2XM8: Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2

PDB ID: 2XM8Download
MMDB ID: 87775
PDB Deposition Date: 2010/7/26
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 2XM8: dimeric; determined by author and by software (PISA)
Molecular Components in 2XM8
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase Chk2
(Gene symbol: CHEK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303