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    Nsmce4a NSE4 homolog A, SMC5-SMC6 complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsmce4aprovided by RGD
    Official Full Name
    NSE4 homolog A, SMC5-SMC6 complex componentprovided by RGD
    Primary source
    RGD:1309025
    See related
    AllianceGenome:RGD:1309025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309025
    Summary
    Predicted to be involved in DNA damage response. Predicted to be located in nuclear body. Predicted to be part of Smc5-Smc6 complex. Orthologous to human NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 296.9), Spleen (RPKM 230.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsmce4a in Genome Data Viewer
    Location:
    1q37
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194532364..194539456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185102075..185109166, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201103750..201110838, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene arginyltransferase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene similar to RIKEN cDNA 1700022C21 Neighboring gene uncharacterized LOC134483930 Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene transfer RNA proline (anticodon AGG) 25 Neighboring gene uncharacterized LOC103691241

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-structural maintenance of chromosomes element 4 homolog A
    Names
    NSE4 homolog, SMC5-SMC6 complex component A
    non-SMC element 4 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106301.1 → NP_001099771.1  non-structural maintenance of chromosomes element 4 homolog A

      See identical proteins and their annotated locations for NP_001099771.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6IA36
      Conserved Domains (1) summary
      pfam15412
      Location:130 → 182
      Nse4-Nse3_bdg; Binding domain of Nse4/EID3 to Nse3-MAGE

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      194532364..194539456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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