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    Zfp608 zinc finger protein 608 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp608provided by RGD
    Official Full Name
    zinc finger protein 608provided by RGD
    Primary source
    RGD:1306824
    See related
    EnsemblRapid:ENSRNOG00000023197 AllianceGenome:RGD:1306824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf608
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF608 (zinc finger protein 608). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 145.5), Heart (RPKM 64.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp608 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (50503043..50611019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (48304873..48412846, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (49829650..49937522, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556109 Neighboring gene ribosomal protein L15 like 3 Neighboring gene uncharacterized LOC108348794 Neighboring gene uncharacterized LOC134483025 Neighboring gene uncharacterized LOC102556416

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-518c-3p alleviates endometriosis by inhibiting ectopic endometrial migration and epithelial-mesenchymal transition via targeting ZNF608. Lu B, et al. Arch Gynecol Obstet, 2023 Jan. PMID 35275273
    2. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Reed NP, et al. Genes Immun, 2013 Jan. PMID 23076336, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-518c-3p alleviates endometriosis by inhibiting ectopic endometrial migration and epithelial-mesenchymal transition via targeting ZNF608.
      Title: MiR-518c-3p alleviates endometriosis by inhibiting ectopic endometrial migration and epithelial-mesenchymal transition via targeting ZNF608.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 608

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107378.2 → NP_001100848.2  zinc finger protein 608

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IX44, D3ZNA1
      Related
      ENSRNOP00000034061.6, ENSRNOT00000033254.7
      Conserved Domains (2) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1102 → 1320
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      50503043..50611019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096782.2 → XP_038952710.1  zinc finger protein 608 isoform X1

      UniProtKB/TrEMBL
      A6IX44, D3ZNA1
      Conserved Domains (2) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1102 → 1320
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. XM_039096785.2 → XP_038952713.1  zinc finger protein 608 isoform X3

      UniProtKB/TrEMBL
      A6IX46
      Conserved Domains (2) summary
      COG5189
      Location:215 → 296
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:806 → 1024
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    3. XM_039096784.2 → XP_038952712.1  zinc finger protein 608 isoform X2

      UniProtKB/TrEMBL
      A6IX46
      Conserved Domains (2) summary
      COG5189
      Location:229 → 310
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:820 → 1038
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    4. XM_063277300.1 → XP_063133370.1  zinc finger protein 608 isoform X5

      UniProtKB/TrEMBL
      A6IX46

    5. XM_039096786.2 → XP_038952714.1  zinc finger protein 608 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AIC4
      Conserved Domains (1) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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