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    Ap5z1 adaptor related protein complex 5 subunit zeta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 641386, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ap5z1provided by RGD
    Official Full Name
    adaptor related protein complex 5 subunit zeta 1provided by RGD
    Primary source
    RGD:1593125
    See related
    EnsemblRapid:ENSRNOG00000056768 AllianceGenome:RGD:1593125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kiaa0415
    Summary
    Predicted to be involved in double-strand break repair via homologous recombination and endosomal transport. Predicted to act upstream of or within several processes, including late endosome to Golgi transport; lysosomal protein catabolic process; and vacuole organization. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of AP-5 adaptor complex. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia and hereditary spastic paraplegia 48. Orthologous to human AP5Z1 (adaptor related protein complex 5 subunit zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 42.6), Kidney (RPKM 39.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap5z1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17207315..17222975, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (12093834..12109043, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14161998..14175997, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene Rap associating with DIL domain Neighboring gene poly(A) polymerase beta Neighboring gene forkhead box K1 Neighboring gene uncharacterized LOC120095892

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. Słabicki M, et al. PLoS Biol, 2010 Jun 29. PMID 20613862, Free PMC Article
    2. The fifth adaptor protein complex. Hirst J, et al. PLoS Biol, 2011 Oct. PMID 22022230, Free PMC Article
    3. Gene expression profiling of purified rat retinal ganglion cells. Farkas RH, et al. Invest Ophthalmol Vis Sci, 2004 Aug. PMID 15277470
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within late endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-5 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-5 complex subunit zeta-1
    Names
    adaptor-related protein complex 5, zeta 1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037220.5 → NP_001032297.5  AP-5 complex subunit zeta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2JYJ5
      Related
      ENSRNOP00000070678.2, ENSRNOT00000087860.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      17207315..17222975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089720.2 → XP_038945648.1  AP-5 complex subunit zeta-1 isoform X1

      Conserved Domains (1) summary
      pfam14764
      Location:228 → 346
      SPG48; AP-5 complex subunit, vesicle trafficking

    2. XM_039089719.2 → XP_038945647.1  AP-5 complex subunit zeta-1 isoform X1

      Conserved Domains (1) summary
      pfam14764
      Location:228 → 346
      SPG48; AP-5 complex subunit, vesicle trafficking

    RNA

    1. XR_005491669.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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