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    Ttc7a tetratricopeptide repeat domain 7A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362696, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttc7aprovided by RGD
    Official Full Name
    tetratricopeptide repeat domain 7Aprovided by RGD
    Primary source
    RGD:1306211
    See related
    EnsemblRapid:ENSRNOG00000014879 AllianceGenome:RGD:1306211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ttc7
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to act upstream of or within hemopoiesis and intracellular iron ion homeostasis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 86.4), Lung (RPKM 78.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ttc7a in Genome Data Viewer
    Location:
    6q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12912822..13015374, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7159285..7261826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10912383..11014279)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene calmodulin 2 Neighboring gene sperm-tail PG-rich repeat containing 4 Neighboring gene microRNA 3558 Neighboring gene uncharacterized LOC120103465 Neighboring gene uncharacterized LOC134479306 Neighboring gene multiple coagulation factor deficiency 2, ER cargo receptor complex subunit Neighboring gene uncharacterized LOC134479307

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 7A
    Names
    tetratricopeptide repeat domain 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100756.1NP_001094226.1  tetratricopeptide repeat protein 7A

      See identical proteins and their annotated locations for NP_001094226.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168226
      UniProtKB/TrEMBL
      A0A8I5ZS78, B4F7D1
      Related
      ENSRNOP00000058460.4, ENSRNOT00000061747.5
      Conserved Domains (2) summary
      sd00006
      Location:747773
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:712776
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      12912822..13015374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262049.1XP_063118119.1  tetratricopeptide repeat protein 7A isoform X1

    2. XM_039112459.2XP_038968387.1  tetratricopeptide repeat protein 7A isoform X3

      Conserved Domains (2) summary
      TIGR00990
      Location:153498
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:402428
      TPR; TPR repeat [structural motif]
    3. XM_008764464.4XP_008762686.1  tetratricopeptide repeat protein 7A isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:412438
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:377441
      TPR_11; TPR repeat
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