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    Gpr174 G protein-coupled receptor 174 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr174provided by RGD
    Official Full Name
    G protein-coupled receptor 174provided by RGD
    Primary source
    RGD:1564689
    See related
    EnsemblRapid:ENSRNOG00000032970 AllianceGenome:RGD:1564689
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564689
    Summary
    Predicted to enable bioactive lipid receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of interleukin-2 production. Predicted to act upstream of or within T cell homeostasis. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Orthologous to human GPR174 (G protein-coupled receptor 174). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 166.1), Thymus (RPKM 131.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr174 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (76428274..76469020)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (72355452..72396146)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (78358347..78399944)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene P2Y receptor family member 10B Neighboring gene prohibitin 1, pseudogene 3 Neighboring gene enolase 1, pseudogene 29 Neighboring gene integral membrane protein 2A Neighboring gene prohibitin 1, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. Barnes MJ, et al. J Exp Med, 2015 Jun 29. PMID 26077720, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bioactive lipid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 174

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106938.1 → NP_001100408.1  probable G-protein coupled receptor 174

      See identical proteins and their annotated locations for NP_001100408.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473969
      UniProtKB/TrEMBL
      A6IV67, D3ZWS1
      Related
      ENSRNOP00000111173.1, ENSRNOT00000147393.1
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      76428274..76469020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257163.5 → XP_006257225.1  probable G-protein coupled receptor 174 isoform X1

      See identical proteins and their annotated locations for XP_006257225.1

      UniProtKB/TrEMBL
      A6IV67, D3ZWS1
      Related
      ENSRNOP00000044021.3, ENSRNOT00000046164.5
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006257164.5 → XP_006257226.1  probable G-protein coupled receptor 174 isoform X1

      See identical proteins and their annotated locations for XP_006257226.1

      UniProtKB/TrEMBL
      A6IV67, D3ZWS1
      Related
      ENSRNOP00000107694.1, ENSRNOT00000169039.1
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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