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    Mug2 murinoglobulin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408236, updated on 9-Dec-2024

    Summary

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    Symbol
    Mug2provided by RGD
    Full Name
    murinoglobulin 2provided by RGD
    Primary source
    RGD:1302962
    See related
    EnsemblRapid:ENSRNOG00000075610 AllianceGenome:RGD:1302962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 8. Orthologous to several human genes including PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 5552.5) See more
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    Genomic context

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    See Mug2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156836140..156908972)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155164061..155236894)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154215262..154282608)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene murinoglobulin 1 Neighboring gene uncharacterized LOC108350756 Neighboring gene C3 and PZP-like, alpha-2-macroglobulin domain containing 8 Neighboring gene thymosin beta-10-like Neighboring gene uncharacterized LOC134486841

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and negative transcriptional regulation by glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene. Northemann W, et al. Biochemistry, 1989 Jan 10. PMID 2495816
    2. Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. Enghild JJ, et al. J Biol Chem, 1989 Jul 5. PMID 2472396
    3. Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis. Cheong SS, et al. Am J Hum Genet, 2016 Dec 1. PMID 27839872, Free PMC Article
    4. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
    5. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, et al. Eur J Biochem, 1987 Apr 15. PMID 2436907

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    murinoglobulin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395728.1 → NP_001382657.1  murinoglobulin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AQK4
      Related
      ENSRNOP00000093643.2, ENSRNOT00000119571.2
      Conserved Domains (3) summary
      COG2373
      Location:760 → 1089
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:974 → 1280
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      cl23771
      Location:365 → 414
      Big_1; Bacterial Ig-like domain (group 1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156836140..156908972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107979.2 → XP_038963907.1  murinoglobulin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQK4
      Related
      ENSRNOP00000091322.1, ENSRNOT00000119344.2
      Conserved Domains (7) summary
      cd02897
      Location:974 → 1280
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:754 → 844
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1392 → 1479
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:457 → 605
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3

    2. XM_039107980.2 → XP_038963908.1  murinoglobulin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQK4
      Conserved Domains (7) summary
      cd02897
      Location:903 → 1209
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:683 → 773
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1321 → 1408
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:386 → 534
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:277 → 372
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:152 → 238
      MG3; Macroglobulin domain MG3
      cl19929
      Location:94 → 150
      A2M_N; MG2 domain

    3. XM_063286427.1 → XP_063142497.1  murinoglobulin-2 isoform X3

    4. XM_063286428.1 → XP_063142498.1  murinoglobulin-2 isoform X4

      UniProtKB/TrEMBL
      A6ILD5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002826.1: Suppressed sequence

      Description
      NM_001002826.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE52.1 GenPept UniProtKB/Swiss-Prot:Q6IE52

    Gene LinkOut

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