TRIM74 tripartite motif containing 74 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM74provided by HGNC
Official Full Name: tripartite motif containing 74provided by HGNC
Primary source: HGNC:HGNC:17453
See related: Ensembl:ENSG00000155428 MIM:612550; AllianceGenome:HGNC:17453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRIM50C
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis (RPKM 13.0), bone marrow (RPKM 5.7) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 7q11.23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (72954868..72969681, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (74183097..74197887, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (72430016..72439997, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maps within the critical region of Williams-Beuren syndrome.
Title: Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:4585495 (e-PCR)
- UniSTS:25903

STS-N62712 (e-PCR)
- UniSTS:50779

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: tripartite motif-containing protein 74

Names: tripartite motif-containing 50C; tripartite motif-containing protein 50C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317815.2 → NP_001304744.1 tripartite motif-containing protein 74

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF498999, BC033871

Consensus CDS

CCDS5545.1

UniProtKB/Swiss-Prot

B7WP46, Q86UV6

UniProtKB/TrEMBL

I3L0H3

Conserved Domains (2) summary

cd00021
Location:90 → 125

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_198853.3 → NP_942150.1 tripartite motif-containing protein 74

See identical proteins and their annotated locations for NP_942150.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF498999, BC033871

Consensus CDS

CCDS5545.1

UniProtKB/Swiss-Prot

B7WP46, Q86UV6

UniProtKB/TrEMBL

I3L0H3

Related

ENSP00000285805.3, ENST00000285805.3

Conserved Domains (2) summary

cd00021
Location:90 → 125

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

72954868..72969681 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420354.1 → XP_047276310.1 tripartite motif-containing protein 74 isoform X3
XM_011516190.3 → XP_011514492.1 tripartite motif-containing protein 74 isoform X2

See identical proteins and their annotated locations for XP_011514492.1

UniProtKB/TrEMBL

J3KQW6

Conserved Domains (1) summary

cd00021
Location:36 → 71

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
XM_047420352.1 → XP_047276308.1 tripartite motif-containing protein 74 isoform X2

UniProtKB/TrEMBL

J3KQW6
XM_047420355.1 → XP_047276311.1 tripartite motif-containing protein 74 isoform X3
XM_047420353.1 → XP_047276309.1 tripartite motif-containing protein 74 isoform X2

UniProtKB/TrEMBL

J3KQW6
XM_011516187.4 → XP_011514489.1 tripartite motif-containing protein 74 isoform X4

See identical proteins and their annotated locations for XP_011514489.1

UniProtKB/Swiss-Prot

B7WP46, Q86UV6

UniProtKB/TrEMBL

I3L0H3

Conserved Domains (2) summary

cd00021
Location:90 → 125

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_047420356.1 → XP_047276312.1 tripartite motif-containing protein 74 isoform X5

UniProtKB/TrEMBL

C9JQH3
XM_047420350.1 → XP_047276306.1 tripartite motif-containing protein 74 isoform X1

UniProtKB/TrEMBL

I3L0H3
XM_011516189.3 → XP_011514491.1 tripartite motif-containing protein 74 isoform X1

See identical proteins and their annotated locations for XP_011514491.1

UniProtKB/TrEMBL

I3L0H3

Related

ENSP00000378665.1, ENST00000395244.5

Conserved Domains (2) summary

cd00021
Location:90 → 125

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

74183097..74197887 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358175.1 → XP_054214150.1 tripartite motif-containing protein 74 isoform X6

UniProtKB/TrEMBL

J3KQW6
XM_054358178.1 → XP_054214153.1 tripartite motif-containing protein 74 isoform X2

UniProtKB/TrEMBL

J3KQW6
XM_054358177.1 → XP_054214152.1 tripartite motif-containing protein 74 isoform X2

UniProtKB/TrEMBL

J3KQW6
XM_054358173.1 → XP_054214148.1 tripartite motif-containing protein 74 isoform X6

UniProtKB/TrEMBL

J3KQW6
XM_054358181.1 → XP_054214156.1 tripartite motif-containing protein 74 isoform X3
XM_054358179.1 → XP_054214154.1 tripartite motif-containing protein 74 isoform X2

UniProtKB/TrEMBL

J3KQW6
XM_054358174.1 → XP_054214149.1 tripartite motif-containing protein 74 isoform X6

UniProtKB/TrEMBL

J3KQW6
XM_054358176.1 → XP_054214151.1 tripartite motif-containing protein 74 isoform X1

UniProtKB/TrEMBL

I3L0H3
XM_054358180.1 → XP_054214155.1 tripartite motif-containing protein 74 isoform X7