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    Apln apelin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58812, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aplnprovided by RGD
    Official Full Name
    apelinprovided by RGD
    Primary source
    RGD:620672
    See related
    EnsemblRapid:ENSRNOG00000003984 AllianceGenome:RGD:620672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apel
    Summary
    Enables apelin receptor binding activity and identical protein binding activity. Involved in several processes, including apelin receptor signaling pathway; positive regulation of peptide hormone secretion; and regulation of blood circulation. Located in extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 268.4), Heart (RPKM 80.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Apln in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132058739..132091518, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127180801..127213567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (134856719..134866210, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 1, pseudogene 7 Neighboring gene OCRL, inositol polyphosphate-5-phosphatase Neighboring gene uncharacterized LOC134484146 Neighboring gene X-prolyl aminopeptidase 2 Neighboring gene SAM and SH3 domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables apelin receptor binding PubMed 
    enables apelin receptor binding  
    enables hormone activity  
    enables hormone activity  
    enables identical protein binding PubMed 
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in apelin receptor signaling pathway PubMed 
    involved_in apelin receptor signaling pathway  
    involved_in apelin receptor signaling pathway  
    involved_in coronary vasculature development  
    involved_in coronary vasculature development  
    involved_in drinking behavior PubMed 
    involved_in feeding behavior PubMed 
    involved_in gastrulation  
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of systemic arterial blood pressure PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in negative regulation of vasoconstriction PubMed 
    involved_in positive regulation of G protein-coupled receptor internalization PubMed 
    involved_in positive regulation of G protein-coupled receptor internalization  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of corticotropin secretion PubMed 
    involved_in positive regulation of corticotropin-releasing hormone secretion PubMed 
    involved_in positive regulation of heart contraction PubMed 
    involved_in positive regulation of heart rate PubMed 
    involved_in positive regulation of heat generation PubMed 
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of phosphorylation PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation  
    involved_in regulation of body fluid levels PubMed 
    involved_in regulation of the force of heart contraction PubMed 
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    apelin
    Names
    APJ endogenous ligand
    apelin, AGTRL1 ligand

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031612.3NP_113800.1  apelin preproprotein

      See identical proteins and their annotated locations for NP_113800.1

      Status: VALIDATED

      Source sequence(s)
      BC080843, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9R0R3
      Related
      ENSRNOP00000100018.1, ENSRNOT00000005331.7
      Conserved Domains (1) summary
      pfam15360
      Location:2377
      Apelin; APJ endogenous ligand

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132058739..132091518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100000.2XP_038955928.1  apelin isoform X1

      UniProtKB/Swiss-Prot
      Q9R0R3
      Conserved Domains (1) summary
      pfam15360
      Location:2377
      Apelin; APJ endogenous ligand
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