4WTI: CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-ACGG, RNA PRIMER 5'-PCC, MN2+, AND GDP

PDB ID: 4WTIDownload
MMDB ID: 126956
PDB Deposition Date: 2014/10/30
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Hepatitis C virus JFH-1▼
Similar Structures:
Biological Unit for 4WTI: trimeric; determined by author
Molecular Components in 4WTI
Label Count Molecule
Protein (1 molecule)
1
RNA-directed RNA Polymerase
Molecule annotation
Nucleotides(2 molecules)
1
RNA Template Acgg
Molecule annotation
1
RNA Primer CC
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
3
MANGANESE (II) IONMANGANESE (II) ION
2
1
CHLORIDE IONCHLORIDE ION
3
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
4
1
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303