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    Klhl30 kelch-like family member 30 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl30provided by RGD
    Official Full Name
    kelch-like family member 30provided by RGD
    Primary source
    RGD:1309644
    See related
    EnsemblRapid:ENSRNOG00000020105 AllianceGenome:RGD:1309644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309644
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL30 (kelch like family member 30). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 168.1), Heart (RPKM 63.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl30 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99389982..99400295)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91942475..91952756)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98490583..98500880)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene selenocysteine lyase Neighboring gene espin-like Neighboring gene erythroferrone Neighboring gene ILK associated serine/threonine phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 30
    Names
    kelch-like 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399332.1 → NP_001386261.1  kelch-like protein 30

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JQQ8, D3ZHA2
      Related
      ENSRNOP00000027232.4, ENSRNOT00000027232.8
      Conserved Domains (4) summary
      PHA03098
      Location:29 → 494
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:319 → 364
      Kelch; KELCH repeat [structural motif]
      cd18469
      Location:128 → 231
      BACK_KLHL30; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30)
      cl38908
      Location:1 → 137
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99389982..99400295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267317.1 → XP_063123387.1  kelch-like protein 30 isoform X2

    2. XM_039084734.2 → XP_038940662.1  kelch-like protein 30 isoform X1

      UniProtKB/TrEMBL
      A6JQQ8, D3ZHA2
      Conserved Domains (4) summary
      PHA03098
      Location:29 → 494
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:319 → 364
      Kelch; KELCH repeat [structural motif]
      cd18469
      Location:128 → 231
      BACK_KLHL30; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30)
      cl38908
      Location:1 → 137
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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