Gfral GDNF family receptor alpha like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gfralprovided by RGD
Official Full Name: GDNF family receptor alpha likeprovided by RGD
Primary source: RGD:1565220
See related: EnsemblRapid:ENSRNOG00000032063 AllianceGenome:RGD:1565220
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565220
Summary: Predicted to enable glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 6.0) and Adrenal (RPKM 1.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85798337..85843705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76917894..76963258, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (83235647..83282635, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute Activation of GFRAL in the Area Postrema Contributes to Glucose Regulation Independent of Weight.
Title: Acute Activation of GFRAL in the Area Postrema Contributes to Glucose Regulation Independent of Weight.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables glial cell-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables glial cell-derived neurotrophic factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GDF15-GFRAL signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in GDF15-GFRAL signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in GDF15-GFRAL signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of appetite	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to metformin	IEA Inferred from Electronic Annotation more info
involved_in response to metformin	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GDNF family receptor alpha-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191998.2 → NP_001178927.1 GDNF family receptor alpha-like isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

D3ZB94

UniProtKB/TrEMBL

A0A8L2QLI8

Related

ENSRNOP00000103254.1, ENSRNOT00000127264.1

Conserved Domains (1) summary

pfam02351
Location:132 → 211

GDNF; GDNF/GAS1 domain
NM_001401789.1 → NP_001388718.1 GDNF family receptor alpha-like isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000104972.1, ENSRNOT00000166517.1
NM_001401790.1 → NP_001388719.1 GDNF family receptor alpha-like isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000112426.1, ENSRNOT00000146996.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

85798337..85843705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081963.2 → XP_038937891.1 GDNF family receptor alpha-like isoform X1

Conserved Domains (1) summary

pfam02351
Location:251 → 330

GDNF; GDNF/GAS1 domain