Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Herc6provided by RGD
Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 6provided by RGD
Primary source: RGD:1561739
See related: EnsemblRapid:ENSRNOG00000023969 AllianceGenome:RGD:1561739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 160.1), Spleen (RPKM 121.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (88854612..88897043, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (87524470..87566895, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (88606851..88649424, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D4Got76 (e-PCR)
- UniSTS:114756

d4rat230 (e-PCR)
- UniSTS:121996

RH140011 (e-PCR)
- UniSTS:222093

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase HERC6

Names: hect domain and RLD 6; potential ubiquitin ligase

NP_001012492.1

EC 2.3.2.26

XP_038964615.1

EC 2.3.2.26

XP_038964617.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012474.1 → NP_001012492.1 probable E3 ubiquitin-protein ligase HERC6

Status: VALIDATED

Source sequence(s)

BC085921, JAXUCZ010000004

UniProtKB/TrEMBL

Q5U2P8

Related

ENSRNOP00000055422.6, ENSRNOT00000058626.6

Conserved Domains (2) summary

COG5184
Location:20 → 356

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd00078
Location:682 → 1023

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

88854612..88897043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108687.2 → XP_038964615.1 probable E3 ubiquitin-protein ligase HERC6 isoform X1

Conserved Domains (1) summary

cd00078
Location:314 → 655

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_039108689.2 → XP_038964617.1 probable E3 ubiquitin-protein ligase HERC6 isoform X2

Conserved Domains (1) summary

cd00078
Location:197 → 538

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...