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    Ptgfrn prostaglandin F2 receptor inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptgfrnprovided by RGD
    Official Full Name
    prostaglandin F2 receptor inhibitorprovided by RGD
    Primary source
    RGD:3437
    See related
    EnsemblRapid:ENSRNOG00000015655 AllianceGenome:RGD:3437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EWI-F; CD9P-1
    Summary
    Predicted to be involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to act upstream of or within lipid droplet organization. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human PTGFRN (prostaglandin F2 receptor inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 198.9), Adrenal (RPKM 149.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptgfrn in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (191158166..191233432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (188469521..188544795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (203423143..203494391, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18A, pseudogene 3 Neighboring gene transcription termination factor 2 Neighboring gene CD101 molecule Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene Cd2 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Eicosanoid and amino acid metabolism in transient acute psychoses with psychedelic symptoms. Fekkes D, et al. Prostaglandins Leukot Essent Fatty Acids, 1996 Apr. PMID 8804122
    2. Cloning, sequencing and proposed structure for a prostaglandin F2 alpha receptor regulatory protein. Orlicky DJ, et al. Prostaglandins Leukot Essent Fatty Acids, 1996 Oct. PMID 8951995
    3. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. Orlicky DJ, et al. Hum Genet, 1996 May. PMID 8655148
    4. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. Orlicky DJ, et al. J Lipid Res, 1998 Jun. PMID 9643346
    5. Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP). Orlicky DJ. Prostaglandins Leukot Essent Fatty Acids, 1996 Apr. PMID 8804121

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast fusion involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myoblast fusion involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast fusion involved in skeletal muscle regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin F2 receptor negative regulator
    Names
    CD9 partner 1
    glu-Trp-Ile EWI motif-containing protein F
    prostaglandin F2-alpha receptor regulatory protein
    prostaglandin F2-alpha receptor-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019243.2 → NP_062116.2  prostaglandin F2 receptor negative regulator precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q62786
      UniProtKB/TrEMBL
      F1M790
      Related
      ENSRNOP00000021162.7, ENSRNOT00000021162.8
      Conserved Domains (4) summary
      smart00406
      Location:39 → 121
      IGv; Immunoglobulin V-Type
      cd00096
      Location:157 → 159
      Ig; Ig strand A' [structural motif]
      cd00099
      Location:273 → 378
      IgV; Immunoglobulin variable domain (IgV)
      cl11960
      Location:153 → 254
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      191158166..191233432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62786.1 GenPept UniProtKB/Swiss-Prot:Q62786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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