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    Stoml3 stomatin like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stoml3provided by RGD
    Official Full Name
    stomatin like 3provided by RGD
    Primary source
    RGD:1311090
    See related
    AllianceGenome:RGD:1311090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within signal transduction. Predicted to be located in cilium; membrane raft; and neuron projection. Predicted to be active in plasma membrane. Orthologous to human STOML3 (stomatin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1.5), Muscle (RPKM 0.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stoml3 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (139722970..139732675)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (137572691..137582402)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (142717281..142727026)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 1 Neighboring gene NHL repeat containing 3 Neighboring gene proline and serine rich 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene FRAS1 related extracellular matrix 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stomatin-like protein 3 modulates the responses of Aδ, but not C fiber bone afferent neurons to noxious mechanical stimulation in an animal model of acute experimental bone pain. Morgan M, et al. Mol Pain, 2023 Jan-Dec. PMID 38073226, Free PMC Article
    2. A stomatin-domain protein essential for touch sensation in the mouse. Wetzel C, et al. Nature, 2007 Jan 11. PMID 17167420
    3. Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons. Kobayakawa K, et al. J Neurosci, 2002 Jul 15. PMID 12122055, Free PMC Article
    4. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stomatin-like protein 3 modulates the responses of Adelta, but not C fiber bone afferent neurons to noxious mechanical stimulation in an animal model of acute experimental bone pain.
      Title: Stomatin-like protein 3 modulates the responses of Aδ, but not C fiber bone afferent neurons to noxious mechanical stimulation in an animal model of acute experimental bone pain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stomatin-like protein 3
    Names
    stomatin (Epb7.2)-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106431.1 → NP_001099901.1  stomatin-like protein 3

      See identical proteins and their annotated locations for NP_001099901.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474003
      UniProtKB/TrEMBL
      A6JVA3, D4A100
      Conserved Domains (1) summary
      cl19107
      Location:44 → 73
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      139722970..139732675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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