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Terb1 telomere repeat binding bouquet formation protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307615, updated on 9-Dec-2024

Summary

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Official Symbol
Terb1provided by RGD
Official Full Name
telomere repeat binding bouquet formation protein 1provided by RGD
Primary source
RGD:1310400
See related
EnsemblRapid:ENSRNOG00000055097 AllianceGenome:RGD:1310400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc79; RGD1310400
Summary
Predicted to be involved in meiotic telomere clustering. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination; homologous chromosome pairing at meiosis; and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region and nuclear inner membrane. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in spermatogenic failure 60. Orthologous to human TERB1 (telomere repeat binding bouquet formation protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 50.1), Kidney (RPKM 10.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Terb1 in Genome Data Viewer
Location:
19p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (480160..534534)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (473720..528069)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (682013..736358)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 7 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein. Daniel K, et al. BMC Cell Biol, 2014 May 22. PMID 24885367, Free PMC Article
  2. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Shibuya H, et al. Cell, 2015 Nov 19. PMID 26548954
  3. The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. Shibuya H, et al. Nat Cell Biol, 2014 Feb. PMID 24413433
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic attachment of telomere to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of shelterin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
telomere repeat binding bouquet formation protein 1; telomere repeats-binding bouquet formation protein 1
Names
coiled-coil domain containing 79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431307.1 → NP_001418236.1  telomere repeat binding bouquet formation protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

  2. NM_001431308.1 → NP_001418237.1  telomere repeat binding bouquet formation protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

  3. NM_001431309.1 → NP_001418238.1  telomere repeat binding bouquet formation protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

  4. NM_001431310.1 → NP_001418239.1  telomere repeat binding bouquet formation protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

  5. NM_001431311.1 → NP_001418240.1  telomere repeat binding bouquet formation protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

  6. NM_001431312.1 → NP_001418241.1  telomere repeat binding bouquet formation protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2KAQ9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    480160..534534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772251.4 → XP_008770473.1  telomere repeats-binding bouquet formation protein 1 isoform X1

    Related
    ENSRNOP00000075491.2, ENSRNOT00000087469.3
    Conserved Domains (1) summary
    cd11658
    Location:715 → 760
    SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like

  2. XM_063278878.1 → XP_063134948.1  telomere repeats-binding bouquet formation protein 1 isoform X3

    Related
    ENSRNOP00000110188.1, ENSRNOT00000150865.1

  3. XM_063278877.1 → XP_063134947.1  telomere repeats-binding bouquet formation protein 1 isoform X2

  4. XM_008772252.4 → XP_008770474.1  telomere repeats-binding bouquet formation protein 1 isoform X2

    Conserved Domains (3) summary
    smart00717
    Location:711 → 760
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11658
    Location:714 → 759
    SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
    cd00020
    Location:16 → 88
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

  5. XM_008772255.4 → XP_008770477.1  telomere repeats-binding bouquet formation protein 1 isoform X4

    See identical proteins and their annotated locations for XP_008770477.1

    UniProtKB/TrEMBL
    A0A0G2KAQ9
    Conserved Domains (3) summary
    smart00717
    Location:661 → 710
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11658
    Location:664 → 709
    SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
    cd00020
    Location:16 → 88
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

  6. XM_008772256.4 → XP_008770478.1  telomere repeats-binding bouquet formation protein 1 isoform X5

    See identical proteins and their annotated locations for XP_008770478.1

    UniProtKB/TrEMBL
    A0A0G2KAQ9
    Conserved Domains (3) summary
    smart00717
    Location:660 → 709
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11658
    Location:663 → 708
    SANT_DMAP1_like; SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like
    cd00020
    Location:16 → 88
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

  7. XM_063278879.1 → XP_063134949.1  telomere repeats-binding bouquet formation protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2KAQ9

  8. XM_039098321.2 → XP_038954249.1  telomere repeats-binding bouquet formation protein 1 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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