.2:c.1041A>G, NM_001145286.1:c.1041A>G, NM_001008503.3:c.1041A>G, NM_001008503.2:c.1041A>G, NM_001008503.1:c.1041A>G, NM_001285523.3:c.1041A>G, NM_001285523.2:c.1041A>G, NM_001285523.1:c.1041A>G, NM_001145285.3:c.1041A>G, NM_001145285.2:c.1041A>G, NM_001145285.1:c.1041A>G, NM_001285526.2:c.741A>G, NM_001285526.1:c.741A>G, NM_001145283.2:c.1041A>G, NM_001145283.1:c.1041A>G, NM_001008505.2:c.1041A>G, NM_001008505.1:c.1041A>G, NM_001145282.2:c.1041A>G, NM_001145282.1:c.1041A>G, NM_001285528.2:c.741A>G, NM_001285528.1:c.741A>G, NM_001285524.1:c.1320A>G, NR_104348.1:n.1175A>G, NR_104350.1:n.822A>G, NR_104351.1:n.1175A>G, NR_104349.1:n.1175A>G, NM_001285527.1:c.741A>G, XM_011535851.4:c.741A>G, XM_011535851.3:c.741A>G, XM_011535851.2:c.741A>G, XM_011535851.1:c.741A>G, XM_017010903.3:c.741A>G, XM_017010903.2:c.741A>G, XM_017010903.1:c.741A>G, XM_011535853.3:c.741A>G, XM_011535853.2:c.741A>G, XM_011535853.1:c.741A>G, XM_011535862.3:c.741A>G, XM_011535862.2:c.741A>G, XM_011535862.1:c.741A>G, XM_011535856.3:c.741A>G, XM_011535856.2:c.741A>G, XM_011535856.1:c.741A>G, XM_017010904.2:c.741A>G, XM_017010904.1:c.741A>G

                              15.

                              rs1441199275 [Homo sapiens]
                                Variant type:
                                DEL
                                Alleles:
                                T>- [Show Flanks]
                                Chromosome:
                                6:154089857 (GRCh38)
                                6:154410992 (GRCh37)
                                Canonical SPDI:
                                NC_000006.12:154089856:T:
                                Gene:
                                OPRM1 (Varview)
                                Functional Consequence:
                                intron_variant,frameshift_variant,genic_downstream_transcript_variant,coding_sequence_variant,non_coding_transcript_variant
                                Validated:
                                by frequency,by alfa,by cluster
                                MAF:
                                -=0./0 (ALFA)
                                -=0.000004/1 (GnomAD_exomes)
                                -=0.000004/1 (TOPMED)
                                -=0.000007/1 (GnomAD)
                                HGVS:
                                NC_000006.12:g.154089857del, NC_000006.11:g.154410992del, NG_021208.2:g.84357del, NM_000914.5:c.322del, NM_000914.4:c.322del, NM_000914.3:c.322del, NM_001145279.4:c.601del, NM_001145279.3:c.601del, NM_001145279.2:c.601del, NM_001145280.4:c.22del, NM_001145280.3:c.22del, NM_001145280.2:c.22del, NM_001008504.4:c.322del, NM_001008504.3:c.322del, NM_001008504.2:c.322del, NM_001145287.3:c.22del, NM_001145287.2:c.22del, NM_001145287.1:c.22del, NM_001145281.3:c.79del, NM_001145281.2:c.79del, NM_001145281.1:c.79del, NM_001145284.3:c.322del, NM_001145284.2:c.322del, NM_001145286.3:c.322del, NM_001145286.2:c.322del, NM_001145286.1:c.322del, NM_001008503.3:c.322del, NM_001008503.2:c.322del, NM_001008503.1:c.322del, NM_001285523.3:c.322del, NM_001285523.2:c.322del, NM_001285523.1:c.322del, NM_001145285.3:c.322del, NM_001145285.2:c.322del, NM_001145285.1:c.322del, NM_001285526.2:c.22del, NM_001285526.1:c.22del, NM_001145283.2:c.322del, NM_001145283.1:c.322del, NM_001008505.2:c.322del, NM_001008505.1:c.322del, NM_001145282.2:c.322del, NM_001145282.1:c.322del, NM_001285528.2:c.22del, NM_001285528.1:c.22del, NM_001285524.1:c.601del, NR_104348.1:n.456del, NR_104351.1:n.456del, NR_104349.1:n.456del, NM_001285527.1:c.22del, XM_011535851.4:c.22del, XM_011535851.3:c.22del, XM_011535851.2:c.22del, XM_011535851.1:c.22del, XM_017010903.3:c.22del, XM_017010903.2:c.22del, XM_017010903.1:c.22del, XM_011535853.3:c.22del, XM_011535853.2:c.22del, XM_011535853.1:c.22del, XM_011535862.3:c.22del, XM_011535862.2:c.22del, XM_011535862.1:c.22del, XM_011535856.3:c.22del, XM_011535856.2:c.22del, XM_011535856.1:c.22del, XM_017010904.2:c.22del, XM_017010904.1:c.22del, XM_047418837.1:c.581del, NP_000905.3:p.Tyr108fs, NP_001138751.1:p.Tyr201fs, NP_001138752.1:p.Tyr8fs, NP_001008504.2:p.Tyr108fs, NP_001138759.1:p.Tyr8fs, NP_001138753.1:p.Tyr27fs, NP_001138756.1:p.Tyr108fs, NP_001138758.1:p.Tyr108fs, NP_001008503.2:p.Tyr108fs, NP_001272452.1:p.Tyr108fs, NP_001138757.1:p.Tyr108fs, NP_001272455.1:p.Tyr8fs, NP_001138755.1:p.Tyr108fs, NP_001008505.2:p.Tyr108fs, NP_001138754.1:p.Tyr108fs, NP_001272457.1:p.Tyr8fs, NP_001272453.1:p.Tyr201fs, NP_001272456.1:p.Tyr8fs, XP_011534153.1:p.Tyr8fs, XP_016866392.1:p.Tyr8fs, XP_011534155.1:p.Tyr8fs, XP_011534164.1:p.Tyr8fs, XP_011534158.1:p.Tyr8fs, XP_016866393.1:p.Tyr8fs, XP_047274793.1:p.Leu194fs

                                16.

                                rs1434620396 [Homo sapiens]
                                  Variant type:
                                  SNV
                                  Alleles:
                                  T>C [Show Flanks]
                                  Chromosome:
                                  6:154091040 (GRCh38)
                                  6:154412175 (GRCh37)
                                  Canonical SPDI:
                                  NC_000006.12:154091039:T:C
                                  Gene:
                                  OPRM1 (Varview)
                                  Functional Consequence:
                                  intron_variant,synonymous_variant,genic_downstream_transcript_variant,coding_sequence_variant,non_coding_transcript_variant
                                  Validated:
                                  by frequency,by alfa,by cluster
                                  MAF:
                                  C=0.000056/2 (ALFA)
                                  C=0.000023/6 (TOPMED)
                                  C=0.000029/4 (GnomAD)
                                  HGVS:
                                  NC_000006.12:g.154091040T>C, NC_000006.11:g.154412175T>C, NG_021208.2:g.85540T>C, NM_000914.5:c.732T>C, NM_000914.4:c.732T>C, NM_000914.3:c.732T>C, NM_001145279.4:c.1011T>C, NM_001145279.3:c.1011T>C, NM_001145279.2:c.1011T>C, NM_001145280.4:c.432T>C, NM_001145280.3:c.432T>C, NM_001145280.2:c.432T>C, NM_001008504.4:c.732T>C, NM_001008504.3:c.732T>C, NM_001008504.2:c.732T>C, NM_001145287.3:c.432T>C, NM_001145287.2:c.432T>C, NM_001145287.1:c.432T>C, NM_001145281.3:c.489T>C, NM_001145281.2:c.489T>C, NM_001145281.1:c.489T>C, NM_001145284.3:c.732T>C, NM_001145284.2:c.732T>C, NM_001145286.3:c.732T>C, NM_001145286.2:c.732T>C, NM_001145286.1:c.732T>C, NM_001008503.3:c.732T>C, NM_001008503.2:c.732T>C, NM_001008503.1:c.732T>C, NM_001285523.3:c.732T>C, NM_001285523.2:c.732T>C, NM_001285523.1:c.732T>C, NM_001145285.3:c.732T>C, NM_001145285.2:c.732T>C, NM_001145285.1:c.732T>C, NM_001285526.2:c.432T>C, NM_001285526.1:c.432T>C, NM_001145283.2:c.732T>C, NM_001145283.1:c.732T>C, NM_001008505.2:c.732T>C, NM_001008505.1:c.732T>C, NM_001145282.2:c.732T>C, NM_001145282.1:c.732T>C, NM_001285528.2:c.432T>C, NM_001285528.1:c.432T>C, NM_001285524.1:c.1011T>C, NR_104348.1:n.866T>C, NR_104350.1:n.513T>C, NR_104351.1:n.866T>C, NR_104349.1:n.866T>C, NM_001285527.1:c.432T>C, XM_011535851.4:c.432T>C, XM_011535851.3:c.432T>C, XM_011535851.2:c.432T>C, XM_011535851.1:c.432T>C, XM_017010903.3:c.432T>C, XM_017010903.2:c.432T>C, XM_017010903.1:c.432T>C, XM_011535853.3:c.432T>C, XM_011535853.2:c.432T>C, XM_011535853.1:c.432T>C, XM_011535862.3:c.432T>C, XM_011535862.2:c.432T>C, XM_011535862.1:c.432T>C, XM_011535856.3:c.432T>C, XM_011535856.2:c.432T>C, XM_011535856.1:c.432T>C, XM_017010904.2:c.432T>C, XM_017010904.1:c.432T>C

                                  17.

                                  rs1434259576 [Homo sapiens]
                                    Variant type:
                                    DEL
                                    Alleles:
                                    AACCTTGCTCTGGCA>- [Show Flanks]
                                    Chromosome:
                                    6:154089866 (GRCh38)
                                    6:154411001 (GRCh37)
                                    Canonical SPDI:
                                    NC_000006.12:154089865:AACCTTGCTCTGGCA:
                                    Gene:
                                    OPRM1 (Varview)
                                    Functional Consequence:
                                    intron_variant,inframe_deletion,genic_downstream_transcript_variant,coding_sequence_variant,non_coding_transcript_variant
                                    Validated:
                                    by frequency,by alfa
                                    MAF:
                                    -=0./0 (ALFA)
                                    -=0.000004/1 (TOPMED)
                                    HGVS:
                                    NC_000006.12:g.154089866_154089880del, NC_000006.11:g.154411001_154411015del, NG_021208.2:g.84366_84380del, NM_000914.5:c.331_345del, NM_000914.4:c.331_345del, NM_000914.3:c.331_345del, NM_001145279.4:c.610_624del, NM_001145279.3:c.610_624del, NM_001145279.2:c.610_624del, NM_001145280.4:c.31_45del, NM_001145280.3:c.31_45del, NM_001145280.2:c.31_45del, NM_001008504.4:c.331_345del, NM_001008504.3:c.331_345del, NM_001008504.2:c.331_345del, NM_001145287.3:c.31_45del, NM_001145287.2:c.31_45del, NM_001145287.1:c.31_45del, NM_001145281.3:c.88_102del, NM_001145281.2:c.88_102del, NM_001145281.1:c.88_102del, NM_001145284.3:c.331_345del, NM_001145284.2:c.331_345del, NM_001145286.3:c.331_345del, NM_001145286.2:c.331_345del, NM_001145286.1:c.331_345del, NM_001008503.3:c.331_345del, NM_001008503.2:c.331_345del, NM_001008503.1:c.331_345del, NM_001285523.3:c.331_345del, NM_001285523.2:c.331_345del, NM_001285523.1:c.331_345del, NM_001145285.3:c.331_345del, NM_001145285.2:c.331_345del, NM_001145285.1:c.331_345del, NM_001285526.2:c.31_45del, NM_001285526.1:c.31_45del, NM_001145283.2:c.331_345del, NM_001145283.1:c.331_345del, NM_001008505.2:c.331_345del, NM_001008505.1:c.331_345del, NM_001145282.2:c.331_345del, NM_001145282.1:c.331_345del, NM_001285528.2:c.31_45del, NM_001285528.1:c.31_45del, NM_001285524.1:c.610_624del, NR_104348.1:n.465_479del, NR_104351.1:n.465_479del, NR_104349.1:n.465_479del, NM_001285527.1:c.31_45del, XM_011535851.4:c.31_45del, XM_011535851.3:c.31_45del, XM_011535851.2:c.31_45del, XM_011535851.1:c.31_45del, XM_017010903.3:c.31_45del, XM_017010903.2:c.31_45del, XM_017010903.1:c.31_45del, XM_011535853.3:c.31_45del, XM_011535853.2:c.31_45del, XM_011535853.1:c.31_45del, XM_011535862.3:c.31_45del, XM_011535862.2:c.31_45del, XM_011535862.1:c.31_45del, XM_011535856.3:c.31_45del, XM_011535856.2:c.31_45del, XM_011535856.1:c.31_45del, XM_017010904.2:c.31_45del, XM_017010904.1:c.31_45del, XM_047418837.1:c.590_604del, NP_000905.3:p.Asn111_Ala115del, NP_001138751.1:p.Asn204_Ala208del, NP_001138752.1:p.Asn11_Ala15del, NP_001008504.2:p.Asn111_Ala115del, NP_001138759.1:p.Asn11_Ala15del, NP_001138753.1:p.Asn30_Ala34del, NP_001138756.1:p.Asn111_Ala115del, NP_001138758.1:p.Asn111_Ala115del, NP_001008503.2:p.Asn111_Ala115del, NP_001272452.1:p.Asn111_Ala115del, NP_001138757.1:p.Asn111_Ala115del, NP_001272455.1:p.Asn11_Ala15del, NP_001138755.1:p.Asn111_Ala115del, NP_001008505.2:p.Asn111_Ala115del, NP_001138754.1:p.Asn111_Ala115del, NP_001272457.1:p.Asn11_Ala15del, NP_001272453.1:p.Asn204_Ala208del, NP_001272456.1:p.Asn11_Ala15del, XP_011534153.1:p.Asn11_Ala15del, XP_016866392.1:p.Asn11_Ala15del, XP_011534155.1:p.Asn11_Ala15del, XP_011534164.1:p.Asn11_Ala15del, XP_011534158.1:p.Asn11_Ala15del, XP_016866393.1:p.Asn11_Ala15del, XP_047274793.1:p.Gln197_Gly201del

                                    18.

                                    rs1430029215 [Homo sapiens]
                                      Variant type:
                                      SNV
                                      Alleles:
                                      C>G [Show Flanks]
                                      Chromosome:
                                      6:154091111 (GRCh38)
                                      6:154412246 (GRCh37)
                                      Canonical SPDI:
                                      NC_000006.12:154091110:C:G
                                      Gene:
                                      OPRM1 (Varview)
                                      Functional Consequence:
                                      intron_variant,genic_downstream_transcript_variant,coding_sequence_variant,missense_variant,non_coding_transcript_variant
                                      Validated:
                                      by frequency
                                      MAF:
                                      G=0.000004/1 (GnomAD_exomes)
                                      HGVS:
                                      NC_000006.12:g.154091111C>G, NC_000006.11:g.154412246C>G, NG_021208.2:g.85611C>G, NM_000914.5:c.803C>G, NM_000914.4:c.803C>G, NM_000914.3:c.803C>G, NM_001145279.4:c.1082C>G, NM_001145279.3:c.1082C>G, NM_001145279.2:c.1082C>G, NM_001145280.4:c.503C>G, NM_001145280.3:c.503C>G, NM_001145280.2:c.503C>G, NM_001008504.4:c.803C>G, NM_001008504.3:c.803C>G, NM_001008504.2:c.803C>G, NM_001145287.3:c.503C>G, NM_001145287.2:c.503C>G, NM_001145287.1:c.503C>G, NM_001145281.3:c.560C>G, NM_001145281.2:c.560C>G, NM_001145281.1:c.560C>G, NM_001145284.3:c.803C>G, NM_001145284.2:c.803C>G, NM_001145286.3:c.803C>G, NM_001145286.2:c.803C>G, NM_001145286.1:c.803C>G, NM_001008503.3:c.803C>G, NM_001008503.2:c.803C>G, NM_001008503.1:c.803C>G, NM_001285523.3:c.803C>G, NM_001285523.2:c.803C>G, NM_001285523.1:c.803C>G, NM_001145285.3:c.803C>G, NM_001145285.2:c.803C>G, NM_001145285.1:c.803C>G, NM_001285526.2:c.503C>G, NM_001285526.1:c.503C>G, NM_001145283.2:c.803C>G, NM_001145283.1:c.803C>G, NM_001008505.2:c.803C>G, NM_001008505.1:c.803C>G, NM_001145282.2:c.803C>G, NM_001145282.1:c.803C>G, NM_001285528.2:c.503C>G, NM_001285528.1:c.503C>G, NM_001285524.1:c.1082C>G, NR_104348.1:n.937C>G, NR_104350.1:n.584C>G, NR_104351.1:n.937C>G, NR_104349.1:n.937C>G, NM_001285527.1:c.503C>G, XM_011535851.4:c.503C>G, XM_011535851.3:c.503C>G, XM_011535851.2:c.503C>G, XM_011535851.1:c.503C>G, XM_017010903.3:c.503C>G, XM_017010903.2:c.503C>G, XM_017010903.1:c.503C>G, XM_011535853.3:c.503C>G, XM_011535853.2:c.503C>G, XM_011535853.1:c.503C>G, XM_011535862.3:c.503C>G, XM_011535862.2:c.503C>G, XM_011535862.1:c.503C>G, XM_011535856.3:c.503C>G, XM_011535856.2:c.503C>G, XM_011535856.1:c.503C>G, XM_017010904.2:c.503C>G, XM_017010904.1:c.503C>G, NP_000905.3:p.Ser268Cys, NP_001138751.1:p.Ser361Cys, NP_001138752.1:p.Ser168Cys, NP_001008504.2:p.Ser268Cys, NP_001138759.1:p.Ser168Cys, NP_001138753.1:p.Ser187Cys, NP_001138756.1:p.Ser268Cys, NP_001138758.1:p.Ser268Cys, NP_001008503.2:p.Ser268Cys, NP_001272452.1:p.Ser268Cys, NP_001138757.1:p.Ser268Cys, NP_001272455.1:p.Ser168Cys, NP_001138755.1:p.Ser268Cys, NP_001008505.2:p.Ser268Cys, NP_001138754.1:p.Ser268Cys, NP_001272457.1:p.Ser168Cys, NP_001272453.1:p.Ser361Cys, NP_001272456.1:p.Ser168Cys, XP_011534153.1:p.Ser168Cys, XP_016866392.1:p.Ser168Cys, XP_011534155.1:p.Ser168Cys, XP_011534164.1:p.Ser168Cys, XP_011534158.1:p.Ser168Cys, XP_016866393.1:p.Ser168Cys

                                      19.

                                      rs1416806374 [Homo sapiens]
                                        Variant type:
                                        SNV
                                        Alleles:
                                        G>A [Show Flanks]
                                        Chromosome:
                                        6:154091043 (GRCh38)
                                        6:154412178 (GRCh37)
                                        Canonical SPDI:
                                        NC_000006.12:154091042:G:A
                                        Gene:
                                        OPRM1 (Varview)
                                        Functional Consequence:
                                        missense_variant,genic_downstream_transcript_variant,coding_sequence_variant,intron_variant,non_coding_transcript_variant
                                        Validated:
                                        by frequency
                                        MAF:
                                        A=0.000004/1 (GnomAD_exomes)
                                        HGVS:
                                        NC_000006.12:g.154091043G>A, NC_000006.11:g.154412178G>A, NG_021208.2:g.85543G>A, NM_000914.5:c.735G>A, NM_000914.4:c.735G>A, NM_000914.3:c.735G>A, NM_001145279.4:c.1014G>A, NM_001145279.3:c.1014G>A, NM_001145279.2:c.1014G>A, NM_001145280.4:c.435G>A, NM_001145280.3:c.435G>A, NM_001145280.2:c.435G>A, NM_001008504.4:c.735G>A, NM_001008504.3:c.735G>A, NM_001008504.2:c.735G>A, NM_001145287.3:c.435G>A, NM_001145287.2:c.435G>A, NM_001145287.1:c.435G>A, NM_001145281.3:c.492G>A, NM_001145281.2:c.492G>A, NM_001145281.1:c.492G>A, NM_001145284.3:c.735G>A, NM_001145284.2:c.735G>A, NM_001145286.3:c.735G>A, NM_001145286.2:c.735G>A, NM_001145286.1:c.735G>A, NM_001008503.3:c.735G>A, NM_001008503.2:c.735G>A, NM_001008503.1:c.735G>A, NM_001285523.3:c.735G>A, NM_001285523.2:c.735G>A, NM_001285523.1:c.735G>A, NM_001145285.3:c.735G>A, NM_001145285.2:c.735G>A, NM_001145285.1:c.735G>A, NM_001285526.2:c.435G>A, NM_001285526.1:c.435G>A, NM_001145283.2:c.735G>A, NM_001145283.1:c.735G>A, NM_001008505.2:c.735G>A, NM_001008505.1:c.735G>A, NM_001145282.2:c.735G>A, NM_001145282.1:c.735G>A, NM_001285528.2:c.435G>A, NM_001285528.1:c.435G>A, NM_001285524.1:c.1014G>A, NR_104348.1:n.869G>A, NR_104350.1:n.516G>A, NR_104351.1:n.869G>A, NR_104349.1:n.869G>A, NM_001285527.1:c.435G>A, XM_011535851.4:c.435G>A, XM_011535851.3:c.435G>A, XM_011535851.2:c.435G>A, XM_011535851.1:c.435G>A, XM_017010903.3:c.435G>A, XM_017010903.2:c.435G>A, XM_017010903.1:c.435G>A, XM_011535853.3:c.435G>A, XM_011535853.2:c.435G>A, XM_011535853.1:c.435G>A, XM_011535862.3:c.435G>A, XM_011535862.2:c.435G>A, XM_011535862.1:c.435G>A, XM_011535856.3:c.435G>A, XM_011535856.2:c.435G>A, XM_011535856.1:c.435G>A, XM_017010904.2:c.435G>A, XM_017010904.1:c.435G>A, NP_000905.3:p.Met245Ile, NP_001138751.1:p.Met338Ile, NP_001138752.1:p.Met145Ile, NP_001008504.2:p.Met245Ile, NP_001138759.1:p.Met145Ile, NP_001138753.1:p.Met164Ile, NP_001138756.1:p.Met245Ile, NP_001138758.1:p.Met245Ile, NP_001008503.2:p.Met245Ile, NP_001272452.1:p.Met245Ile, NP_001138757.1:p.Met245Ile, NP_001272455.1:p.Met145Ile, NP_001138755.1:p.Met245Ile, NP_001008505.2:p.Met245Ile, NP_001138754.1:p.Met245Ile, NP_001272457.1:p.Met145Ile, NP_001272453.1:p.Met338Ile, NP_001272456.1:p.Met145Ile, XP_011534153.1:p.Met145Ile, XP_016866392.1:p.Met145Ile, XP_011534155.1:p.Met145Ile, XP_011534164.1:p.Met145Ile, XP_011534158.1:p.Met145Ile, XP_016866393.1:p.Met145Ile

                                        20.

                                        rs1412224107 [Homo sapiens]
                                          Variant type:
                                          SNV
                                          Alleles:
                                          C>G [Show Flanks]
                                          Chromosome:
                                          6:154091312 (GRCh38)
                                          6:154412447 (GRCh37)
                                          Canonical SPDI:
                                          NC_000006.12:154091311:C:G
                                          Gene:
                                          OPRM1 (Varview)
                                          Functional Consequence:
                                          missense_variant,genic_downstream_transcript_variant,coding_sequence_variant,intron_variant,non_coding_transcript_variant
                                          Validated:
                                          by frequency,by alfa,by cluster
                                          MAF:
                                          G=0./0 (ALFA)
                                          G=0.000004/1 (TOPMED)
                                          G=0.000007/1 (GnomAD)
                                          HGVS:
                                          NC_000006.12:g.154091312C>G, NC_000006.11:g.154412447C>G, NG_021208.2:g.85812C>G, NM_000914.5:c.1004C>G, NM_000914.4:c.1004C>G, NM_000914.3:c.1004C>G, NM_001145279.4:c.1283C>G, NM_001145279.3:c.1283C>G, NM_001145279.2:c.1283C>G, NM_001145280.4:c.704C>G, NM_001145280.3:c.704C>G, NM_001145280.2:c.704C>G, NM_001008504.4:c.1004C>G, NM_001008504.3:c.1004C>G, NM_001008504.2:c.1004C>G, NM_001145287.3:c.704C>G, NM_001145287.2:c.704C>G, NM_001145287.1:c.704C>G, NM_001145281.3:c.761C>G, NM_001145281.2:c.761C>G, NM_001145281.1:c.761C>G, NM_001145284.3:c.1004C>G, NM_001145284.2:c.1004C>G, NM_001145286.3:c.1004C>G, NM_001145286.2:c.1004C>G, NM_001145286.1:c.1004C>G, NM_001008503.3:c.1004C>G, NM_001008503.2:c.1004C>G, NM_001008503.1:c.1004C>G, NM_001285523.3:c.1004C>G, NM_001285523.2:c.1004C>G, NM_001285523.1:c.1004C>G, NM_001145285.3:c.1004C>G, NM_001145285.2:c.1004C>G, NM_001145285.1:c.1004C>G, NM_001285526.2:c.704C>G, NM_001285526.1:c.704C>G, NM_001145283.2:c.1004C>G, NM_001145283.1:c.1004C>G, NM_001008505.2:c.1004C>G, NM_001008505.1:c.1004C>G, NM_001145282.2:c.1004C>G, NM_001145282.1:c.1004C>G, NM_001285528.2:c.704C>G, NM_001285528.1:c.704C>G, NM_001285524.1:c.1283C>G, NR_104348.1:n.1138C>G, NR_104350.1:n.785C>G, NR_104351.1:n.1138C>G, NR_104349.1:n.1138C>G, NM_001285527.1:c.704C>G, XM_011535851.4:c.704C>G, XM_011535851.3:c.704C>G, XM_011535851.2:c.704C>G, XM_011535851.1:c.704C>G, XM_017010903.3:c.704C>G, XM_017010903.2:c.704C>G, XM_017010903.1:c.704C>G, XM_011535853.3:c.704C>G, XM_011535853.2:c.704C>G, XM_011535853.1:c.704C>G, XM_011535862.3:c.704C>G, XM_011535862.2:c.704C>G, XM_011535862.1:c.704C>G, XM_011535856.3:c.704C>G, XM_011535856.2:c.704C>G, XM_011535856.1:c.704C>G, XM_017010904.2:c.704C>G, XM_017010904.1:c.704C>G, NP_000905.3:p.Pro335Arg, NP_001138751.1:p.Pro428Arg, NP_001138752.1:p.Pro235Arg, NP_001008504.2:p.Pro335Arg, NP_001138759.1:p.Pro235Arg, NP_001138753.1:p.Pro254Arg, NP_001138756.1:p.Pro335Arg, NP_001138758.1:p.Pro335Arg, NP_001008503.2:p.Pro335Arg, NP_001272452.1:p.Pro335Arg, NP_001138757.1:p.Pro335Arg, NP_001272455.1:p.Pro235Arg, NP_001138755.1:p.Pro335Arg, NP_001008505.2:p.Pro335Arg, NP_001138754.1:p.Pro335Arg, NP_001272457.1:p.Pro235Arg, NP_001272453.1:p.Pro428Arg, NP_001272456.1:p.Pro235Arg, XP_011534153.1:p.Pro235Arg, XP_016866392.1:p.Pro235Arg, XP_011534155.1:p.Pro235Arg, XP_011534164.1:p.Pro235Arg, XP_011534158.1:p.Pro235Arg, XP_016866393.1:p.Pro235Arg

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