Asb2 ankyrin repeat and SOCS box-containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Asb2provided by RGD
Full Name: ankyrin repeat and SOCS box-containing 2provided by RGD
Primary source: RGD:1306414
See related: EnsemblRapid:ENSRNOG00000051619 AllianceGenome:RGD:1306414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in Z disc. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 766.4), Heart (RPKM 560.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (128239550..128275833, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (122474754..122511014, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127212325..127248451, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139118 (e-PCR)
- UniSTS:221204

RH136912 (e-PCR)
- UniSTS:219001

BG375800 (e-PCR)
- UniSTS:243429

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic cell migration	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 2

Names: ASB-2; ankyrin repeat and SOCS box protein 2-like; ankyrin repeat and SOCS box-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011984.1 → NP_001011984.1 ankyrin repeat and SOCS box protein 2

See identical proteins and their annotated locations for NP_001011984.1

Status: PROVISIONAL

Source sequence(s)

BC085882

UniProtKB/Swiss-Prot

Q5U2S6

UniProtKB/TrEMBL

A6JEM4

Related

ENSRNOP00000071182.1, ENSRNOT00000085517.3

Conserved Domains (4) summary

cd00204
Location:232 → 357

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd03721
Location:590 → 634

SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...

pfam12796
Location:308 → 396

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:237 → 268

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

128239550..128275833 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112072.2 → XP_038968000.1 ankyrin repeat and SOCS box protein 2 isoform X2

Conserved Domains (3) summary

PHA03095
Location:199 → 480

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:237 → 268

ANK; ANK repeat [structural motif]

pfam12796
Location:112 → 202

Ank_2; Ankyrin repeats (3 copies)
XM_063261766.1 → XP_063117836.1 ankyrin repeat and SOCS box protein 2 isoform X1
XM_006240464.5 → XP_006240526.2 ankyrin repeat and SOCS box protein 2 isoform X3