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Klra2 killer cell lectin-like receptor, subfamily A, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494194, updated on 4-Jan-2025

Summary

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Official Symbol
Klra2provided by RGD
Official Full Name
killer cell lectin-like receptor, subfamily A, member 2provided by RGD
Primary source
RGD:1359667
See related
EnsemblRapid:ENSRNOG00000031515 AllianceGenome:RGD:1359667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Klra1; Ly49i8
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 99.6), Kidney (RPKM 20.2) and 7 other tissues See more
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Genomic context

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See Klra2 in Genome Data Viewer
Location:
4q42
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166604723..166717294, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164873735..164985429, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165426365..165460140, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 stimulatory receptor 7 Neighboring gene killer cell lectin-like receptor, subfamily A, member 5 Neighboring gene Ly49 inhibitory receptor 7 Neighboring gene uncharacterized LOC108350878 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mago homolog B, exon junction complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. Nylenna O, et al. Eur J Immunol, 2005 Jan. PMID 15593300
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
killer cell lectin-like receptor 2
Names
Ly49 inhibitory receptor 8
killer cell lectin-like receptor, subfamily A, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009486.2 → NP_001009486.1  killer cell lectin-like receptor 2

    See identical proteins and their annotated locations for NP_001009486.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8
    Related
    ENSRNOP00000108955.1, ENSRNOT00000163444.1
    Conserved Domains (2) summary
    cd03593
    Location:154 → 268
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    166604723..166717294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108019.2 → XP_038963947.1  killer cell lectin-like receptor 2 isoform X5

    Conserved Domains (2) summary
    cd03593
    Location:154 → 229
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  2. XM_063286439.1 → XP_063142509.1  killer cell lectin-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8

  3. XM_063286440.1 → XP_063142510.1  killer cell lectin-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8

  4. XM_039108018.2 → XP_038963946.1  killer cell lectin-like receptor 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91
    Conserved Domains (2) summary
    cd03593
    Location:154 → 244
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  5. XM_039108017.2 → XP_038963945.1  killer cell lectin-like receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, F7EU37
    Related
    ENSRNOP00000081950.2, ENSRNOT00000106632.2
    Conserved Domains (2) summary
    cd03593
    Location:154 → 268
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  6. XM_039108014.2 → XP_038963942.1  killer cell lectin-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8
    Conserved Domains (2) summary
    cd03593
    Location:154 → 268
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  7. XM_008763404.4 → XP_008761626.1  killer cell lectin-like receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JYA0, A0A8I6A542, A6IM91
    Related
    ENSRNOP00000087932.2, ENSRNOT00000096273.2
    Conserved Domains (2) summary
    cd03593
    Location:124 → 238
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:46 → 137
    Ly49; Ly49-like protein, N-terminal region

  8. XM_039108015.2 → XP_038963943.1  killer cell lectin-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8
    Conserved Domains (2) summary
    cd03593
    Location:154 → 268
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  9. XM_039108016.2 → XP_038963944.1  killer cell lectin-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYA0, A6IM91, Q5MPW8
    Related
    ENSRNOP00000070575.2, ENSRNOT00000082207.3
    Conserved Domains (2) summary
    cd03593
    Location:154 → 268
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:48 → 167
    Ly49; Ly49-like protein, N-terminal region

  10. XM_039108021.2 → XP_038963949.1  killer cell lectin-like receptor 2 isoform X6

    Conserved Domains (1) summary
    pfam08391
    Location:48 → 149
    Ly49; Ly49-like protein, N-terminal region

  11. XM_039108022.2 → XP_038963950.1  killer cell lectin-like receptor 2 isoform X7

    Conserved Domains (1) summary
    pfam08391
    Location:48 → 149
    Ly49; Ly49-like protein, N-terminal region

RNA

  1. XR_010065684.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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