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    Ces2j carboxylesterase 2J [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ces2jprovided by RGD
    Official Full Name
    carboxylesterase 2Jprovided by RGD
    Primary source
    RGD:1591368
    See related
    EnsemblRapid:ENSRNOG00000029744 AllianceGenome:RGD:1591368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 349.5) See more
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    Genomic context

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    See Ces2j in Genome Data Viewer
    Location:
    19p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (286461..312887)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (280009..306152)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (487723..495140)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098497 Neighboring gene discs large MAGUK scaffold protein 5 like 13 Neighboring gene disks large homolog 5-like Neighboring gene mediator complex subunit 29, pseudogene 1 Neighboring gene cytosolic iron-sulfur assembly component 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 2J
    Names
    carboxylesterase 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190380.1 → NP_001177309.1  carboxylesterase 2J precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8L2Q7A9, A6JXT6, D3ZP14
      Related
      ENSRNOP00000058447.4, ENSRNOT00000061734.5
      Conserved Domains (2) summary
      COG0657
      Location:70 → 228
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:30 → 535
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      286461..312887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097983.2 → XP_038953911.1  carboxylesterase 2J isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q7A9, A6JXT6
      Conserved Domains (1) summary
      pfam00135
      Location:50 → 555
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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