Erc1 ELKS/RAB6-interacting/CAST family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Erc1provided by RGD
Official Full Name: ELKS/RAB6-interacting/CAST family member 1provided by RGD
Primary source: RGD:628733
See related: EnsemblRapid:ENSRNOG00000009264 AllianceGenome:RGD:628733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ERC; CAST; Elks; Cast2; ERC1b; Rab6ip2
Summary: Enables PDZ domain binding activity. Predicted to be involved in several processes, including I-kappaB phosphorylation; maintenance of presynaptic active zone structure; and positive regulation of NF-kappaB transcription factor activity. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 86.7), Heart (RPKM 84.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (154435936..154727987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (152763664..153055724, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (152087393..152380023, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
ELKS positively regulates exocytotic release in RBL-2H3 by acting on the plasma membrane upon stimulation.
Title: Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells.
new component of the cytomatrix at the active zone (CAZ) and, together with CAST1, may be involved in the formation of the CAZ structure [CAST2]
Title: CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.
ELKS is involved in Ca(2+)-dependent exocytosis from PC12 cells
Title: ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells.
characterized a family of active zone proteins whose binding to RIMs, presynaptic active zone proteins that regulate neurotransmitter release, is regulated by tissue-specific alternative splicing
Title: A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE095665 (e-PCR)
- UniSTS:243492

d4rat107 (e-PCR)
- UniSTS:121940

BE108954 (e-PCR)
- UniSTS:247929

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of presynaptic active zone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of presynaptic active zone structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of IkappaB kinase complex	IEA Inferred from Electronic Annotation more info
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ELKS/Rab6-interacting/CAST family member 1

Names: CAZ-associated structural protein 2; ERC protein 1; ERC-1; RIM-Binding Protein; Rab6-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394882.1 → NP_001381811.1 ELKS/Rab6-interacting/CAST family member 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GKZ4, F1LPE9

Related

ENSRNOP00000094050.1, ENSRNOT00000109038.2

Conserved Domains (2) summary

pfam09457
Location:1072 → 1112

RBD-FIP; FIP domain

pfam10174
Location:155 → 986

Cast; RIM-binding protein of the cytomatrix active zone
NM_001394883.1 → NP_001381812.1 ELKS/Rab6-interacting/CAST family member 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JYT1, F1LPE9

Conserved Domains (2) summary

pfam09457
Location:1068 → 1108

RBD-FIP; FIP domain

pfam10174
Location:155 → 982

Cast; RIM-binding protein of the cytomatrix active zone
NM_001394884.1 → NP_001381813.1 ELKS/Rab6-interacting/CAST family member 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6A0L5, A6IL87, F1LPE9

Related

ENSRNOP00000084657.2, ENSRNOT00000115061.2

Conserved Domains (2) summary

pfam09457
Location:1040 → 1080

RBD-FIP; FIP domain

pfam10174
Location:155 → 954

Cast; RIM-binding protein of the cytomatrix active zone

RNA

NR_172210.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

154435936..154727987 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237230.4 → XP_006237292.1 ELKS/Rab6-interacting/CAST family member 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AIL7

Conserved Domains (4) summary

pfam09457
Location:996 → 1036

RBD-FIP; FIP domain

pfam10174
Location:155 → 910

Cast; RIM-binding protein of the cytomatrix active zone

pfam16046
Location:732 → 880

FAM76; FAM76 protein

cl21478
Location:846 → 917

ATP-synt_B; ATP synthase B/B' CF(0)
XM_063285644.1 → XP_063141714.1 ELKS/Rab6-interacting/CAST family member 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AIL7

Related

ENSRNOP00000092904.2, ENSRNOT00000102886.2
XM_039107148.2 → XP_038963076.1 ELKS/Rab6-interacting/CAST family member 1 isoform X1

UniProtKB/TrEMBL

F1LPE9

Related

ENSRNOP00000070778.3, ENSRNOT00000091473.3

Conserved Domains (2) summary

pfam09457
Location:1071 → 1111

RBD-FIP; FIP domain

pfam10174
Location:155 → 985

Cast; RIM-binding protein of the cytomatrix active zone
XM_063285649.1 → XP_063141719.1 ELKS/Rab6-interacting/CAST family member 1 isoform X8

UniProtKB/TrEMBL

A0A8I6AIL7, A6IL88
XM_063285647.1 → XP_063141717.1 ELKS/Rab6-interacting/CAST family member 1 isoform X6

UniProtKB/TrEMBL

F1LPE9
XM_063285648.1 → XP_063141718.1 ELKS/Rab6-interacting/CAST family member 1 isoform X7

UniProtKB/TrEMBL

A0A8I6AIL7, A6IL89
XM_063285646.1 → XP_063141716.1 ELKS/Rab6-interacting/CAST family member 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AIL7
XM_063285645.1 → XP_063141715.1 ELKS/Rab6-interacting/CAST family member 1 isoform X4

UniProtKB/TrEMBL

F1LPE9

Related

ENSRNOP00000012397.5, ENSRNOT00000012397.6