Ccne1 cyclin E1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccne1provided by RGD
Official Full Name: cyclin E1provided by RGD
Primary source: RGD:2294
See related: EnsemblRapid:ENSRNOG00000014786 AllianceGenome:RGD:2294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccne; CYCLE
Summary: Enables protein kinase binding activity. Involved in several processes, including response to corticosterone; response to progesterone; and response to vitamin E. Located in centrosome. Biomarker of hepatocellular carcinoma; hypertension; liver cancer; and ovarian carcinoma. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 120.2), Thymus (RPKM 85.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (99918672..99927986, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (90781947..90791188, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (94485830..94495112, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway.
Title: Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway.
Myc is critical in modulating the amplitude of cell cycle, whereas cyclin D/E activities have little effect on amplitude but do contribute to the modulation of duration of E2F1 activation, thereby affecting the pace of cell cycle progression.
Title: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.
Our data demonstrated that increased expression of ERK1/2 and cyclinE1 might be involved in the pathogenesis of abnormal rPASMCs proliferation and rat pulmonary vascular remodelling induced by cigarette smoke exposure.
Title: ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression.
These results support a novel role for neuronal cyclin E1 in regulating the phosphorylation status and localization of Kv2.1 channels, a likely component of signaling cascades leading to ischemic preconditioning.
Title: Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia.
Data indicate that proline-mediated mTOR activation and collagen synthesis were found critical for hepatocyte growth factor (HGF)-induced DNA synthesis, partly via the sufficient accumulation of cyclin-E1.
Title: Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes.
Overexpressed cyclin E/CDK2 molecules were stably associated with p107 and p130 in FGF-treated cells in the context of E2F repressive complexes.
Title: Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins.
these results support the involvement of cyclin E1.CDK2 in centrosome overduplication during each stage of E(2)-induced mammary tumorigenesis.
Title: Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen.
Cyclin E appears to be involved in the N-POMC- and adrenocorticotropic hormone-stimulated proliferation in the zona glomerulosa of the adrenal cortex.
Title: The proliferative effect of synthetic N-POMC(1-28) peptides in rat adrenal cortex: a possible role for cyclin E.
Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.
Title: Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.
analysis of expression of Cyclin D1, E, A and B1 in neurons of cerebral cortex and hippocampus
Title: The expression of cyclins in neurons of rats after focal cerebral ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94399 (e-PCR)
- UniSTS:119647

D1Bda17 (e-PCR)
- UniSTS:239764

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in antral ovarian follicle growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mesenchymal stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to purine-containing compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin E1-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E1-CDK2 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin E1-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G1/S-specific cyclin-E1

Names: cyclin E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100821.1 → NP_001094291.1 G1/S-specific cyclin-E1

See identical proteins and their annotated locations for NP_001094291.1

Status: VALIDATED

Source sequence(s)

BU760054, CK842479, DY561075, EV771022

UniProtKB/Swiss-Prot

O09138, P39949

UniProtKB/TrEMBL

B1WC54

Conserved Domains (2) summary

cd20581
Location:244 → 357

CYCLIN_CCNE1_rpt2; second cyclin box found in G1/S-specific cyclin-E1 (CCNE1)

cl40454
Location:104 → 240

CYCLIN_SF; Cyclin box fold superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

99918672..99927986 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228904.5 → XP_006228966.1 G1/S-specific cyclin-E1 isoform X1

See identical proteins and their annotated locations for XP_006228966.1

UniProtKB/Swiss-Prot

O09138, P39949

UniProtKB/TrEMBL

B1WC54

Related

ENSRNOP00000020014.4, ENSRNOT00000020014.6

Conserved Domains (2) summary

cd20581
Location:244 → 357

CYCLIN_CCNE1_rpt2; second cyclin box found in G1/S-specific cyclin-E1 (CCNE1)

cl40454
Location:104 → 240

CYCLIN_SF; Cyclin box fold superfamily