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    Olfm4 olfactomedin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Olfm4provided by RGD
    Official Full Name
    olfactomedin 4provided by RGD
    Primary source
    RGD:1311708
    See related
    EnsemblRapid:ENSRNOG00000013280 AllianceGenome:RGD:1311708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity and structural molecule activity. Predicted to be involved in positive regulation of substrate adhesion-dependent cell spreading and signal transduction. Predicted to act upstream of or within negative regulation of canonical NF-kappaB signal transduction and negative regulation of immune response. Predicted to be located in several cellular components, including intercellular bridge; perinuclear region of cytoplasm; and specific granule. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Orthologous to human OLFM4 (olfactomedin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 59.1), Spleen (RPKM 25.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Olfm4 in Genome Data Viewer
    Location:
    15q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61790889..61838773)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (55385100..55429687)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (62384263..62429450)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352947 Neighboring gene protocadherin 8 Neighboring gene ribosomal protein L14 like 1 Neighboring gene microRNA 1297

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knockdown of OLFM4 protects cardiomyocytes from sepsis by inhibiting apoptosis and inflammatory responses. Chen H, et al. Allergol Immunopathol (Madr), 2024. PMID 39278846
    2. The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro. Welin A, et al. PLoS One, 2013. PMID 23922742, Free PMC Article
    3. The glycoprotein hGC-1 binds to cadherin and lectins. Liu W, et al. Exp Cell Res, 2006 Jun 10. PMID 16566923
    4. pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Rosenbauer F, et al. Blood, 2004 Jun 1. PMID 14962908
    5. Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Liu W, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534456, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of OLFM4 protects cardiomyocytes from sepsis by inhibiting apoptosis and inflammatory responses.
      Title: Knockdown of OLFM4 protects cardiomyocytes from sepsis by inhibiting apoptosis and inflammatory responses.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    olfactomedin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106052.1 → NP_001099522.1  olfactomedin-4 precursor

      See identical proteins and their annotated locations for NP_001099522.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HU14, D3ZMI6
      Related
      ENSRNOP00000039120.3, ENSRNOT00000047572.5
      Conserved Domains (1) summary
      pfam02191
      Location:249 → 501
      OLF; Olfactomedin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      61790889..61838773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770863.4 → XP_008769085.1  olfactomedin-4 isoform X1

      Conserved Domains (1) summary
      pfam02191
      Location:191 → 443
      OLF; Olfactomedin-like domain

    2. XM_063274167.1 → XP_063130237.1  olfactomedin-4 isoform X2

    3. XM_039093182.2 → XP_038949110.1  olfactomedin-4 isoform X3

      Conserved Domains (1) summary
      pfam02191
      Location:58 → 310
      OLF; Olfactomedin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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