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    Ccdc66 coiled-coil domain containing 66 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306238, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccdc66provided by RGD
    Official Full Name
    coiled-coil domain containing 66provided by RGD
    Primary source
    RGD:1560873
    See related
    EnsemblRapid:ENSRNOG00000028380 AllianceGenome:RGD:1560873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560873
    Summary
    Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be involved in several processes, including detection of light stimulus involved in visual perception; regulation of protein localization to cilium; and retina homeostasis. Predicted to be located in several cellular components, including Flemming body; cytosol; and microtubule organizing center. Predicted to be active in cilium; microtubule; and photoreceptor inner segment. Orthologous to human CCDC66 (coiled-coil domain containing 66). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 112.8), Lung (RPKM 109.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccdc66 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2668810..2700717, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2662125..2694031, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3107119..3139188, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC102548056 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC134482440 Neighboring gene transcription activation suppressor Neighboring gene ATP synthase c subunit lysine N-methyltransferase, pseudogene 1 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding  
    enables microtubule binding  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in detection of light stimulus involved in visual perception  
    involved_in microtubule bundle formation  
    involved_in regulation of protein localization to cilium  
    involved_in retina homeostasis  
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in Flemming body  
    located_in cell junction  
    located_in cell junction  
    located_in centriolar satellite  
    located_in centrosome  
    located_in ciliary basal body  
    NOT located_in ciliary transition zone  
    is_active_in cilium  
    located_in cilium  
    located_in cytosol  
    located_in cytosol  
    is_active_in microtubule  
    located_in microtubule  
    is_active_in photoreceptor inner segment  
    located_in photoreceptor inner segment  

    General protein information

    Preferred Names
    coiled-coil domain containing 66; coiled-coil domain-containing protein 66

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432921.1NP_001419850.1  coiled-coil domain containing 66 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35, D3ZB56
    2. NM_001432922.1NP_001419851.1  coiled-coil domain containing 66 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35, A6KML1
    3. NM_001432923.1NP_001419852.1  coiled-coil domain containing 66 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35
    4. NM_001432924.1NP_001419853.1  coiled-coil domain containing 66 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35
    5. NM_001432925.1NP_001419854.1  coiled-coil domain containing 66 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35
    6. NM_001432926.1NP_001419855.1  coiled-coil domain containing 66 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35
    7. NM_001432927.1NP_001419856.1  coiled-coil domain containing 66 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AK35

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      2668810..2700717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095208.2XP_038951136.1  coiled-coil domain-containing protein 66 isoform X7

      Related
      ENSRNOP00000109132.1, ENSRNOT00000130259.1
      Conserved Domains (2) summary
      PTZ00121
      Location:218507
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:368519
      CCDC66; Coiled-coil domain-containing protein 66
    2. XM_039095211.2XP_038951139.1  coiled-coil domain-containing protein 66 isoform X13

      Conserved Domains (1) summary
      pfam15236
      Location:278429
      CCDC66; Coiled-coil domain-containing protein 66
    3. XM_039095210.2XP_038951138.1  coiled-coil domain-containing protein 66 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (1) summary
      pfam15236
      Location:308459
      CCDC66; Coiled-coil domain-containing protein 66
    4. XM_039095209.2XP_038951137.1  coiled-coil domain-containing protein 66 isoform X11

      Related
      ENSRNOP00000100432.1, ENSRNOT00000171348.1
      Conserved Domains (1) summary
      pfam15236
      Location:322473
      CCDC66; Coiled-coil domain-containing protein 66
    5. XM_063275913.1XP_063131983.1  coiled-coil domain-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AK35
    6. XM_063275912.1XP_063131982.1  coiled-coil domain-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AK35
      Related
      ENSRNOP00000036334.8, ENSRNOT00000039311.9
    7. XM_063275910.1XP_063131980.1  coiled-coil domain-containing protein 66 isoform X5

    8. XM_063275911.1XP_063131981.1  coiled-coil domain-containing protein 66 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AK35
    9. XM_039095199.2XP_038951127.1  coiled-coil domain-containing protein 66 isoform X3

      Conserved Domains (2) summary
      PTZ00121
      Location:218551
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:412563
      CCDC66; Coiled-coil domain-containing protein 66
    10. XM_039095198.2XP_038951126.1  coiled-coil domain-containing protein 66 isoform X2

      Conserved Domains (2) summary
      PTZ00121
      Location:218537
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:398549
      CCDC66; Coiled-coil domain-containing protein 66
    11. XM_039095197.1XP_038951125.1  coiled-coil domain-containing protein 66 isoform X1

      Related
      ENSRNOP00000106615.1, ENSRNOT00000147552.1
      Conserved Domains (2) summary
      PTZ00121
      Location:218551
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:412563
      CCDC66; Coiled-coil domain-containing protein 66
    12. XM_039095205.2XP_038951133.1  coiled-coil domain-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (2) summary
      PTZ00121
      Location:184517
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:378529
      CCDC66; Coiled-coil domain-containing protein 66
    13. XM_039095202.2XP_038951130.1  coiled-coil domain-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (2) summary
      PTZ00121
      Location:184517
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:378529
      CCDC66; Coiled-coil domain-containing protein 66
    14. XM_039095201.2XP_038951129.1  coiled-coil domain-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (2) summary
      PTZ00121
      Location:184517
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:378529
      CCDC66; Coiled-coil domain-containing protein 66
    15. XM_039095204.2XP_038951132.1  coiled-coil domain-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (2) summary
      PTZ00121
      Location:184517
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:378529
      CCDC66; Coiled-coil domain-containing protein 66
    16. XM_039095207.2XP_038951135.1  coiled-coil domain-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK35
      Conserved Domains (2) summary
      PTZ00121
      Location:184517
      PTZ00121; MAEBL; Provisional
      pfam15236
      Location:378529
      CCDC66; Coiled-coil domain-containing protein 66
    17. XM_063275914.1XP_063131984.1  coiled-coil domain-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AK35
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