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    Abtb1 ankyrin repeat and BTB domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abtb1provided by RGD
    Official Full Name
    ankyrin repeat and BTB domain containing 1provided by RGD
    Primary source
    RGD:1359363
    See related
    EnsemblRapid:ENSRNOG00000015762 AllianceGenome:RGD:1359363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ABTB1 (ankyrin repeat and BTB domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 156.4), Muscle (RPKM 107.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abtb1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122856558..122862895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121299302..121305667, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120778580..120784807, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486810 Neighboring gene monoglyceride lipase Neighboring gene transfer RNA valine (anticodon AAC) 19 Neighboring gene podocalyxin-like 2 Neighboring gene minichromosome maintenance complex component 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Unoki M, et al. Oncogene, 2001 Jul 27. PMID 11494141
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94157

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and BTB/POZ domain-containing protein 1
    Names
    ankyrin repeat and BTB (POZ) domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005902.1 → NP_001005902.1  ankyrin repeat and BTB/POZ domain-containing protein 1

      See identical proteins and their annotated locations for NP_001005902.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083579
      UniProtKB/Swiss-Prot
      Q5XIU1
      UniProtKB/TrEMBL
      A0A8I6AFV2, A6IB50
      Related
      ENSRNOP00000087062.1, ENSRNOT00000119739.2
      Conserved Domains (5) summary
      sd00045
      Location:35 → 60
      ANK; ANK repeat [structural motif]
      cd18295
      Location:97 → 214
      BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
      cd18296
      Location:254 → 377
      BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
      cd18497
      Location:376 → 447
      BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
      pfam12796
      Location:6 → 65
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      122856558..122862895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107368.2 → XP_038963296.1  ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFV2, A0A8L2QB88
      Related
      ENSRNOP00000021445.5, ENSRNOT00000021445.7
      Conserved Domains (3) summary
      cd18295
      Location:76 → 193
      BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
      cd18296
      Location:233 → 356
      BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
      cd18497
      Location:355 → 426
      BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

    2. XM_063285817.1 → XP_063141887.1  ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIU1.1 GenPept UniProtKB/Swiss-Prot:Q5XIU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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