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    Efcab3 EF-hand calcium binding domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303589, updated on 9-Dec-2024

    Summary

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    Symbol
    Efcab3provided by RGD
    Full Name
    EF-hand calcium binding domain 3provided by RGD
    Primary source
    RGD:1305423
    See related
    EnsemblRapid:ENSRNOG00000042255 AllianceGenome:RGD:1305423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305423
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human EFCAB3 (EF-hand calcium binding domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 169.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Efcab3 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    190
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (90084495..90577145)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89583526..90077260)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93304559..93332849)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase pi 1, pseudogene 2 Neighboring gene uncharacterized LOC134480888 Neighboring gene integrin subunit beta 3 Neighboring gene uncharacterized LOC108352141 Neighboring gene U6 spliceosomal RNA Neighboring gene methyltransferase like 2 Neighboring gene cactin, spliceosome C complex subunit, pseudogene 2 Neighboring gene tousled-like kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC156757

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013972.3 → NP_001013994.1  EF-hand calcium-binding domain-containing protein 3

      See identical proteins and their annotated locations for NP_001013994.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A0JPN9, Q66HC0
      UniProtKB/TrEMBL
      A6HJX2, F1LN12
      Related
      ENSRNOP00000008019.6, ENSRNOT00000008019.8
      Conserved Domains (2) summary
      pfam13499
      Location:51 → 108
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:62 → 113
      EF-hand_8; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      90084495..90577145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086129.2 → XP_038942057.1  EF-hand calcium-binding domain-containing protein 3 isoform X7

      Conserved Domains (2) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_039086123.2 → XP_038942051.1  EF-hand calcium-binding domain-containing protein 3 isoform X1

      Related
      ENSRNOP00000104824.1, ENSRNOT00000150247.1
      Conserved Domains (3) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:6556 → 6606
      EF-hand_8; EF-hand domain pair

    3. XM_039086125.2 → XP_038942053.1  EF-hand calcium-binding domain-containing protein 3 isoform X3

      Conserved Domains (3) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:6538 → 6588
      EF-hand_8; EF-hand domain pair

    4. XM_039086126.2 → XP_038942054.1  EF-hand calcium-binding domain-containing protein 3 isoform X4

      Conserved Domains (3) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:6538 → 6588
      EF-hand_8; EF-hand domain pair

    5. XM_039086127.2 → XP_038942055.1  EF-hand calcium-binding domain-containing protein 3 isoform X5

      Conserved Domains (5) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd15897
      Location:4649 → 4673
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:4621 → 4743
      EFh_PEF; The penta-EF hand (PEF) family
      pfam13833
      Location:6521 → 6571
      EF-hand_8; EF-hand domain pair

    6. XM_039086128.2 → XP_038942056.1  EF-hand calcium-binding domain-containing protein 3 isoform X6

      Conserved Domains (3) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:6503 → 6553
      EF-hand_8; EF-hand domain pair

    7. XM_039086124.2 → XP_038942052.1  EF-hand calcium-binding domain-containing protein 3 isoform X2

      Conserved Domains (3) summary
      PTZ00184
      Location:155 → 286
      PTZ00184; calmodulin; Provisional
      COG5126
      Location:2598 → 2727
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:6555 → 6605
      EF-hand_8; EF-hand domain pair

    8. XM_039086130.2 → XP_038942058.1  EF-hand calcium-binding domain-containing protein 3 isoform X8

      Conserved Domains (2) summary
      COG5126
      Location:604 → 733
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:4562 → 4612
      EF-hand_8; EF-hand domain pair

    9. XM_039086131.1 → XP_038942059.1  EF-hand calcium-binding domain-containing protein 3 isoform X9

      Conserved Domains (2) summary
      COG5126
      Location:1653 → 1752
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:3638 → 3688
      EF-hand_8; EF-hand domain pair

    10. XM_039086132.1 → XP_038942060.1  EF-hand calcium-binding domain-containing protein 3 isoform X10

      Conserved Domains (2) summary
      COG5126
      Location:1486 → 1585
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam13833
      Location:3471 → 3521
      EF-hand_8; EF-hand domain pair

    11. XM_063269182.1 → XP_063125252.1  EF-hand calcium-binding domain-containing protein 3 isoform X11

    12. XM_063269183.1 → XP_063125253.1  EF-hand calcium-binding domain-containing protein 3 isoform X12

      UniProtKB/Swiss-Prot
      A0JPN9, Q66HC0
      UniProtKB/TrEMBL
      A6HJX2, F1LN12
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HC0.1 GenPept UniProtKB/Swiss-Prot:Q66HC0

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