Slc36a2 solute carrier family 36 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc36a2provided by RGD
Official Full Name: solute carrier family 36 member 2provided by RGD
Primary source: RGD:620492
See related: EnsemblRapid:ENSRNOG00000011892 AllianceGenome:RGD:620492
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pat2; Tramd1
Summary: Enables glycine transmembrane transporter activity and proline:proton symporter activity. Involved in amino acid transmembrane transport; regulation of amino acid transport; and regulation of proton transport. Predicted to be located in endoplasmic reticulum membrane; plasma membrane; and recycling endosome membrane. Predicted to be active in vacuolar membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC36A2 (solute carrier family 36 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 120.3), Thymus (RPKM 71.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (39778667..39806781, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39278002..39306082, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40497184..40525033, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)
Title: Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).
Subtrate specificity and functional characterization of Pat2 were studied.
Title: Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).
isolation of PAT2 from a rat lung cDNA library; PAT2 has a limited tissue distribution, higher affinity, and distinct substrate specificity compared to PAT1
Title: Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables L-tyrosine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables active monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino acid:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inorganic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proline:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables proline:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycine transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in proline transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proline transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proline transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proline transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of proline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of proton transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proton-coupled amino acid transporter 2

Names: proton/amino acid transporter 2; rPAT2; solute carrier family 36 (proton/amino acid symporter), member 2; tramdorin-1; transmembrane domain rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139339.2 → NP_647555.2 proton-coupled amino acid transporter 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q8K415

UniProtKB/TrEMBL

B2GUU7, F7FGD4

Related

ENSRNOP00000016440.4, ENSRNOT00000016440.8

Conserved Domains (1) summary

cl00456
Location:50 → 461

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

39778667..39806781 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268412.1 → XP_063124482.1 proton-coupled amino acid transporter 2 isoform X1
XM_063268413.1 → XP_063124483.1 proton-coupled amino acid transporter 2 isoform X2