Pycr3 pyrroline-5-carboxylate reductase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pycr3provided by RGD
Official Full Name: pyrroline-5-carboxylate reductase 3provided by RGD
Primary source: RGD:1309115
See related: AllianceGenome:RGD:1309115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pycrl
Summary: Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be part of eukaryotic translation elongation factor 1 complex. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 121.2), Kidney (RPKM 103.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109484263..109489554, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107603543..107608831, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116949882..116955150, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134115 (e-PCR)
- UniSTS:217397

AI169002 (e-PCR)
- UniSTS:250167

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pyrroline-5-carboxylate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrroline-5-carboxylate reductase activity	IEA Inferred from Electronic Annotation more info
enables pyrroline-5-carboxylate reductase activity	ISO Inferred from Sequence Orthology more info
enables pyrroline-5-carboxylate reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-proline biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-proline biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation elongation factor 1 complex	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyrroline-5-carboxylate reductase 3

Names: P5C reductase 3; P5CR 3; pyrroline-5-carboxylate reductase-like protein

NP_001011993.1

EC 1.5.1.2

XP_038934748.1

EC 1.5.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011993.1 → NP_001011993.1 pyrroline-5-carboxylate reductase 3

See identical proteins and their annotated locations for NP_001011993.1

Status: PROVISIONAL

Source sequence(s)

BC087166

UniProtKB/Swiss-Prot

Q5PQJ6

UniProtKB/TrEMBL

A6HS37

Conserved Domains (3) summary

PLN02688
Location:10 → 273

PLN02688; pyrroline-5-carboxylate reductase

pfam03807
Location:12 → 104

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

pfam14748
Location:166 → 270

P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109484263..109489554 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078820.2 → XP_038934748.1 pyrroline-5-carboxylate reductase 3 isoform X1

UniProtKB/TrEMBL

A0A8L2UQA6

Conserved Domains (1) summary

PLN02688
Location:10 → 288

PLN02688; pyrroline-5-carboxylate reductase