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    Dmp1 dentin matrix acidic phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25312, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dmp1provided by RGD
    Official Full Name
    dentin matrix acidic phosphoprotein 1provided by RGD
    Primary source
    RGD:2508
    See related
    EnsemblRapid:ENSRNOG00000002167 AllianceGenome:RGD:2508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AG1; DMP-1; DENTMAT
    Summary
    Enables Hsp70 protein binding activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within positive regulation of cell-substrate adhesion and regulation of enamel mineralization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular matrix. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 12.5), Heart (RPKM 8.3) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Dmp1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5833111..5867154, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5528441..5542078, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6889851..6923961, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene integrin-binding sialoprotein Neighboring gene uncharacterized LOC120096547 Neighboring gene uncharacterized LOC108352697 Neighboring gene dentin sialophosphoprotein Neighboring gene SPARC like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding PubMed 
    enables extracellular matrix binding  
    enables extracellular matrix binding  
    enables extracellular matrix binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in extracellular matrix  
    located_in extracellular matrix  
    located_in extracellular matrix  
    located_in extracellular region  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    dentin matrix acidic phosphoprotein 1
    Names
    dentin matrix protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433761.1NP_001420690.1  dentin matrix acidic phosphoprotein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P98193
      UniProtKB/TrEMBL
      A0A8I6GLL4, A6K5S9
    2. NM_203493.5NP_987089.2  dentin matrix acidic phosphoprotein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_987089.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P98193
      UniProtKB/TrEMBL
      A2VD06
      Related
      ENSRNOP00000095386.2, ENSRNOT00000116244.2
      Conserved Domains (1) summary
      pfam07263
      Location:1489
      DMP1; Dentin matrix protein 1 (DMP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      5833111..5867154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272869.1XP_063128939.1  dentin matrix acidic phosphoprotein 1 isoform X1

    2. XM_006250622.5XP_006250684.1  dentin matrix acidic phosphoprotein 1 isoform X1

      Related
      ENSRNOP00000098948.1, ENSRNOT00000146800.1
      Conserved Domains (2) summary
      PHA02664
      Location:112195
      PHA02664; hypothetical protein; Provisional
      pfam07263
      Location:1504
      DMP1; Dentin matrix protein 1 (DMP1)
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