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    Mcmdc2 minichromosome maintenance domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcmdc2provided by RGD
    Official Full Name
    minichromosome maintenance domain containing 2provided by RGD
    Primary source
    RGD:1561068
    See related
    EnsemblRapid:ENSRNOG00000021702 AllianceGenome:RGD:1561068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within meiosis I cell cycle process; oogenesis; and spermatogenesis. Predicted to be active in nucleus. Orthologous to human MCMDC2 (minichromosome maintenance domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 24.6), Thymus (RPKM 14.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcmdc2 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14071609..14120435, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9291967..9337526, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8973861..9039616, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene uncharacterized LOC102556004 Neighboring gene transcription factor 24 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene serum/glucocorticoid regulated kinase family, member 3 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. Finsterbusch F, et al. PLoS Genet, 2016 Oct. PMID 27760146, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within late meiotic recombination nodule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic recombination nodule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    minichromosome maintenance domain-containing protein 2
    Names
    MCM domain-containing protein 2
    MCM domain-containing protein C8orf45 homolog
    uncharacterized protein C8orf45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024340.1 → NP_001019511.2  minichromosome maintenance domain-containing protein 2

      See identical proteins and their annotated locations for NP_001019511.2

      Status: VALIDATED

      Source sequence(s)
      BC083882
      UniProtKB/Swiss-Prot
      Q5XI14
      Related
      ENSRNOP00000037494.7, ENSRNOT00000030053.6
      Conserved Domains (2) summary
      cl28901
      Location:398 → 624
      MCM; MCM helicase family
      pfam17855
      Location:541 → 625
      MCM_lid; MCM AAA-lid domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14071609..14120435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288171.1 → XP_063144241.1  minichromosome maintenance domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A6JFF7

    2. XM_006237787.5 → XP_006237849.1  minichromosome maintenance domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A6JFF7

    3. XM_063288170.1 → XP_063144240.1  minichromosome maintenance domain-containing protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5XI14

    4. XM_039110522.2 → XP_038966450.1  minichromosome maintenance domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5XI14
      Conserved Domains (2) summary
      cl28901
      Location:398 → 624
      MCM; MCM helicase family
      pfam17855
      Location:541 → 625
      MCM_lid; MCM AAA-lid domain

    5. XM_006237782.5 → XP_006237844.1  minichromosome maintenance domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237844.1

      UniProtKB/Swiss-Prot
      Q5XI14
      UniProtKB/TrEMBL
      R9PXX4
      Conserved Domains (1) summary
      pfam00493
      Location:389 → 630
      MCM; MCM2/3/5 family

    6. XM_006237784.5 → XP_006237846.1  minichromosome maintenance domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006237846.1

      UniProtKB/Swiss-Prot
      Q5XI14
      Conserved Domains (2) summary
      cl28901
      Location:398 → 624
      MCM; MCM helicase family
      pfam17855
      Location:541 → 625
      MCM_lid; MCM AAA-lid domain

    7. XM_039110523.2 → XP_038966451.1  minichromosome maintenance domain-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      Q5XI14
      Conserved Domains (2) summary
      cl28901
      Location:361 → 587
      MCM; MCM helicase family
      pfam17855
      Location:504 → 588
      MCM_lid; MCM AAA-lid domain

    8. XM_006237785.5 → XP_006237847.1  minichromosome maintenance domain-containing protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5XI14
      Conserved Domains (1) summary
      pfam00493
      Location:384 → 625
      MCM; MCM2/3/5 family

    9. XM_006237788.5 → XP_006237850.1  minichromosome maintenance domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A6JFF7

    10. XM_006237781.5 → XP_006237843.1  minichromosome maintenance domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237843.1

      UniProtKB/Swiss-Prot
      Q5XI14
      UniProtKB/TrEMBL
      R9PXX4
      Related
      ENSRNOP00000112584.1, ENSRNOT00000155481.1
      Conserved Domains (1) summary
      pfam00493
      Location:389 → 630
      MCM; MCM2/3/5 family

    11. XM_063288175.1 → XP_063144245.1  minichromosome maintenance domain-containing protein 2 isoform X13

    12. XM_063288174.1 → XP_063144244.1  minichromosome maintenance domain-containing protein 2 isoform X12

    13. XM_039110524.2 → XP_038966452.1  minichromosome maintenance domain-containing protein 2 isoform X11

      Conserved Domains (2) summary
      cl28901
      Location:216 → 442
      MCM; MCM helicase family
      pfam17855
      Location:359 → 443
      MCM_lid; MCM AAA-lid domain

    14. XM_063288173.1 → XP_063144243.1  minichromosome maintenance domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A6JFF7

    15. XM_006237789.5 → XP_006237851.1  minichromosome maintenance domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A6JFF7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI14.1 GenPept UniProtKB/Swiss-Prot:Q5XI14

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