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    Daam2 dishevelled associated activator of morphogenesis 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316201, updated on 9-Dec-2024

    Summary

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    Symbol
    Daam2provided by RGD
    Full Name
    dishevelled associated activator of morphogenesis 2provided by RGD
    Primary source
    RGD:1306128
    See related
    EnsemblRapid:ENSRNOG00000053945 AllianceGenome:RGD:1306128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of oligodendrocyte differentiation; podocyte cell migration; and regulation of Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 91.3), Testes (RPKM 73.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Daam2 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (18926620..19044672)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (11428913..11546982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (13444883..13493154)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 16, pseudogene 1 Neighboring gene kinesin family member 6 Neighboring gene uncharacterized LOC134480334 Neighboring gene uncharacterized LOC134480336 Neighboring gene uncharacterized LOC120094630 Neighboring gene molybdenum cofactor synthesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells. Xu J, et al. Mol Cell Endocrinol, 2023 Mar 1. PMID 36681175
    2. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Lee HK, et al. Dev Cell, 2012 Jan 17. PMID 22227309, Free PMC Article
    3. Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Welsh IC, et al. Dev Cell, 2013 Sep 30. PMID 24091014, Free PMC Article
    4. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Lee HK, et al. Neuron, 2015 Mar 18. PMID 25754822, Free PMC Article
    5. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells.
      Title: Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dorsal spinal cord development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disheveled-associated activator of morphogenesis 2
    Names
    disheveled-associated activator of morphogenesis 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427649.1 → NP_001414578.1  disheveled-associated activator of morphogenesis 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K988, A0A8I6B158
      Related
      ENSRNOP00000094568.1, ENSRNOT00000103217.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      18926620..19044672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084447.2 → XP_038940375.1  disheveled-associated activator of morphogenesis 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K988
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1008
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_063267081.1 → XP_063123151.1  disheveled-associated activator of morphogenesis 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K988

    3. XM_039084452.2 → XP_038940380.1  disheveled-associated activator of morphogenesis 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K988
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1001
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. XM_039084455.2 → XP_038940383.1  disheveled-associated activator of morphogenesis 2 isoform X5

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587 → 643
      FH2; Formin Homology 2 Domain

    5. XM_039084450.2 → XP_038940378.1  disheveled-associated activator of morphogenesis 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K988
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1008
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_039084449.2 → XP_038940377.1  disheveled-associated activator of morphogenesis 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K988
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1008
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_039084451.2 → XP_038940379.1  disheveled-associated activator of morphogenesis 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K988
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1008
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    8. XM_039084448.2 → XP_038940376.1  disheveled-associated activator of morphogenesis 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K988
      Related
      ENSRNOP00000074902.2, ENSRNOT00000088651.3
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 1008
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    9. XM_063267082.1 → XP_063123152.1  disheveled-associated activator of morphogenesis 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K988, A0A8I6B158

    RNA

    1. XR_010054590.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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