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    Wsb2 WD repeat and SOCS box-containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wsb2provided by RGD
    Official Full Name
    WD repeat and SOCS box-containing 2provided by RGD
    Primary source
    RGD:1359599
    See related
    EnsemblRapid:ENSRNOG00000001135 AllianceGenome:RGD:1359599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein polyubiquitination. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 327.2), Brain (RPKM 289.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wsb2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44878483..44899474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (39217645..39238634, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44941655..44962679, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481300 Neighboring gene replication factor C subunit 5 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene uncharacterized LOC120095992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93822

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and SOCS box-containing protein 2
    Names
    WD SOCS-box protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007616.3 → NP_001007617.1  WD repeat and SOCS box-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001007617.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1N8, Q66HE3
      Related
      ENSRNOP00000097041.2, ENSRNOT00000108322.2
      Conserved Domains (3) summary
      cd00200
      Location:121 → 360
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd03733
      Location:364 → 402
      SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
      sd00039
      Location:157 → 195
      7WD40; WD40 repeat [structural motif]

    2. NM_001415754.1 → NP_001402683.1  WD repeat and SOCS box-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      44878483..44899474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271211.1 → XP_063127281.1  WD repeat and SOCS box-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8A6, A6J1N8, F7F7B9
    Nucleotide Protein Strain
    Heading Accession and Version

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