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    Lrrc61 leucine rich repeat containing 61 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc61provided by RGD
    Official Full Name
    leucine rich repeat containing 61provided by RGD
    Primary source
    RGD:1561800
    See related
    EnsemblRapid:ENSRNOG00000008234 AllianceGenome:RGD:1561800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561800
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Orthologous to human LRRC61 (leucine rich repeat containing 61). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 399.0), Lung (RPKM 58.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc61 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78834783..78854810)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77503882..77523909)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78186181..78206818)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862 Neighboring gene ATPase, H+ transporting V0 subunit e2 Neighboring gene retinoic acid receptor responder 2 Neighboring gene hypothetical LOC100363281 Neighboring gene replication initiator 1 Neighboring gene zinc finger protein 775

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109231.2 → NP_001102701.1  leucine-rich repeat-containing protein 61

      See identical proteins and their annotated locations for NP_001102701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. NM_001395079.1 → NP_001382008.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Related
      ENSRNOP00000083792.1, ENSRNOT00000097373.2
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78834783..78854810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236437.5 → XP_006236499.1  leucine-rich repeat-containing protein 61 isoform X1

      See identical proteins and their annotated locations for XP_006236499.1

      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Related
      ENSRNOP00000010864.3, ENSRNOT00000010864.6
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039108124.1 → XP_038964052.1  leucine-rich repeat-containing protein 61 isoform X1

      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Related
      ENSRNOP00000092465.1, ENSRNOT00000115463.2
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_006236436.3 → XP_006236498.1  leucine-rich repeat-containing protein 61 isoform X1

      See identical proteins and their annotated locations for XP_006236498.1

      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Related
      ENSRNOP00000100457.1, ENSRNOT00000144264.1
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_039108125.2 → XP_038964053.1  leucine-rich repeat-containing protein 61 isoform X1

      UniProtKB/TrEMBL
      A6K0F7, D3ZA60
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:49 → 166
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version

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