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    Inpp5f inositol polyphosphate-5-phosphatase F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309008, updated on 9-Dec-2024

    Summary

    Symbol
    Inpp5fprovided by RGD
    Full Name
    inositol polyphosphate-5-phosphatase Fprovided by RGD
    Primary source
    RGD:1305777
    See related
    EnsemblRapid:ENSRNOG00000020388 AllianceGenome:RGD:1305777
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase activity and protein homodimerization activity. Involved in negative regulation of peptidyl-serine phosphorylation. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including clathrin-coated pit; neuronal cell body; and recycling endosome. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 170.7), Kidney (RPKM 149.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Inpp5f in Genome Data Viewer
    Location:
    1q37
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192620891..192700681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183190480..183270276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (200037749..200116524)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483924 Neighboring gene BAG cochaperone 3 Neighboring gene minichromosome maintenance complex binding protein Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene SEC23 interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adult locomotory behavior  
    involved_in biological_process  
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress  
    involved_in clathrin-dependent endocytosis  
    involved_in negative regulation of axon regeneration  
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of peptidyl-serine phosphorylation PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within phosphatidylinositol catabolic process  
    involved_in phosphatidylinositol dephosphorylation  
    involved_in phosphatidylinositol dephosphorylation  
    involved_in positive regulation of receptor recycling  
    involved_in regulation of cell motility  
    involved_in regulation of endocytic recycling  
    involved_in regulation of endocytic recycling  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    Component Evidence Code Pubs
    located_in axon  
    is_active_in clathrin-coated endocytic vesicle  
    located_in clathrin-coated endocytic vesicle  
    located_in clathrin-coated pit  
    located_in cytoplasm  
    located_in dendrite  
    is_active_in early endosome  
    located_in early endosome  
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body  
    located_in recycling endosome  

    General protein information

    Preferred Names
    phosphatidylinositide phosphatase SAC2
    Names
    phosphatidylinositide phosphatase SAC2-like
    NP_001101024.2
    XP_008758104.1
    XP_038934395.1
    XP_038934420.1
    XP_063119483.1
    XP_063119485.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107554.1NP_001101024.2  phosphatidylinositide phosphatase SAC2

      See identical proteins and their annotated locations for NP_001101024.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6A7M9, A6IA11, D3ZKG7
      Related
      ENSRNOP00000027630.6, ENSRNOT00000027630.7
      Conserved Domains (2) summary
      pfam02383
      Location:50414
      Syja_N; SacI homology domain
      pfam12456
      Location:594695
      hSac2; Inositol phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192620891..192700681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078467.2XP_038934395.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7M9
      Related
      ENSRNOP00000088322.2, ENSRNOT00000099799.2
      Conserved Domains (2) summary
      COG5329
      Location:50566
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam12456
      Location:595671
      hSac2; Inositol phosphatase
    2. XM_063263413.1XP_063119483.1  phosphatidylinositide phosphatase SAC2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7M9, A0A8I6AE13
      Related
      ENSRNOP00000090690.1, ENSRNOT00000118340.2
    3. XM_008759882.4XP_008758104.1  phosphatidylinositide phosphatase SAC2 isoform X3

      Conserved Domains (2) summary
      pfam02383
      Location:50414
      Syja_N; SacI homology domain
      pfam12456
      Location:594628
      hSac2; Inositol phosphatase
    4. XM_063263415.1XP_063119485.1  phosphatidylinositide phosphatase SAC2 isoform X5

    5. XM_039078492.2XP_038934420.1  phosphatidylinositide phosphatase SAC2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVI2, A6IA14
      Related
      ENSRNOP00000082760.1, ENSRNOT00000106183.2
      Conserved Domains (1) summary
      pfam12456
      Location:373
      hSac2; Inositol phosphatase
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