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    Klf12 KLF transcription factor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306110, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Klf12provided by RGD
    Official Full Name
    KLF transcription factor 12provided by RGD
    Primary source
    RGD:1309204
    See related
    EnsemblRapid:ENSRNOG00000009145 AllianceGenome:RGD:1309204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Orthologous to human KLF12 (KLF transcription factor 12). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 108.1), Kidney (RPKM 56.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klf12 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (83037548..83469998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (76628778..77062000, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (84316986..84748549, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097060 Neighboring gene uncharacterized LOC102553927 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC103693766 Neighboring gene uncharacterized LOC134482159 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Suda S, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16615998
    2. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Imhof A, et al. Mol Cell Biol, 1999 Jan. PMID 9858544, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 12
    Names
    Kruppel-like factor 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107281.1 → NP_001100751.1  Krueppel-like factor 12

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HU64, D3ZG44
      Related
      ENSRNOP00000012424.8, ENSRNOT00000012424.9
      Conserved Domains (3) summary
      COG5048
      Location:242 → 418
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      83037548..83469998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093393.2 → XP_038949321.1  Krueppel-like factor 12 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMS3, D3ZG44
      Related
      ENSRNOP00000109858.1, ENSRNOT00000162907.1
      Conserved Domains (4) summary
      COG5048
      Location:195 → 371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:333 → 358
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:12 → 194
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    2. XM_039093390.2 → XP_038949318.1  Krueppel-like factor 12 isoform X6

      UniProtKB/TrEMBL
      D3ZG44
      Conserved Domains (4) summary
      COG5048
      Location:206 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 322
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:8 → 205
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    3. XM_006252410.5 → XP_006252472.1  Krueppel-like factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K610, A6HU63, D3ZG44
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    4. XM_039093395.1 → XP_038949323.1  Krueppel-like factor 12 isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    5. XM_017599716.2 → XP_017455205.1  Krueppel-like factor 12 isoform X6

      UniProtKB/TrEMBL
      D3ZG44
      Conserved Domains (4) summary
      COG5048
      Location:206 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 322
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:8 → 205
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    6. XM_017599718.2 → XP_017455207.1  Krueppel-like factor 12 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMS3, D3ZG44
      Conserved Domains (4) summary
      COG5048
      Location:195 → 371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:333 → 358
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:12 → 194
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    7. XM_006252409.4 → XP_006252471.1  Krueppel-like factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K610, A6HU63, D3ZG44
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    8. XM_063274334.1 → XP_063130404.1  Krueppel-like factor 12 isoform X8

      Related
      ENSRNOP00000094732.2, ENSRNOT00000115385.2

    9. XM_063274333.1 → XP_063130403.1  Krueppel-like factor 12 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMS3, D3ZG44

    10. XM_039093386.1 → XP_038949314.1  Krueppel-like factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K610, A6HU63, D3ZG44
      Related
      ENSRNOP00000073633.1, ENSRNOT00000090009.3
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    11. XM_063274331.1 → XP_063130401.1  Krueppel-like factor 12 isoform X6

      UniProtKB/TrEMBL
      D3ZG44

    12. XM_039093384.2 → XP_038949312.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:284 → 460
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:378 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:422 → 447
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:101 → 283
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    13. XM_039093383.2 → XP_038949311.1  Krueppel-like factor 12 isoform X3

      Related
      ENSRNOP00000099671.1, ENSRNOT00000152113.1
      Conserved Domains (4) summary
      COG5048
      Location:314 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:452 → 477
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:116 → 313
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    14. XM_039093388.2 → XP_038949316.1  Krueppel-like factor 12 isoform X6

      UniProtKB/TrEMBL
      D3ZG44
      Related
      ENSRNOP00000109863.1, ENSRNOT00000150382.1
      Conserved Domains (4) summary
      COG5048
      Location:206 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 322
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:8 → 205
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    15. XM_039093394.2 → XP_038949322.1  Krueppel-like factor 12 isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    16. XM_063274328.1 → XP_063130398.1  Krueppel-like factor 12 isoform X1

    17. XM_063274326.1 → XP_063130396.1  Krueppel-like factor 12 isoform X1

    18. XM_063274327.1 → XP_063130397.1  Krueppel-like factor 12 isoform X1

    19. XM_063274329.1 → XP_063130399.1  Krueppel-like factor 12 isoform X2

      UniProtKB/TrEMBL
      A6JPT4

    RNA

    1. XR_005493737.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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