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    Reps2 RALBP1 associated Eps domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Reps2provided by RGD
    Official Full Name
    RALBP1 associated Eps domain containing 2provided by RGD
    Primary source
    RGD:1561642
    See related
    EnsemblRapid:ENSRNOG00000061508 AllianceGenome:RGD:1561642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Reps2-ps1; RGD1561642
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in cytoplasm. Orthologous to human REPS2 (RALBP1 associated Eps domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 196.7), Kidney (RPKM 152.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Reps2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (35681260..35954103)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (32049455..32322317)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (33786611..34062941)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 12 Neighboring gene solute carrier family 25 member 39, pseudogene 5 Neighboring gene gamma-aminobutyric acid receptor-associated protein-like 2 pseudogene Neighboring gene similar to ferritin heavy polypeptide-like 17 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ralBP1-associated Eps domain-containing protein 2
    Names
    RALBP1 associated Eps domain containing 2, pseudogene 1
    RALBP1 associated Eps domain containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427498.1 → NP_001414427.1  ralBP1-associated Eps domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K1L4, A0A8I6AED1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      35681260..35954103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100469.2 → XP_038956397.1  ralBP1-associated Eps domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1L4, A6K2P2
      Related
      ENSRNOP00000090746.2, ENSRNOT00000112593.2
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:490 → 646
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_039100474.2 → XP_038956402.1  ralBP1-associated Eps domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Related
      ENSRNOP00000072143.3, ENSRNOT00000079365.3
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:380 → 585
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_039100476.2 → XP_038956404.1  ralBP1-associated Eps domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:380 → 584
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_063280136.1 → XP_063136206.1  ralBP1-associated Eps domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A0G2K1L4, A0A8I6G7F0
      Related
      ENSRNOP00000081016.1, ENSRNOT00000102637.2

    5. XM_063280135.1 → XP_063136205.1  ralBP1-associated Eps domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K1L4, A0A8I5ZKT6

    6. XM_063280137.1 → XP_063136207.1  ralBP1-associated Eps domain-containing protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K1L4

    7. XM_039100472.2 → XP_038956400.1  ralBP1-associated Eps domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Related
      ENSRNOP00000078390.2, ENSRNOT00000095937.2
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:472 → 628
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    8. XM_039100478.2 → XP_038956406.1  ralBP1-associated Eps domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (3) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    9. XM_039100471.2 → XP_038956399.1  ralBP1-associated Eps domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:489 → 645
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    10. XM_039100473.2 → XP_038956401.1  ralBP1-associated Eps domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (4) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      PRK14971
      Location:471 → 627
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    11. XM_039100479.2 → XP_038956407.1  ralBP1-associated Eps domain-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (3) summary
      smart00027
      Location:263 → 358
      EH; Eps15 homology domain
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    12. XM_039100475.2 → XP_038956403.1  ralBP1-associated Eps domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K1L4, A0A0G2K285
      Conserved Domains (4) summary
      smart00027
      Location:262 → 357
      EH; Eps15 homology domain
      PRK14971
      Location:379 → 584
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    13. XM_063280134.1 → XP_063136204.1  ralBP1-associated Eps domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1L4

    14. XM_039100477.2 → XP_038956405.1  ralBP1-associated Eps domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K1L4
      Conserved Domains (4) summary
      smart00027
      Location:262 → 357
      EH; Eps15 homology domain
      PRK14971
      Location:379 → 583
      PRK14971; DNA polymerase III subunit gamma/tau
      cl27812
      Location:18 → 112
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      cl08302
      Location:62 → 108
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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