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    Cables2 Cdk5 and Abl enzyme substrate 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cables2provided by RGD
    Official Full Name
    Cdk5 and Abl enzyme substrate 2provided by RGD
    Primary source
    RGD:1310089
    See related
    EnsemblRapid:ENSRNOG00000051420 AllianceGenome:RGD:1310089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of cell cycle. Predicted to be located in membrane. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.2), Thymus (RPKM 56.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cables2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187725128..187739880, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167347527..167362274, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175630266..175644994, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 5 Neighboring gene ribosomal protein S21 Neighboring gene RBBP8 N-terminal like Neighboring gene GATA binding protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDK5 and ABL1 enzyme substrate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430472.1 → NP_001417401.1  CDK5 and ABL1 enzyme substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001430473.1 → NP_001417402.1  CDK5 and ABL1 enzyme substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A922

    3. NM_001430474.1 → NP_001417403.1  CDK5 and ABL1 enzyme substrate 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K716

    4. NM_001430475.1 → NP_001417404.1  CDK5 and ABL1 enzyme substrate 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001430476.1 → NP_001417405.1  CDK5 and ABL1 enzyme substrate 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      187725128..187739880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762589.3 → XP_008760811.1  CDK5 and ABL1 enzyme substrate 2 isoform X4

      Conserved Domains (1) summary
      cd00043
      Location:366 → 444
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. XM_008762588.3 → XP_008760810.1  CDK5 and ABL1 enzyme substrate 2 isoform X3

      Related
      ENSRNOP00000103865.1, ENSRNOT00000145979.1
      Conserved Domains (1) summary
      cd00043
      Location:342 → 420
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    3. XM_063285138.1 → XP_063141208.1  CDK5 and ABL1 enzyme substrate 2 isoform X5

      Related
      ENSRNOP00000074022.2, ENSRNOT00000084452.3

    4. XM_008762591.4 → XP_008760813.1  CDK5 and ABL1 enzyme substrate 2 isoform X6

      See identical proteins and their annotated locations for XP_008760813.1

      Conserved Domains (1) summary
      cd00043
      Location:366 → 422
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    5. XM_008762590.3 → XP_008760812.1  CDK5 and ABL1 enzyme substrate 2 isoform X6

      Conserved Domains (1) summary
      cd00043
      Location:366 → 422
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    6. XM_008762585.3 → XP_008760807.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

      Conserved Domains (1) summary
      cd00043
      Location:366 → 444
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    7. XM_063285139.1 → XP_063141209.1  CDK5 and ABL1 enzyme substrate 2 isoform X8

    8. XM_006235831.4 → XP_006235893.2  CDK5 and ABL1 enzyme substrate 2 isoform X7

      Conserved Domains (1) summary
      cd00043
      Location:363 → 419
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    9. XM_008762586.3 → XP_008760808.1  CDK5 and ABL1 enzyme substrate 2 isoform X2

      Related
      ENSRNOP00000089075.2, ENSRNOT00000109809.2
      Conserved Domains (1) summary
      cd00043
      Location:363 → 441
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein Strain
    Heading Accession and Version

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