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    Lgi4 leucine-rich repeat LGI family, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgi4provided by RGD
    Official Full Name
    leucine-rich repeat LGI family, member 4provided by RGD
    Primary source
    RGD:735035
    See related
    EnsemblRapid:ENSRNOG00000021087 AllianceGenome:RGD:735035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in myelination in peripheral nervous system; neuron maturation; and regulation of myelination. Predicted to act upstream of or within adult locomotory behavior; gliogenesis; and myelination. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 100.1), Heart (RPKM 27.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lgi4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95422461..95433296)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86294539..86305909)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89491588..89502939)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene uncharacterized LOC134483096 Neighboring gene hepsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss-of-Function Mutations in LGI4, a Secreted Ligand Involved in Schwann Cell Myelination, Are Responsible for Arthrogryposis Multiplex Congenita. Xue S, et al. Am J Hum Genet, 2017 Apr 6. PMID 28318499, Free PMC Article
    2. Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy. Gu W, et al. Neurogenetics, 2004 Feb. PMID 14505228
    3. The mouse mutation claw paw: forelimb deformity and delayed myelination throughout the peripheral nervous system. Henry EW, et al. J Hered, 1991 Jul-Aug. PMID 1652607
    4. The effect of the mouse mutation claw paw on myelination and nodal frequency in sciatic nerves. Koszowski AG, et al. J Neurosci, 1998 Aug 1. PMID 9671673, Free PMC Article
    5. Cell autonomy of the mouse claw paw mutation. Darbas A, et al. Dev Biol, 2004 Aug 15. PMID 15282162

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gliogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination in peripheral nervous system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat LGI family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199499.1 → NP_955793.1  leucine-rich repeat LGI family member 4 precursor

      See identical proteins and their annotated locations for NP_955793.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064659
      UniProtKB/TrEMBL
      A0A8I5ZQZ4, F7FDT1, Q6P2A4
      Related
      ENSRNOP00000028632.4, ENSRNOT00000028632.7
      Conserved Domains (5) summary
      smart00082
      Location:158 → 207
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:396 → 438
      EPTP; EPTP domain
      pfam12799
      Location:102 → 140
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:76 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95422461..95433296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266499.1 → XP_063122569.1  leucine-rich repeat LGI family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQZ4
      Related
      ENSRNOP00000109257.1, ENSRNOT00000121764.1

    2. XM_039081997.1 → XP_038937925.1  leucine-rich repeat LGI family member 4 isoform X2

      Conserved Domains (1) summary
      pfam03736
      Location:162 → 202
      EPTP; EPTP domain

    3. XM_039082002.1 → XP_038937930.1  leucine-rich repeat LGI family member 4 isoform X2

      Conserved Domains (1) summary
      pfam03736
      Location:162 → 202
      EPTP; EPTP domain
    Nucleotide Protein Strain
    Heading Accession and Version

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