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Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor)[ONCOPROTEIN/INHIBITOR]
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
Crystal structure of human WDR5 in complex with compound 19[DNA BINDING PROTEIN]
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization[Transcription/Transcription Inhibitor]
Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02[TRANSFERASE/DNA BINDING PROTEIN/DNA]
View in iCn3D Similar StructuresPubMedProteins
Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01[TRANSFERASE/DNA BINDING PROTEIN/DNA]
Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05)[TRANSFERASE/STRUCTURAL PROTEIN/DNA]
View in iCn3D Similar StructuresPubMedProteinsConserved Domains
Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02)[TRANSFERASE/STRUCTURAL PROTEIN/DNA]
Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01)[TRANSFERASE/STRUCTURAL PROTEIN/DNA]
Crystal structure of WDR5 in complex with the WIN peptide of PDPK1[TRANSCRIPTION]
View in iCn3D Similar StructuresProteinsConserved Domains
Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction[TRANSCRIPTION]
Crystal structure of human WDR5 in complex with monomethyl H3R2 peptide[GENE REGULATION]
Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine[GENE REGULATION]
Crystal structure of human WDR5 in complex with monomethyl L-arginine[GENE REGULATION]
Crystal structure of human WDR5 in complex with L-arginine[GENE REGULATION]
Crystal structure of human WDR5[GENE REGULATION]
Discovery and Structure-Based optimization of potent and selective WDR5 inhibitors containing a dihydroisoquinolinone bicyclic core[TRANSCRIPTION]
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome[HISTONE BINDING/DNA BINDING/DNA]
Cryo-EM structure of MLL1 core complex bound to the nucleosome[HISTONE BINDING/DNA BINDING/DNA]
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