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Design: Multiazole resistance in clinical and environmental fungal isolates
Submitted by: EMBL European Bioinformatics Institute
Study: Multiazole resistance in clinical and environmental fungal isolates
show Abstracthide Abstract
Whole genome sequencing of SYBARIS Aspergillus spp. known to be multi-drug resistant and difficult to treat. Aim of this eaperiment is to investigate the genetic basis of susceptibility to disease and elucidate molecular mechanisms of drug resistance in these strains.
Library:
Name: JN10
Instrument: Illumina HiSeq 2000
Strategy: WGS
Source: GENOMIC
Selection: PCR
Layout: PAIRED
Construction protocol: Genomic DNA was extracted using the CTAB genomic DNA extraction method. Libraries were constructed using Illumina TruSeq DNA Sample Prep standard protocol. Briefly, 5 ug of high molecular weight genomic DNA (gDNA) was fragmented by Covaris sonication device. Following sonication, DNA fragments were end-repaired and A-tailed. Adapters were then ligated via a 3' thymine overhang. Finally, ligated fragments were amplified by PCR (10 cycles). Insert sizes were 400-500 bp as evaluated in an Agilent DNA 1000 Analyzer Chip.
Experiment attributes: (show all 4 attributes...) (hide...)
Experimental Factor: strain: JN10
Experimental Factor: clinical history: environmental sample
Experimental Factor: pathogenicity: environmental
Experimental Factor: overall azole resistance: azole-sensitive
Run# of Spots# of BasesSizePublished
ERR232424unavailable2016-05-01

ID:
2492198

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